Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression

Kong, Amanda Shen-Yee; Lai, Kok Song; Hee, Cheng-Wan; Loh, Jiun-Yan; Lim, Swee Hua Erin; Maran, Sathiya

doi:10.3390/antiox11061175

Cited by 15 publications

(10 citation statements)

References 78 publications

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“…We chose this subregion for further investigation into its potential association with baseline aortic diameter, mtDNA‐CN (surrogate marker of mitochondrial function), and plasma myeloperoxidase (oxidative stress marker). 39 , 40 Interestingly, we observed that the positive association between MT‐TAS2 mutation status, baseline aortic diameter, and the oxidative stress marker myeloperoxidase was present only in individuals with low mtDNA‐CN (Figure 2C and 2D and Table S6 ). This observation suggests that having a low mtDNA‐CN at baseline might exacerbate the impact of MT‐TAS2 conserved region mutation in AAA pathology.…”

Section: Discussionmentioning

confidence: 81%

Characterization of the Mitochondrial Genetic Landscape in Abdominal Aortic Aneurysm

Vats

Sundquist

et al. 2023

JAHA

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Background Abdominal aortic aneurysm (AAA) is a vascular disease with a mortality rate of >80% if ruptured. Mitochondrial dysfunction has been previously implicated in AAA pathogenesis. In this study, we aimed to characterize the mitochondrial genetic landscape in AAA. Methods and Results Whole mitochondrial genome sequencing and bioinformatics analysis were performed in comorbidity matched 48 cases without AAA and 48 cases with AAA, objectively diagnosed, and selected from a cohort of 65‐year‐old men recruited for a screening program. We identified differential mutational landscapes in men with and without AAA, with errors in mitochondrial DNA replication or repair as potential sources. Heteroplasmic insertions and overall heteroplasmy of structural rearrangements were significantly elevated in AAA cases. Three heteroplasmic variants were associated with risk factors of AAA: leukocyte concentration, plasma glucose, and cholesterol levels, respectively. Interestingly, mutations were more prevalent in regulatory part of the mitochondria, the displacement loop region, in AAA as compared with controls ( P value <0.05), especially in the conserved and critical mitochondrial extended termination‐associated sequence region. Moreover, we report a novel 24 bp mitochondrial DNA duplication present exclusively in cases with AAA (4%) and 75% of the unmatched AAA biopsies. Finally, the haplogroup cluster JTU was overrepresented in AAA and significantly associated with a positive family history of AAA (odds ratio, 2.9 [95% CI, 1.1–8.1]). Conclusions This is the first study investigating the mitochondrial genome in AAA, where important genetic alterations and haplogroups associated with AAA and clinical risk factors were identified. Our findings have the potential to fill in gaps in the missing genetic information on AAA.

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Section: Discussionmentioning

confidence: 81%

Characterization of the Mitochondrial Genetic Landscape in Abdominal Aortic Aneurysm

Vats

Sundquist

et al. 2023

JAHA

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“…The BN is a food matrix and, in addition to Se, also contains unsaturated fats, such as monounsaturated fatty acids (MUFAs), which have recognized functions in TC, TGs, and LDL-c in healthy subjects [ 47 , 48 ]. The benefits of the BN in reducing ox-LDLs, known oxidative stress marker and a risk factor for atherosclerosis [ 49 ], are easier to explain because Se is a non-enzymatic antioxidant and contributes to the selenoproteins’ formation, adding to the redox balance by scavenging free radicals [ 50 ]. Excessive concentrations of these free radicals in the body can oxidize LDL-c, stimulating inflammation and leading to endothelial dysfunction in the intimal artery.…”

Section: Resultsmentioning

confidence: 99%

Effects of Regular Brazil Nut (Bertholletia excelsa H.B.K.) Consumption on Health: A Systematic Review of Clinical Trials

