Abstract:Objective To compare the level of vitamin D3 in cutaneous melanoma patients, with or without disease activity, with reference values and with patients from a general hospital.Methods The serum levels of vitamin D3 were measured in cutaneous melanoma patients, aged 20 to 88 years, both genders, from January 2010 to December 2013. The samples from the general group were processed at Hospital Israelita Albert Einstein (control group). Data analysis was performed using the Statistics software.Results A total of 10… Show more
“…This was possibly, in part due to Filho et al ., which showed, quite different from most other studies, significantly higher vitamin D levels in patients with melanoma than those levels in controls. However, the exclusion and inclusion criteria of controls were not elaborated in this study, and the control group comprised ‘general patients’ instead of healthy controls . This limitation may contribute to substantial bias because a large number of studies have revealed vitamin D deficiency in various diseases .…”
Section: Discussioncontrasting
confidence: 80%
“…Of note, although there was no significant difference in the serum vitamin D levels between patients with melanoma and controls, the heterogeneity of this analysis was extremely high. This was possibly, in part due to Filho et al ., which showed, quite different from most other studies, significantly higher vitamin D levels in patients with melanoma than those levels in controls. However, the exclusion and inclusion criteria of controls were not elaborated in this study, and the control group comprised ‘general patients’ instead of healthy controls .…”
Section: Discussioncontrasting
confidence: 80%
“…However, the exclusion and inclusion criteria of controls were not elaborated in this study, and the control group comprised 'general patients' instead of healthy controls. 20 This limitation may contribute to substantial bias because a large number of studies have revealed vitamin D deficiency in various diseases. 21,22 Leave-one-study-out sensitivity analysis showed that excluding the results of Filho et al led to a significant difference in serum vitamin D levels between patients with melanoma and controls.…”
Background Vitamin D has antineoplastic effects, but the synthesis of vitamin D requires ultraviolet radiation, a known risk factor for melanoma. Objective To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma. Methods A systematic review and meta-analysis were conducted. Online databases were searched on 31 Oct 2018. Results Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls [standardized mean difference (SMD), À0.185; 95% confidence interval (CI), À0.533 to 0.162]. However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151-3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (≦1 vs. >1 mm: SMD, 0.243; 95% CI, 0.160-0.327). Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258-1.931). Conclusions Vitamin D deficiency is associated with higher Breslow thickness and mortality in melanoma patients.
“…This was possibly, in part due to Filho et al ., which showed, quite different from most other studies, significantly higher vitamin D levels in patients with melanoma than those levels in controls. However, the exclusion and inclusion criteria of controls were not elaborated in this study, and the control group comprised ‘general patients’ instead of healthy controls . This limitation may contribute to substantial bias because a large number of studies have revealed vitamin D deficiency in various diseases .…”
Section: Discussioncontrasting
confidence: 80%
“…Of note, although there was no significant difference in the serum vitamin D levels between patients with melanoma and controls, the heterogeneity of this analysis was extremely high. This was possibly, in part due to Filho et al ., which showed, quite different from most other studies, significantly higher vitamin D levels in patients with melanoma than those levels in controls. However, the exclusion and inclusion criteria of controls were not elaborated in this study, and the control group comprised ‘general patients’ instead of healthy controls .…”
Section: Discussioncontrasting
confidence: 80%
“…However, the exclusion and inclusion criteria of controls were not elaborated in this study, and the control group comprised 'general patients' instead of healthy controls. 20 This limitation may contribute to substantial bias because a large number of studies have revealed vitamin D deficiency in various diseases. 21,22 Leave-one-study-out sensitivity analysis showed that excluding the results of Filho et al led to a significant difference in serum vitamin D levels between patients with melanoma and controls.…”
Background Vitamin D has antineoplastic effects, but the synthesis of vitamin D requires ultraviolet radiation, a known risk factor for melanoma. Objective To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma. Methods A systematic review and meta-analysis were conducted. Online databases were searched on 31 Oct 2018. Results Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls [standardized mean difference (SMD), À0.185; 95% confidence interval (CI), À0.533 to 0.162]. However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151-3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (≦1 vs. >1 mm: SMD, 0.243; 95% CI, 0.160-0.327). Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258-1.931). Conclusions Vitamin D deficiency is associated with higher Breslow thickness and mortality in melanoma patients.
“…Similar condition was also reported by others in AR patients , allergic conjunctivitis , and asthma . Besides allergic disorders, VitD3 abnormality was also found associating with rheumatoid arthritis , diabetes , and cancer .…”
VitD deficiency may contribute to the pathogenesis of AR by increasing the TIM4 expression. The results suggest that to regulate the serum calcitriol levels and the expression of VDR in DCs may be necessary to be taken into account in the treatment of AR.
“…Results of this study indicate no statistically significant association between serum 25(OH)D levels and melanoma [ 70 ], although there is a suggested protective association in the second quartiles compared to the lowest levels [ 70 ]. Another recent study showed no direct relationship between high or low levels of vitamin D and the occurrence and severity of melanoma [ 71 ]. Furthermore, several studies demonstrated that VDR expression in melanoma cells is more intense than in normal melanocytes [ 72 , 73 ].…”
A tremendous amount of information was published over the past decades in relation to the role of vitamins in various neoplastic diseases. In particular, several studies showed an inverse relationship between selected vitamins intake and cancer risk. In this review we will focus on the role played by vitamins in melanoma with particular regard to vitamin A, D, K, E and C. Given that vitamin supplementation is easy, convenient, and readily accepted by patients, in the future the use of vitamins in chemoprevention and therapy of melanoma could be encouraged if supported by pre-clinical and clinical evidence.
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