Serum levels of tumor necrosis factor-α, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis

Bayraktaroğlu, Taner; Aras, Ahmet Sükrü; Aydemır, Selim; Davutoğlu, Can; Üstündağ, Yücel; Atmaca, Hulusi; Borazan, Ali

doi:10.1080/09629350410001664789

Cited by 33 publications

(26 citation statements)

References 20 publications

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“…Although there was not a statistically significant relationship between gender and these cytokines, the average IL-1β and TNF-α were higher in males than in females. In a study on circulating serum levels of IL-6, IL-8 and TNF-α in patients with H. pylori infection, there was not a significant difference in serum levels of TNF-α and age and gender between positive and negative H. Pylori groups (23), which is consistent with the results of our study. The results of this study and the study by Fan showed that the pathogen makes no significant change in serum levels of TNF-α (23,24).…”

Section: Discussionsupporting

confidence: 83%

“…In a study on circulating serum levels of IL-6, IL-8 and TNF-α in patients with H. pylori infection, there was not a significant difference in serum levels of TNF-α and age and gender between positive and negative H. Pylori groups (23), which is consistent with the results of our study. The results of this study and the study by Fan showed that the pathogen makes no significant change in serum levels of TNF-α (23,24). However, data from our study showed an increase in serum levels of IL-1β and TNF-α cytokines in people infected with H. pylori, in another study, the average of these two cytokines was significantly higher in infected group with H. pylori than non-infected individuals (22,25).…”

Section: Discussionsupporting

confidence: 83%

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Correlation of 16s rRNA with serum levels of the cytokines, TNF-α and IL-1β, in subjects with a positive Helicobacter pylori Stool Antigen test (HPSA)

Moradipour

Khosravi

Mehrabi

et al. 2016

JBRMS

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Introduction:Helicobacter pylori (H. pylori), is a bacterium responsible for upper gastrointestinal tract diseases. The 16s rRNA is a common H. pylori gene which are usually preferred for diagnosis purpose. The aim of this study was to determine the prevalence and abundance of 16s rRNA in fecal samples and also evaluate correlation between the level of 16s rRNA and activities of the cytokines, TNF-α and IL-1β, in serum. Materials and methods:The present study was performed on 84 subjects with digestion problems. Fecal and blood samples were collected and 16s rRNA gene was assayed using PCR. The serum levels of TNF-α and IL-1β levels were measured by enzyme-linked immunosorbent assay (ELISA). Results:The results of the study revealed that there was a positive correlation between the 16s rRNA gene, H. pylori stool antigen (HPSA) and TNF-α cytokine. The study also noted that with every unit of increase in either of the quantified parameters of HPSA and IL-1β, the presence of 16s rRNA in fecal samples, showed a 2.98 and 1.01 times rise, respectively. Conclusion: According to the obtained results, it may be concluded that activities of cytokine TNF-a correlated well with the presence of HPSA and 16srRNA gene in the stomach's lining. Increase in the activities of HPSA and TNF-a cytokine could be associated with the presence of 16s rRNA in feces.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

Correlation of 16s rRNA with serum levels of the cytokines, TNF-α and IL-1β, in subjects with a positive Helicobacter pylori Stool Antigen test (HPSA)

Moradipour

Khosravi

Mehrabi

et al. 2016

JBRMS

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“…These results support the idea that past or chronic exposure to H. pylori infection, perhaps as a result of exacerbating inflammation, contributes to the onset of atherosclerosis. However, there are inconsistent data concerning markers of systematic inflammation in H. pylori-positive subjects [107][108][109] . This inconsistency can be attributed to differences in the studied ethnic groups, as different groups may develop inflammatory reactions via distinct mechanisms.…”

