2007
DOI: 10.1177/039463200702000119
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Serum and Mucosal Cytokine Profiles in Patients with Active Helicobacter Pylori and Ischemic Heart Disease: Is There a Relationship?

Abstract: This study is designed to investigate, for the first time, circulating and gastric mucosal levels ofILl-a, IL-6, IL-8 and TNF-a in patients with ischemic heart disease (IUD) and matched controls, according to the presence or absence of active Helicobacter pylori infection. Furthermore, in order to evaluate whether modified lipid profile was associated to an increased cardiovascular risk, this was determined in the same groups. Cytokine levels were measured using ELISA in 58 patients with IUD and 52 controls. A… Show more

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Cited by 14 publications
(12 citation statements)
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References 52 publications
(56 reference statements)
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“…Active H. pylori infection was not associated with a modified lipid profile in either controls or IHD patients, although ApoAI levels were significantly higher in H. pylori ‐positive controls compared to H. pylori negative. Taken together, the results of the present study provide evidence that active H. pylori infection may play a role as a trigger factor in the pathophysiology of IHD by inducing an inflammatory cascade concentrated on gastric mucosa [2].…”
Section: Helicobacter Pylori Infectionmentioning
confidence: 55%
“…Active H. pylori infection was not associated with a modified lipid profile in either controls or IHD patients, although ApoAI levels were significantly higher in H. pylori ‐positive controls compared to H. pylori negative. Taken together, the results of the present study provide evidence that active H. pylori infection may play a role as a trigger factor in the pathophysiology of IHD by inducing an inflammatory cascade concentrated on gastric mucosa [2].…”
Section: Helicobacter Pylori Infectionmentioning
confidence: 55%
“…Our study population was relatively young (mean age: 35.2 years old), which may account for the lower infection rate. Subgroup analysis showed that the prevalence of H. pylori infection increased with age in both men (20)(21)(22)(23)(24)(25)(26)(27)(28)(29) 44.1%). Therefore, the higher prevalence was also observed in the older age groups in our study.…”
Section: Discussionmentioning
confidence: 99%
“…First, H. pylori infection impairs secretion balance of proinflammatory cytokines and CRP, angiotensinogen, free fatty acids, and leptin hormone, and thus, reactive oxygen species begin to accumulate. Subclinical chronic inflammation induced by H. pylori infection occurs via impaired cytokine balance and stimulated macrophages [ 12 , 13 ]. There are explanations that this leads to unresponsiveness to insulin in the peripheral tissue and subsequently to metabolic syndrome [ 14 17 ].…”
Section: Discussionmentioning
confidence: 99%