Serum Levels of Glycoproteins are Elevated in Patients with Ovarian Cancer

Thakkar, Vikram; Patel, Pooja; Prajapati, Neelam; Kaur, Ranjit; Nandave, Mukesh

doi:10.1007/s12291-013-0380-6

Cited by 14 publications

(12 citation statements)

References 28 publications

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“…But Petru et al [ 20 ] reports very high sensitivities values for CA-125 (90.2%) for diagnosing Ovarium cancer. These high values have not been replicated by other studies [ 21 – 23 ]. For instance, Li et al [ 21 ], found that the combined determination of SA with hydroxyproline provides a better diagnosis value than either CA-125 or HE4.…”

Section: Discussioncontrasting

confidence: 78%

“…S. Ghosh [ 22 ] discusses in a recent work, how SA in serum may also be used as a clinical predictor for Ovarium cancer. Finally, we add that Thakkar et al [ 23 ] found that protein-bound sialic acid (PBSA) provides the highest overall ability to discriminate between ovarian cancer patients and healthy subjects, in comparison with other glycoproteins in serum [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

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Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases

et al. 2018

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BackgroundTo demonstrate the use of surface-enhanced Raman spectroscopy (SERS) to determine sialic acid (SA) levels in saliva using silver nanoparticles as substrates, in adnexal mass patients scheduled for surgical intervention to remove invasive masses, with the aim to compare SA levels in benign tumor vs ovarian cancer patients.MethodsQuantification of SA levels was accomplished by measuring their SERS and calibrating with analytical reagent SA. The mean SA concentration in saliva from 37 benign adnexal mass resulted smaller (5.1 mg/dL) than the mean concentration in 15 Ovarium cancer patients (23 mg/dL). The cancer condition was determined by biopsy of the removed adnexal mass. The CA-125 biomarker was also measured. The predictive potential of both biomarkers is discussed, together with the malignity risk index (MRI).ResultsOur results showed a sensitivity/specificity of 80%/100% with a cutoff to distinguish between benign/cancer cases of SA 15.5 mg/dL, as established from a ROC analysis. Our results suggest that SA may be a more useful biomarker than CA-125 to detect ovarian cancer.ConclusionsOur results suggest that the SA levels measured from saliva may be as good predictors as the MRI index for the presence of ovarian cancer in sensitivity/negative predictive value and outperforms it in specificity/positive predictive value.Electronic supplementary materialThe online version of this article (10.1186/s13048-018-0433-9) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases

et al. 2018

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“…As an important protein, glycoproteins exhibit great significance as cancer biomarkers . It was reported that the mean level of serum glycoproteins for normal subjects and Patients of ovarian cancer was ∼113.2 (86.00–131.06) mg % and 228.7 (180.63–260.48) mg %, respectively .…”

Section: Enzyme Effectmentioning

confidence: 99%

Recent Advances in the Construction of Biofuel Cells Based Self‐powered Electrochemical Biosensors: A Review

Liu

et al. 2018

Electroanalysis

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The application of biofuel cells (BFCs) for the construction of self‐powered electrochemical biosensors has recently received enormous attention with exciting advancements. The principle of BFCs for electrochemical biosensing is that the BFCs’ power output which is directly extracted by the biological reactions with the help of biocatalysts is closely related to the analyte's concentration. Such unique feature makes BFCs based electrochemical biosensors with two‐electrode system to be operated without the need of any external power source, which provides a more effective way for the miniaturization and convenient construction of electrochemical biosensors than the traditional electrochemical biosensors with three‐electrode system. Following our previous reviews (Electroanalysis 2012, 24, 197–209; Electroanalysis 2015, 27, 1786–1801), the current review is focused on the recent development and advances in the construction of BFCs based self‐powered electrochemical biosensors which are reported in the years between 2015 and 2018, with a particular emphasis on their possible practical applications in the fields of medical diagnosis, environmental monitoring, food analysis and wearable devices. For these reported BFCs‐based self‐powered electrochemical biosensors, the design approaches are still within the scope of effects (i.e., substrate, inhibition, blocking, gene regulation, enzyme, co‐stabilization, competition, and hybrid effects) summarized by our previous reviews. The outlook, challenges and developing tendency of the future research for the construction of BFCs based self‐powered electrochemical biosensor are discussed in the end. We expect that the advanced electrochemical biosensors based on BFCs with the unique self‐powered capability will continue attracting increasing research interest and lead to new opportunities in various attractive applications related to analytical chemistry.

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“…They are present in the extracellular matrix and believed to contribute to the structure of the matrix. They play an important role in tissue stabilization and are found as hormones, blood group substances (13,46). Their levels are important for determining many diseases like tuberculosis (47), autoimmune thyroiditis (48), diabetes mellitus (49) and hepatotoxicity (50).…”

Section: Turkyilmaz and Yanardagmentioning

confidence: 99%

Vitamin U ameliorates glycoprotein components, enzyme and tissue factor activities of amiodarone toxicity in liver

Türkyılmaz

Yanardağ

2016

Marmara Pharm J

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In this study, we aimed to investigate the protective effect of Vitamin U (Vit U) on amiodarone (AMD)-induced hepatotoxicity. Male Sprague-Dawley rats were randomly divided into four groups. Group I was control animals receiving corn oil for 7 days, Group II consisted of animals receiving Vit U (50 mg/kg) for 7 days, Group III consisted of animals receiving AMD (100 mg/kg) for 7 days and Group IV consisted of animals given AMD and Vit U (in same dose and time). AMD and Vit U were administered to rats by gavage. On the 8th day, all the animals fasted overnight were sacrificed. Blood and liver tissue samples were taken from animals. Serum total cholesterol levels and liver gamma glutamyl transferase (transpeptidase) adenosine deaminase and tissue factor activities, liver glycoprotein component level such as fucose, hexose and hexosamine were determined. All the parameters were found to be increased in AMD group as compared to control group. Administration of Vit U reversed these effects in AMD group. According to these results, we can conclude that Vit U can prevent AMD-induced liver injury.

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Serum Levels of Glycoproteins are Elevated in Patients with Ovarian Cancer

Cited by 14 publications

References 28 publications

Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases

Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases

Recent Advances in the Construction of Biofuel Cells Based Self‐powered Electrochemical Biosensors: A Review

Vitamin U ameliorates glycoprotein components, enzyme and tissue factor activities of amiodarone toxicity in liver

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