Serum Levels of Interleukin-18 (IL-18), Interleukin-1β (IL-1β), its Soluble Receptor sIL-1RII and C-reactive Protein (CRP) in Patients with Lyme Arthritis

Pietruczuk, Adam; Świerzbińska, Renata; Pancewicz, Sławomir; Pietruczuk, Mirosława; Hermanowska-Szpakowicz, Teresa

doi:10.1007/s15010-006-5013-z

Cited by 16 publications

(12 citation statements)

References 16 publications

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“…All three pointed to a lack of substantially enhanced systemic CRP response in most patients with Lyme arthritis [21][22][23], in agreement with our results. A serum analysis in 20 patients with early neurologic Lyme disease reported a lack of increased CRP concentration in most [24], while a study of 44 Lyme disease patients with EM found both CRP and SAA to be significantly elevated in comparison to 23 healthy controls [25]. Our data confirm these findings as well.…”

Section: Discussionsupporting

confidence: 92%

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Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease

Uhde

Ajamian

et al. 2016

Clin Infect Dis.

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Background. Infection with Borrelia burgdorferi, the causative agent of Lyme disease, triggers host immune responses that affect the clinical outcome and are a source of biomarkers with diagnostic utility. Although adaptive immunity to B. burgdorferi has been extensively characterized, considerably less information is available about the development of innate acute-phase responses in Lyme disease. Our aim in this study was to evaluate the expression of C-reactive protein (CRP) and serum amyloid A (SAA), the prototype acute-phase response proteins, in the context of the varying manifestations associated with Lyme borreliosis.Methods. Circulating concentrations of CRP and SAA in patients with a range of early to late objective manifestations of Lyme disease and in individuals with post-treatment Lyme disease syndrome were compared with those in healthy control groups.Results. CRP and SAA levels were significantly elevated in early localized and early disseminated Lyme disease but not in the later stages of active infection. Levels of CRP, but not SAA, were also found to be significantly increased in patients with antibioticrefractory Lyme arthritis and in those with post-treatment Lyme disease syndrome.Conclusions. These findings indicate that circulating CRP and SAA levels are highest when the concentration of spirochetes is greatest in skin and/or blood and that levels decline after the dissemination of the organism to extracutaneous sites in subsequent stages of infection. The data also suggest that antibiotic-refractory Lyme arthritis and post-treatment Lyme disease syndrome are associated with elevated CRP responses that are driven by inflammatory mechanisms distinct from those in active infection.

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Section: Discussionsupporting

confidence: 92%

“…non-Lyme arthritis, without incorporating healthy controls [21,22], and one study examined CRP levels in 20 Lyme arthritis patients and 10 healthy volunteers [23]. All three pointed to a lack of substantially enhanced systemic CRP response in most patients with Lyme arthritis [21][22][23], in agreement with our results.…”

Section: Discussionsupporting

confidence: 85%

Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease

Uhde

Ajamian

et al. 2016

Clin Infect Dis.

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“…126 Curiously, the Arg112Cys and Ile164Thr mutations that prevent adiponectin from trimer formation and result in the impaired secretion of this protein from the cell were shown to be clinically associated with hypoadiponectinemia. 80 Intercellular cell adhesion molecule-1 (iCAM-1), also known as CD54 (cluster of differentiation 54), is an immunoglobulin-like glycoprotein expressed on the surface of several cell types including endothelial cells and cells involved in the immune response, 128 where it serves as a ligand for the leukocyte adhesion protein LFA-1 (integrin a-L/b-2). Besides its major role in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration, iCAM-1 serves as a site for the cellular entry of human rhinovirus 129,130 and is involved in a signal transduction 131 and spermatogenesis.…”

Section: Discussionmentioning

confidence: 99%

Intrinsic disorder in biomarkers of insulin resistance, hypoadiponectinemia, and endothelial dysfunction among the type 2 diabetic patients

Al-Jiffri

Al-Sharif

Al-Jiffri

et al. 2016

Intrinsically Disordered Proteins

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Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is strongly associated with various complications including cardiovascular diseases and related mortality. The present study aimed to analyze the abundance and functionality of intrinsically disordered regions in several biomarkers of insulin resistance, adiponectin, and endothelial dysfunction found in the T2DM patients. In fact, in comparison to controls, obese T2DM patients are known to have significantly higher levels of inter-cellular adhesion molecule (iCAM-1), vascular cell adhesion molecule (vCAM-1), and E-selectin, whereas their adiponectin levels are relatively low. Bioinformatics analysis revealed that these selected biomarkers (iCAM-1, vCAM-1, E-selectin, and adiponectin) are characterized by the noticeable levels of intrinsic disorder propensity and high binding promiscuity, which are important features expected for proteins serving as biomarkers. Within the limit of studied groups, there is an association between insulin resistance and both hypoadiponectinemia and endothelial dysfunction.

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“…A role for IL-1␤ has been suggested in Lyme borreliosis because IL-1␤ mRNA can be detected in erythema migrans lesions of patients with Lyme disease, and elevated levels of the cytokine can be found in their sera (31,35). In addition, human peripheral blood mononuclear cells secrete IL-1␤ after ingestion of live B. burgdorferi spirochetes (15).…”

Section: Discussionmentioning

confidence: 99%

“…IL-1␤, however, may play a role because human peripheral blood mononuclear cells secrete IL-1␤ after ingestion of live B. burgdorferi spirochetes (15). In support of this hypothesis, serum levels of IL-1␤ were reported to be elevated in Lyme disease patients, and the levels decreased significantly after doxycycline treatment (35). IL-1␤ mRNA levels in erythema migrans lesions were also shown to be elevated (31).…”

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confidence: 94%

The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis

et al. 2009

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The contribution of the inflammasome to the development of immune responses and disease during infection with the Lyme disease spirochete, Borrelia burgdorferi, is not well defined. Host defense against the spirochete is severely impaired in mice deficient in the adaptor molecule myeloid differentiation antigen 88 (MyD88), which is required not only for Toll-like receptor-mediated responses but also for the production of the proforms of interleukin 1␤ (IL-1␤) and IL-18. These cytokines are released in active forms after cleavage by the inflammasome-associated enzyme caspase 1. To investigate the contribution of the inflammasome to host defense against B. burgdorferi, we examined Lyme borreliosis in mice deficient in either caspase 1 or apoptosisassociated speck-like protein containing a C-terminal caspase recruitment domain (ASC), a molecule upstream of caspase 1 in the inflammasome signaling cascade. We found that caspase 1-deficient mice had a mild transient elevation in pathogen burden and a trend toward an increase in the prevalence of arthritis early in infection, but these differences resolved by day 14 postinfection. Caspase 1 deficiency had no effect on B. burgdorferi-induced humoral immunity, T-cell responses, or the abilities of macrophages to ingest and degrade spirochetes. The absence of the ASC protein had no effect on the control of the spirochete or the development of immune responses and disease. These findings reveal that the caspase 1 inflammasome is not critical to host defense against the extracellular pathogen Borrelia burgdorferi.

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Serum Levels of Interleukin-18 (IL-18), Interleukin-1β (IL-1β), its Soluble Receptor sIL-1RII and C-reactive Protein (CRP) in Patients with Lyme Arthritis

Abstract: The results of our study suggest that IL-18, IL-1beta and sIL-1RII might be involved in the development of LA. CRP may be useful in differential diagnosis in patients with suspicion of Lyme arthritis.

Cited by 16 publications

References 16 publications

Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease

Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease

Intrinsic disorder in biomarkers of insulin resistance, hypoadiponectinemia, and endothelial dysfunction among the type 2 diabetic patients

The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis

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