Serum fetuin-A levels in subjects with and without choroid plexus calcification

Ceylan, Mustafa; Bayraktutan, Omer Faruk; Atis, Omer; Yalçın, Ahmet; Kotan, Dilcan; Yılmaz, Tülay

doi:10.1016/j.neulet.2015.01.047

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…The level of fetuin-A, which is a marker of inflammation, is significantly higher in patients with CPC (Ceylan et al 2015). Similarly, we show here that SPA in subjects with CPC was significantly increased compared with that in controls, suggesting that CPC developed because of inflammation.…”

Section: Discussionsupporting

confidence: 75%

“…Electron microscopy of CP reveals precipitates of calcium (Ca) in the subepithelial regions and in the walls of blood vessels, but they are mainly observed in spherical psammoma bodies (Alcolado et al 1986). The most important factors associated with the occurrence of tissue calcification are as follows: extracellular matrix (ECM) suitable for mineralization, extracellular levels of inorganic phosphate (P) and Ca, and levels of mineralization inhibitors that may be systemically or locally expressed (Brylka and Jahnen-Dechent 2013;Ceylan et al 2015). CP degeneration may result in low CSF production and hyperthermic brain injury in animals.…”

Section: Introductionmentioning

confidence: 99%

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Serum Prolidase Activity as a Biomarker for Choroid Plexus Calcification

Kaleli

Kotan

Akdoğan

et al. 2016

Tohoku J. Exp. Med.

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The choroid plexus (CP) performs multiple functions such as secretion and reabsorption. CP also acts as the blood-cerebrospinal fluid barrier. Prolidase plays an important role in collagen metabolism by degrading imidodipeptides, in which proline or hydroxyproline residue is located at the C-terminal end. Serum prolidase activity (SPA) may reflect the degree of fibrosis and inflammation. Choroid plexus calcification (CPC) is considered as the physiological calcification of the brain, and CPC is diagnosed by the presence of calcification in the anatomical region on computed tomography (CT). Here, CPC and non-calcified CP were defined by Hounsfield Units (HU) values of > 150 and < 50, respectively. We aimed to measure SPA in subjects with CPC and those with non-calcified CP. This study included 89 subjects who were admitted to the neurology clinic and underwent CT: 44 subjects with CPC and 45 subjects with non-calcified CP. The neurological examination of all subjects was normal; namely, the subjects with CPC were asymptomatic. The SPA level was significantly higher in the CPC group than that in the non-calcified CP group (p < 0.002), and there was a significant positive correlation between vitamin D and SPA levels in the CPC group. In contrast, the vitamin D and parathyroid hormone levels were higher in the CPC group, but the difference was not statically significant (p > 0.05). These findings indicate that SPA is a biomarker for CPC that may be predictive of future brain disease.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Serum Prolidase Activity as a Biomarker for Choroid Plexus Calcification

Kaleli

Kotan

Akdoğan

et al. 2016

Tohoku J. Exp. Med.

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“…The relationship of fetuin-A levels, which has another calcification inhibitor and inflammatory effects, with CP calcification was examined and serum fetuin-A levels were found to be lower in patients with CP calcification compared to those without CP calcification. 12 Similarly, in our study, serum levels of OPN, which is a calcification inhibitor, were significantly lower in those with CP calcification compared to those without CP calcification. Our findings support the role of OPN in CP calcification.…”

Section: Discussionsupporting

confidence: 73%

“…10 The levels of extracellular inorganic phosphate (P), calcium (Ca), systemically or locally secreted mineralization inhibitors and extracellular matrix (ECM) suitable for mineralization are important factors in tissue calcification. 11,12 OPN exists as both a component of the extracellular matrix and a soluble cytokine. OPN expression in adults is normally limited to bone, kidney, and epithelium, and it is secreted in body fluids including blood, urine, and milk.…”

Section: Introductionmentioning

confidence: 99%

Low serum osteopontin levels in individuals with choroid plexus calcification

Yevgi¹,

Bilge²,

Şimşek³

et al. 2022

NeuroAsia

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Background & Objective: The choroid plexus (CP) is a tissue plexus located in the ventricles that produces hormones and nutrients, primarily cerebrospinal fluid (CSF). CP is also an important component of the blood CSF barrier. Osteopontin (OPN) is an extracellular matrix protein that plays a role in various physiological and pathological conditions such as bone reshaping, wound healing, vascular disorders, and inflammatory diseases. It is considered that OPN physiologically regulate bio- mineralization in bone tissue and reduce the growth and accumulation of calcium crystals in epithelial tissues. In our study, the role of OPN in CP calcification was studied. Methods: A total of 90 people, without any disease but with CP calcification (45 people) and age and gender matched control without CP calcification (45 people) were studied. Calcified and normal CP tissue was identified in brain computed tomography (CT) images. Serum OPN levels were measured in individuals with and without CP calcification using a human OPN enzyme-linked immunosorbent test kit (ELISA) from morning fasting venous blood samples. Results: Serum OPN level was found to be statistically significantly lower in patients with CP calcification than those without CP calcification (p=0.007). Conclusions: Our results show that OPN may have a significant role in the calcification process of CP.

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