Section: H Pylori and Endothelial Dysfunctionmentioning

confidence: 99%

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Yang

Lü

2014

JAT

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Accumulating evidence implicates Helicobacter pylori (H. pylori) infection in the pathogenesis of certain diseases localized outside the stomach, particularly those characterized by persistent and lowgrade systematic inflammation. Recently, the role of H. pylori infection in the development of atherosclerosis and its clinical complications has received attention. Atherosclerosis is a high-cost disease, and acute events resulting from this condition rank first among morbidity and mortality statistics in most industrialized countries. Atherosclerosis is a multifactorial disorder, and traditional risk factors explain only 50% of its etiology. Therefore, identifying new risk factors for atherosclerosis is necessary. Serological studies indicate that chronic H. pylori infection, especially that with more virulent strains, may predispose patients to the onset of atherosclerosis and related adverse clinical events, and PCR studies have detected H. pylori DNA in atherosclerotic plaques, although this finding remains controversial. If this association were to be confirmed, its importance to public health would be substantial, as the eradication of H. pylori is more straightforward and less costly than the longterm treatment of other risk factors. This review investigates the potential relationship between H. pylori infection and atherosclerosis from both epidemiological and pathogenic perspectives and characterizes the potential mechanisms underlying this correlation.

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“…The stomach has a large surface area and a continuous spill-over of locally produced cytokines into the blood stream is a possibility. Several studies produced conflicting data about the synthesis and secretion of a variety of proinflammatory cytokines in patients with H. pylori infection (5,(28)(29).…”

mentioning

confidence: 99%

Serum and Mucosal Cytokine Profiles in Patients with Active Helicobacter Pylori and Ischemic Heart Disease: Is There a Relationship?

Bonaventura

Piccolomini

Pompilio

et al. 2007

Int J Immunopathol Pharmacol

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This study is designed to investigate, for the first time, circulating and gastric mucosal levels ofILl-a, IL-6, IL-8 and TNF-a in patients with ischemic heart disease (IUD) and matched controls, according to the presence or absence of active Helicobacter pylori infection. Furthermore, in order to evaluate whether modified lipid profile was associated to an increased cardiovascular risk, this was determined in the same groups. Cytokine levels were measured using ELISA in 58 patients with IUD and 52 controls. Active H. pylori infection was assessed if either culture of H. pylori or rapid urease test gave a positive result. Our findings indicate increasing cytokine mucosal levels in H. pylori-positive patients compared to H. pylorinegative subjects. However, the increase was statistically significant only for IL-6 and TNF-a in the gastric mucosa of IUD patients. In H. pylori-positive controls, IL-8 mucosal levels positively correlated with both IL-la (r = 0.98; P = 0.0003) and IL-6 (r = 0.83; P = 0.03) levels. Circulating cytokine levels were comparable in IUD and healthy subjects, regardless of H. pylori status. There were no correlations between mucosal and circulating cytokine levels. Active H. pylori infection was not associated with a modified lipid profile in either controls or IUD patients, although ApoAI levels were significantly higher in H. pylori-positive controls compared to those H. pylori-negative. Taken together, the results of the present study provide evidence that active H. pylori infection may playa role as a trigger factor in the pathophysiology of IUD by inducing an inflammatory cascade concentrated on gastric mucosa. Cardiovascular diseases constitute one of the leading causes for mortality and morbidity in industrialized countries (I). In particular, ischemic heart disease (IHD) is the single biggest contributor to cardiac mortality. Major factors associated with an increased risk of IHD are well known, but not all of IHD incidence can be attributed to serum lipids, hypertension, smoking, obesity and diabetes (2). It is, therefore, important to identify additional causes ofIHD.Atherosclerosis is now generally accepted as an inflammatory disorder in the arterial wall (3). Since the first evidence reported by Mendall et al. (4), a number of studies have confirmed the key

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Serum levels of tumor necrosis factor-α, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis

Cited by 33 publications

References 20 publications

Correlation of 16s rRNA with serum levels of the cytokines, TNF-α and IL-1β, in subjects with a positive Helicobacter pylori Stool Antigen test (HPSA)

Correlation of 16s rRNA with serum levels of the cytokines, TNF-α and IL-1β, in subjects with a positive Helicobacter pylori Stool Antigen test (HPSA)

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Serum and Mucosal Cytokine Profiles in Patients with Active Helicobacter Pylori and Ischemic Heart Disease: Is There a Relationship?

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