State of free-radical processes and antioxidant defence of patients with psoriasis and concomitant essential hypertension

Visir, V. A.; Макурина, Г. И.

doi:10.14739/2310-1210.2016.4.79730

Cited by 7 publications

(2 citation statements)

References 19 publications

(20 reference statements)

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“…The markers of oxidative modification of proteins (aldehydephenylhydrazones (APH) and ketonephenylhydrazones (KPH)) were evaluated spectrophotometrically by the method of B. Halliwell at 270 nm and 363 nm [11]. The content of carbonyl derivatives of oxidized proteins was expressed in units of optical density per mg of protein.…”

Section: Methodsmentioning

confidence: 99%

The Impact of Metformin and Rosuvastatin on the Markers of Oxidative Stress, Glycemic Control, and Lipid Profile in Rats With Streptozotocin-Nicotinamide-Induced Diabetes After Acute Intracerebral Hemorrhage

Zhyliuk

Lievykh

Шевцова

et al. 2021

PEP

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Hyperproduction of highly active carbonyl compounds and reactive oxygen species initiates the development of oxidative stress in various pathological conditions and protein carbonylation is considered to be one of the key factors in the progression of diabetes mellitus and associated complications. This comparative research aimed to study the effect of metformin and rosuvastatin on the levels of biochemical markers of oxidative stress, glycemic control, and lipid profile in rats with type 2 diabetes mellitus (T2DM) complicated by a brain hemorrhage.T2DM was simulated with a single intraperitoneal injection of nicotinamide and streptozotocin (NA/STZ) to male Wistar rats (n=38). Intracerebral hemorrhage (ICH) was induced by microinjection of 1 μL of bacterial collagenase 0.2 IU/μL into the striatum. Animals were randomized into 5 groups: negative control, intact rats; positive control 1, NA/STZ; positive control 2, NA/STZ+ICH; metformin, 250 mg/kg +NA/STZ+ICH; rosuvastatin, 15 mg/kg+NA/STZ+ICH. Drug effects were assessed by the area under the glycemic curve (AUC), the content of glucose, glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), homocysteine (Hcy), advanced glycation end products (AGEs), and the markers of oxidative modification of proteins – aldehyde- and ketonephenylhydrazones (APH/KPH) in blood serum.It was found that brain hemorrhage in rats with T2DM can intensify the manifestations of oxidative modification of molecules and worsen glycemic control and lipid profile. Under these conditions, rosuvastatin improved lipid metabolism and reduced the levels of AGEs by 35.1% but did not affect glycemia and content of APH/KPH. Metformin reduced oxidative stress (AGEs by 35.4%, KPH by 21.2%) as well as improved both glycemic status and lipid profile (TG level by 20.2%, TG/HDL ratio by 31.9%). Both drugs did not produce any effect on Hcy level.Thus, metformin in conditions of T2DM complicated by acute ICH has advantages over rosuvastatin in relation to the markers of oxidative modification and glycemic control.

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Section: Methodsmentioning

confidence: 99%

The Impact of Metformin and Rosuvastatin on the Markers of Oxidative Stress, Glycemic Control, and Lipid Profile in Rats With Streptozotocin-Nicotinamide-Induced Diabetes After Acute Intracerebral Hemorrhage

Zhyliuk

Lievykh

Шевцова

et al. 2021

PEP

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“…The most important enzymes that reduce the concentration of oxidants in the body include superoxide dismutase (SOD) and catalase (CAT). SOD catalyzes the dissociation of superoxide anion radicals to hydrogen peroxide and oxygen, whereas CAT is responsible for the distribution of hydrogen peroxide toxic to the body to water and oxygen (Visir & Makurina, ). Their reduced activity in patients with psoriasis compared to healthy persons also leads to the conclusion of the participation of oxidative stress in the etiology of psoriasis (Houshang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of changes in expression pattern of oxidative stress genes under the influence of adalimumab

Grabarek

Wcisło‐Dziadecka

Sanakiewicz

et al. 2019

Dermatologic Therapy

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The psoriasis therapy consists of the inhibition of cytokines involved in inducing and development of this disease. The aim of the study was to evaluate the changes in the expression of genes related to the oxidative stress phenomenon in the culture of normal human dermal fibroblasts of Normal Human Dermal Fibroblasts (NHDF) exposed to adalimumab. NHDF culture was exposed to adalimumab for 2‐, 8‐, and 24‐hr periods. The control consisted of the same cells not exposed to adalimumab. The oligonucleotide microarrays HG‐U133A 2.0 were used to analyze the changes in gene expression in NHDF culture. Analysis showed that there are 3,881 ID mRNA involved in the induction and development of oxidative stress, the expression of which changes significantly due to the exposure of NHDF cells to adalimumab (p < .05) among 1,369 ID mRNA of them. These include genes associated with apoptosis, the p38 MAPK pathway and the PDGF pathway, and above all with pathways not yet classified. Studies have shown that two genes: NR4A2 and IL1RN, whose expression has changed the most, expressed as Fold Change (FC) seem to be the most promising molecular markers to monitor therapy and loss of cell sensitivity to treatment.

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The state of lipid exchange and thrombotic link of hemostasis in patients with chronic non-specific inflammatory diseases of genitals

et al. 2019

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It has been stated that changes of lipid exchange and increasing of lipid peroxidation are accompanied by the inflammatory process, which show the increase of proatherogenic blood characteristics. In patients with chronic non-specific inflammatory diseases of genitals disorders of phagocytosis mechanisms, increasing of autointoxication and reaction of hypersensitivity of immediate type are revealed after full blood count index. On the basis of analyses results one can conclude that the increase of atherogenic properties of blood plasma in patients with chronic non-specific inflammatory diseases of genitals took place in accordance with vascular endothelium damage. The article is the first to show the effectiveness of complex treatment of different atherosclerotic pathogenesis links by means of correction of proatherogenic lipid fractions and antioxidative complexes.

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State of free-radical processes and antioxidant defence of patients with psoriasis and concomitant essential hypertension

Cited by 7 publications

References 19 publications

The Impact of Metformin and Rosuvastatin on the Markers of Oxidative Stress, Glycemic Control, and Lipid Profile in Rats With Streptozotocin-Nicotinamide-Induced Diabetes After Acute Intracerebral Hemorrhage

The Impact of Metformin and Rosuvastatin on the Markers of Oxidative Stress, Glycemic Control, and Lipid Profile in Rats With Streptozotocin-Nicotinamide-Induced Diabetes After Acute Intracerebral Hemorrhage

Evaluation of changes in expression pattern of oxidative stress genes under the influence of adalimumab

The state of lipid exchange and thrombotic link of hemostasis in patients with chronic non-specific inflammatory diseases of genitals

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