Serum Levels of Calcification Inhibitors in Patients With Intracerebral Hemorrhage

Abstract

The vascular calcification regulators and inflammatory markers including fetuin-A, osteopontin (OPN), and matrix Gla protein (MGP) may play an important role in the development of intracerebral hemorrhages (ICHs). So far, the relationship between these parameters and ICH has not been studied. Therefore, this study was designed to elucidate whether fetuin-A, MGP, and OPN are involved in the pathophysiology of ICH. The ICH group consisted of 27 consecutive patients with spontaneous ICH evaluated in the neurology intensive care unit within the first 24 hours from the onset of the stroke. The serum OPN levels were significantly increased in patients with ICH compared to the controls. On the other hand, the serum MGP and fetuin-A levels were significantly decreased in the patients with ICH in comparison to the controls. In the patients with ICH, the serum MGP levels of the nonsurvivors were statistically significantly lower than the MGP levels of the survivors. In conclusion, the change in serum fetuin-A, MGP, and OPN levels after ICH indicates that these parameters play a role in the pathophysiological processes leading to an ICH. Measurement of the serum MGP levels may also be of value to estimate mortality.

Serum fetuin-A levels in subjects with and without choroid plexus calcification

“…Fetuin-A levels were significantly decreased in patients with ICH in comparison to the controls. Decreased fetuin-A levels in the patients who had an ICH support the hypothesis that inflammatory processes and/or vascular calcifications play a role in the pathogenesis of this condition [12]. In Alzheimer disease (AD), Geroldi et al showed that fetuin-A concentrations in CSF of AD patients were consistently lower than the levels in the CSF taken from non-demented controls.…”

“…On the other hand, fetuin-A also acts as a negative acute-phase protein and enhance phagocytosis of apoptotic cells by monocyte-derived macrophages [11]. Furthermore, there are various studies conducted on patients with neurodegenerative diseases, multiple sclerosis, intracerebral hemorrhage and ischemic stroke showing association of fetuin-A with central nervous system pathologies [12][13][14][15]. There is no report in the literature investigating the possible connection between fetuin-A levels and CP calcification.…”

The polymorphism of matrix Gla-protein gene in ischemic atherothrombotic stroke patients

“…Acar і співавт. [4] встановили, що у хворих з геморагічним інсультом концентрація MGP у сироватці крові набагато менша, ніж у контрольній групі. Крім того, цей показник у хворих, що померли внаслідок крововиливу у мозок, був достовірно нижчим, ніж у тих, хто вижив.…”

Association Between Alkaline Phosphatase and Clinical Outcomes in Patients With Spontaneous Intracerebral Hemorrhage

“…However, the role of ALP on clinical outcomes of ICH patients has not been fully interpreted in previous studies conducted in a single center with relatively small cohort, and the underlying mechanism remains unclear. Some suggested that vascular dysfunction and atherosclerotic process may play a crucial role in ICH clinical outcomes ( 16 , 18 ).…”