Serum Levels of Trace Elements in Patients with Prostate Cancer

Kaba, Mehmet; Pirinççi, Necip; Yüksel, Mehmet Bilgehan; Geçit, İlhan; Güneş, Mustafa; Ozveren, Huseyin; Eren, Hüseyin Aksel; Demır, Halit

doi:10.7314/apjcp.2014.15.6.2625

Cited by 34 publications

(35 citation statements)

References 56 publications

(49 reference statements)

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“…In our study, Zn level in ovarian cancer patients was found higher in preoperative group compared to control and postoperative group; but a statistically significance wasn't obtained. However, it can be stated that this result is compatible with the literature studies [8,10,11]. Likewise, the variations in the levels of Mg, Mn and Fe can be important markers for diagnosis and follow-up of ovarian cancer.…”

Section: Resultssupporting

confidence: 91%

“…A study revealed that Fe level in lung cancer patients was significantly higher than those of healthy control group [8]. In a research, Fe level decreased in prostate cancers [11]. This study presented that Fe level in ovarian cancer patients was found lower in preoperative group compared to those of control and postoperative group and there was statistically significant difference.…”

Section: Discussionmentioning

confidence: 74%

“…A study discovered that Mn level in lung cancer patients was significantly higher than those of healthy control group [8]. Likewise, it was revealed by a research that Mn level in prostate cancer patients was significantly higher than those of healthy control group [11]. This study revealed that Mn level in ovarian cancer patients was lower in the preoperative group than those of control and postoperative group and statistically significant.…”

Section: Discussionmentioning

confidence: 90%

“…These elements join the various structural and functional activities of organism and get involved especially in different enzyme systems and hence they play important roles for occurrence of living phenomena and survival [7]. It has been discovered by the studies on different types of cancer within literature that the levels of Zn, Mn, Cu, Mg and Fe sometimes increase and decrease [8,9,10,11]. There are a Doi: 10.17546/msd.01241 140 considerably limited number of researches regarding rare-earth elements on ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

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Examination of preoperative and postoperative levels of rare earth elements (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe in the blood of ovarian cancer patients

2015

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Objective: In this study, serum material drawn preoperatively and postoperatively from totally 33 patients who applied to Department of Gynaecology of Yüzüncü Yıl University Faculty of Medicine and Van Training and Research Hospital due to suffering from ovarian cancer was used. Material and Methods: The serum levels (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe) were determined by the method of Atomic Absorption Spectrophotometry at Spectrometer in Yüzüncü Yıl University Central Research Laboratory. The levels of rare-earth, trace and heavy elements were determined from the serum samples which were drawn from healthy and volunteer 30 women who were close to the same age group. Results: This study found out a significant difference (p<0.001) between the preoperative and postoperative levels of lead, manganese and iron in ovarian cancer patients. While a significant difference (p>0.005) wasn't discovered between the preoperative and postoperative levels of zinc, copper, cadmium and cobalt in ovarian cancer patients, a statistically significant difference was found between the preoperative and postoperative levels of magnesium (p=0.07) in those patients. Conclusion: Consequently, Zn is important in the prognosis of the disease because it is a strong antioxidant element. The elements Mg, Mn and Fe can be significant markers for ovarian cancer and especially low level of Mn may increase the risk of ovarian cancer. Also, such elements as Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe may play an important role in pathogenesis of ovarian cancer.

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Section: Resultssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Examination of preoperative and postoperative levels of rare earth elements (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe in the blood of ovarian cancer patients

2015

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“…As both of these conditions have different histopathology and clinical behaviour, different metabolic alterations should account for these pathological processes. Alterations in levels of certain trace elements especially selenium and zinc have been identified in prostate cancer [2][3][4][5]. However, administration of Se to subjects in clinical trials [6] and Zn in case control studies [7] failed to prevent the prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer

et al. 2015

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Deficiency or excess of certain trace elements has been considered as risk factor for prostate cancer. This study was aimed to detect differential changes and mutual correlations of selected trace elements in prostate cancer tissue versus benign prostatic hyperplasia tissue. Zinc, copper, iron, calcium and selenium were analysed in histologically proven 15 prostate cancer tissues and 15 benign prostatic hyperplasia tissues using atomic absorption spectrophotometer. Unpaired two tailed t test/MannWhitney U test and Pearson correlation coefficient were used to compare the level of trace elements, elemental ratios and their interrelations. As compared to benign prostatic tissue, malignant prostatic tissue had significantly lower selenium (p = 0.038) and zinc (p = 0.043) concentrations, a lower zinc/iron ratio (p = 0.04) and positive correlation of selenium with zinc (r = 0.71, p = 0.02) and iron (r = 0.76, p = 0.009). Considerably divergent interrelationship of elements and elemental ratios in prostate cancer versus benign prostatic hyperplasia was noted. Understanding of differential elemental changes and their interdependence may be useful in defining the complex metabolic alterations in prostate carcinogenesis with potential for development of element based newer diagnostic, preventive and therapeutic strategies. Further studies may be needed to elucidate this complex relationship between trace elements and prostate carcinogenesis.

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The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

Tehrani

Hosseini

Yousefi

et al. 2018

J of Cellular Biochemistry

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DNA damage response (DDR) is a regulatory system responsible for maintaining genome integrity and stability, which can sense and transduce DNA damage signals. The severity of damage appears to determine DDRs, which can include damage repair, cell‐cycle arrest, and apoptosis. Furthermore, defective components in DNA damage and repair machinery are an underlying cause for the development and progression of various types of cancers. Increasing evidence indicates that there is an association between trace elements and DDR/repair mechanisms. In fact, trace elements seem to affect mediators of DDR. Besides, it has been revealed that oxidative stress (OS) and trace elements are associated with cancer development. In this review, we discuss the role of some critical trace elements in the risk of cancer. In addition, we provide a brief introduction on DDR and OS in cancer. Finally, we will further review the interactions between some important trace elements including selenium, zinc, chromium, cadmium, and arsenic, and DDR, and OS in cancer.

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Serum Levels of Trace Elements in Patients with Prostate Cancer

Cited by 34 publications

References 56 publications

Examination of preoperative and postoperative levels of rare earth elements (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe in the blood of ovarian cancer patients

Examination of preoperative and postoperative levels of rare earth elements (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe in the blood of ovarian cancer patients

Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer

The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

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