Silva

Silveira

Freitas

et al. 2022

Foods

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The Brazil nut (BN) is a promising food due to its numerous health benefits, but it is still necessary to systematically review the scientific evidence on these benefits. Thus, we examined the effects of regular BN consumption on health markers in humans according to the health state (with specific diseases or not) of the subjects. PubMed, Embase®, and Scielo databases were used to search for clinical trials. The PRISMA guideline was used to report the review, and the risk of bias for all studies was assessed. Twenty-four studies were included in the present review, of which fifteen were non-randomized. BNs were consumed in the context of a habitual free-living diet in all studies. Improvement in antioxidant status through increased levels of selenium and/or glutathione peroxidase activity in plasma, serum, whole blood, and/or erythrocytes was observed in all studies that evaluated antioxidant status, regardless of the health state of the sample. In addition, healthy subjects improved lipid markers and fasting glucose. Subjects with obesity had improvement in markers of lipid metabolism. Subjects with type 2 diabetes mellitus or dyslipidemia improved oxidative stress or DNA damage. Subjects undergoing hemodialysis benefited greatly from BN consumption, as they improved lipid profile markers, oxidative stress, inflammation, and thyroid function. Older adults with mild cognitive impairment improved verbal fluency and constructional praxis, and controversial results regarding the change in a marker of lipid peroxidation were observed in subjects with coronary artery disease. In conclusion, the benefits of BN consumption were found in different pathways of action and study populations.

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“…The results in table (6) Data presented as mean ± SEM. The different superscript letters denoted to significant differences p<0.05, n=5, DISCUSSION In general, propolis and its nano-formulas reported to have anti-inflammatory and antioxidant properties that can be contribute to decrease toxicity of different drug materials (16). The limitation of the extract uses was related to large dosed amount, non-specified targeted effects, and inadequacy of efficacious effects.…”

Section: Serum Cardiac Lactate Dehydrogenase Levelmentioning

confidence: 96%

Propolis flavonoids liposome ameliorate doxorubicin-induced cardiotoxicity in rats

2023

JPTCP

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The clinical applications of doxorubicin (DOX), a potent anthracycline antineoplastic drug, is often restricted by its deleterious cardiotoxic effects. Thus, for improving usage of DOX, the aim of this study was to assess the cardio-protective effects of nanopropolis in a rat model of DOX-induced acute cardiotoxicity. Through maceration method for 7 days in ethanol then 7 days in absolute ethyl acetate, flavonoidal propolis extract was obtained. twenty albino Rats were divided in to four equal groups: Control rats that received BPS for 10 days, DOX-treated rats that recived a single I.P injection of DOX (25 mg/kg BW) on day 7 from beginning of experiment. Rats received liposome orally for 10 consecutive days and single dose of doxorubicin (25 mg/kg BW IP) on day 7 from beginning of experiment. Rats groups received propolis liposome formulas orally for 10 consecutive days and single dose of doxorubicin (25 mg/kg BW IP) on day 7 from beginning of experiment. Sera were collected for screening of cardiac injury markers.The administration of DOX in single dose showed high cardiac biomarkers CK-MB, Troponin I, and LDH than in the negative group.Treatment with propolis nanoformulas shown ameliorated the DOX-induced cardiac tissue damage by decline the serum levels of CK-MB, Troponin I, and Lactate dehydrogenase. The experiment parts endorsed conclusion that nanopropolis may exhibit remarkable protective effect in DOX-induced cardiac toxicity through improve a number of cardiac biomarkers linked with cardiac toxicity, and may be represent a potential agents for attenuation and prevention of the serious complications accompanied with DOX in clinical practice.

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Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression

Cited by 15 publications

References 78 publications

Characterization of the Mitochondrial Genetic Landscape in Abdominal Aortic Aneurysm

Characterization of the Mitochondrial Genetic Landscape in Abdominal Aortic Aneurysm

Effects of Regular Brazil Nut (Bertholletia excelsa H.B.K.) Consumption on Health: A Systematic Review of Clinical Trials

Propolis flavonoids liposome ameliorate doxorubicin-induced cardiotoxicity in rats

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