Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Amioka, Naofumi; Miyoshi, Toru; Otsuka, Hiroaki; Yamada, Daisuke; Takaishi, Atsushi; Ueeda, Masayuki; Hirohata, Satoshi; Ito, Hiroshi

doi:10.1016/j.jjcc.2019.02.012

Cited by 9 publications

(8 citation statements)

References 26 publications

(32 reference statements)

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“…Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is similar to ox-LDL and represents one of the major products of lipid peroxidation [ 43 ]. Research conducted by Amioka and colleagues (2019) revealed the association of high MDA-LDL levels with AMI compared to those with unstable angina.…”

Section: Oxidant Biomarkers In the Diagnosis And Prognosis Of Cvdmentioning

confidence: 99%

Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression

et al. 2022

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Cardiovascular disease (CVD) remains the leading cause of death globally, with unhealthy lifestyles today greatly increasing the risk. Over the decades, scientific investigation has been carried out on reactive oxygen species (ROS) and their resultant oxidative stress based on their changes made on biological targets such as lipids, proteins, and DNA. Since the existing clinical studies with antioxidants failed to provide relevant findings on CVD prediction, the focus has shifted towards recognition of oxidised targets as biomarkers to predict prognosis and response to accurate treatment. The identification of redox markers could help clinicians in providing risk stratification for CVD events beyond the traditional prognostic and diagnostic targets. This review will focus on how oxidant-related parameters can be applied as biomarkers for CVD based on recent clinical evidence.

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Section: Oxidant Biomarkers In the Diagnosis And Prognosis Of Cvdmentioning

confidence: 99%

Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression

et al. 2022

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“…Acute myocardial infarction inevitably causes ischemic–anoxic myocardial injury, which induces intensive ROS production [ 55 ]. Since MDA levels correlate with AMI severity, this indicator has been used as a determinant of severe coronary diseases [ 56 ]. Moreover, it was also shown that lipid peroxidation levels measured in patients’ plasma positively correlated with the severity of dilated cardiomyopathy symptoms [ 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Acetylsalicylic Acid in the Myocardial Ischemia-Reperfusion Model on Oxidative Stress Markers Levels in Heart Muscle and Serum

et al. 2022

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Heart failure occurs in increased oxidative stress conditions, which contribute to the progression of pathological changes. Orally or intravenously administered acetylsalicylic acid (ASA, aspirin) is typically used in human patients with acute myocardial ischemia. The study used an experimental porcine ischemia-reperfusion model to evaluate the potential cardioprotective effect of intracoronary administered ASA on myocardial ischemia-reperfusion injury. The cardioprotective effect of ASA was evaluated by measuring selected oxidative stress markers levels in infarcted and non-infarcted myocardium 14 days after the procedure, and three times in serum, before the procedure, during the reperfusion process, and after 14-day recovery. The results showed that intracoronary administrated ASA reduced the oxidative stress. The level of oxidative stress, measured with the non-enzymatic markers total antioxidant capacity (TAC), total oxidative status (TOS), and malondialdehyde (MDA), and the enzymatic markers glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione S-transferase (GST), in heart tissue was significantly higher in a control group injected with saline. The level of oxidative stress in serum, measured with TAC, TOS, oxidative stress index (OSI), and lipofuscin (LF), was also higher in the control group than in animals injected with ASA. The confirmed cardioprotective effect of intracoronary administered ASA provides the foundation for further studies on ASA intracoronary application, which may lead to the development of a new therapy for the treatment of ischemia-reperfusion complications in humans.

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“…Higher MDA levels are related to ischemic damage or unstable plaque in ACS patients [27] . Moreover, MDA levels were correlated with the AMI rate, and MDA levels have been used as a determinant for severe coronary diseases [28] . Nand et al reported that MDA levels in an AMI group increased three-fold compared to those of healthy individuals [8] .…”

Section: Discussionmentioning

confidence: 99%

Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI)

Aladağ¹,

Asoğlu²,

Özdemir³

et al. 2021

J Med Biochemistry

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Background: Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase (SOD), and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI. Methods: The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography. Results: Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p<0.001). In addition, patients with STEMI had IMA levels that were significantly greater than those of the patients with NSTEMI (p <0.001), while the reverse was true for MDA levels (p<0.001). The healthy controls had the highest levels of SOD and catalase levels, followed by patients with STEMI and patients with NSTEMI, respectively (p <0.001). There was a significant negative correlation among MDA and SOD with catalase levels (r = -0.771 p <0.001 MDA vs catalase; r = -0.821 p <0.001 SOD vs catalase). Conclusions: Data obtained in this study reveals that compared to healthy controls, STEMI and NSTEMI patients had increased levels MDA and IMA, and decreased levels of SOD and catalase.

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Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Cited by 9 publications

References 26 publications

Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression

Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression

Cardioprotective Effect of Acetylsalicylic Acid in the Myocardial Ischemia-Reperfusion Model on Oxidative Stress Markers Levels in Heart Muscle and Serum

Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI)

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