The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

Tehrani, Sadra Samavarchi; Hosseini, Hamideh Mahmoodzadeh; Yousefi, Tooba; Abolghasemi, Maryam; Qujeq, Durdi; Maniati, Mahmood; Amani, Jafar

doi:10.1002/jcb.27617

Cited by 43 publications

(19 citation statements)

References 284 publications

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“…For instance, two of the most essential DDR regulators are ATM and ATR, the activation of which is caused by depletion of TIN2. 45,81,82 Interestingly, TIN2 can act independently of TPP1. That is, a truncated form of TIN2 lacking the TPP1 interaction can compel telomerase-dependent telomere extension.…”

Section: Tin2mentioning

confidence: 99%

<p>Shelterin Complex at Telomeres: Implications in Ageing</p>

Mir

Tehrani

Goodarzi

et al. 2020

CIA

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Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing.

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Section: Tin2mentioning

confidence: 99%

<p>Shelterin Complex at Telomeres: Implications in Ageing</p>

Mir

Tehrani

Goodarzi

et al. 2020

CIA

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“…For example, zinc and iron-containing nutrition are necessary for the formation of enzymes with zinc finger domains and with Fe/S clusters. These enzymes include a wide range of proteins involved in DNA synthesis, DNA damage response and repair, telomere maintenance, DNA methylation, histone acetylation, and other processes important for maintaining genome stability [ 132 , 927 , 928 ]. However, excessive consumption can also have a toxic effect [ 129 , 133 , 883 , 929 ].…”

Section: Pharmacological Interventions Protecting Genomementioning

confidence: 99%

Genome-Protecting Compounds as Potential Geroprotectors

Proshkina

Shaposhnikov

Moskalev

2020

IJMS

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Throughout life, organisms are exposed to various exogenous and endogenous factors that cause DNA damages and somatic mutations provoking genomic instability. At a young age, compensatory mechanisms of genome protection are activated to prevent phenotypic and functional changes. However, the increasing stress and age-related deterioration in the functioning of these mechanisms result in damage accumulation, overcoming the functional threshold. This leads to aging and the development of age-related diseases. There are several ways to counteract these changes: (1) prevention of DNA damage through stimulation of antioxidant and detoxification systems, as well as transition metal chelation; (2) regulation of DNA methylation, chromatin structure, non-coding RNA activity and prevention of nuclear architecture alterations; (3) improving DNA damage response and repair; (4) selective removal of damaged non-functional and senescent cells. In the article, we have reviewed data about the effects of various trace elements, vitamins, polyphenols, terpenes, and other phytochemicals, as well as a number of synthetic pharmacological substances in these ways. Most of the compounds demonstrate the geroprotective potential and increase the lifespan in model organisms. However, their genome-protecting effects are non-selective and often are conditioned by hormesis. Consequently, the development of selective drugs targeting genome protection is an advanced direction.

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“…To investigate the biomarkers in a variety of cancers, several markers have been recognized to identify cancers [17,18]. In this regard, it can be noted that in recent years, researchers have concentrated on the DNA damage response in cancer and some of the effective factors in the pathogenesis of the human disease [19,20]. There is increasing evidence to support the measurement of specific biomarkers in biological samples of patients with cancer [21,22].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject

et al. 2020

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Background: Currently, glycans, which are known as functional molecules in the biological system, are being under study as potential cancer markers. This study aimed to determine the level of serum L-fucose and sialic acid as the biomarkers in patients with colorectal cancer (CRC). Materials and Methods: The patients with CRC (n=40, 20 men and 20 women) participated in the present study. The spectrophotometric method was used to measure the levels of L-fucose and sialic acid in the serum of the patients. SPSS (version 21) was used to analyze the obtained data. The results were expressed as mean ± SD. Results: The mean ± SD L-fucose level in patients with CRC was 27.46 ± 4.8 ng/mL, which was more than this level in the healthy control group (18.64±3.1 ng/mL). Also, the mean ± SD serum concentration of sialic acid in patients with CRC was 2.1 ± 0.41 ng/mL, which was more than the mean ± SD sialic acid level of 1.23±0.21 ng/mL in the healthy controls. Conclusion: Serum concentration of L-fucose and sialic acid increased significantly (P < 0.05) in patients with CRC compared with the healthy controls. We believe that determining serum L-fucose and sialic acid levels could be useful for the detection of CRC patients in the early stage.

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The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

Cited by 43 publications

References 284 publications

<p>Shelterin Complex at Telomeres: Implications in Ageing</p>

<p>Shelterin Complex at Telomeres: Implications in Ageing</p>

Genome-Protecting Compounds as Potential Geroprotectors

Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject

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