Serum leptin, adiponectin and ghrelin concentrations in post-menopausal women: Is there an association with bone mineral density?

Mpalaris, Vassilis; Anagnostis, Panagiotis; Anastasilakis, Athanasios D.; Goulis, Dimitrios G.; Doumas, Argyrios; Iakovou, Ioannis

doi:10.1016/j.maturitas.2016.03.004

Cited by 33 publications

(19 citation statements)

References 29 publications

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“…In a longitudinal study performed for 12 months on healthy physically active postmenopausal women, Jürimäe et al (2009) observed an increase in plasma Adiponectin levels in relation to a decrease in BMD, indicating a role of Adiponectin in a body mineral setting. A similar result was found in untrained post-menopausal women after a 12-month long study (Mpalaris et al, 2016). Likewise, Adiponectin was considered a negative independent predictor of lumbar spine BMD in healthy or obese untrained girls (Misra et al, 2007;Jürimäe et al, 2009;Russell et al, 2009;Miazgowski et al, 2012).…”

Section: Physical Exercise and Bone Metabolismsupporting

confidence: 74%

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

et al. 2020

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Exercise represents the most important integrative therapy in metabolic, immunologic and chronic diseases; it represents a valid strategy in the non-pharmacological intervention of lifestyle linked diseases. A large body of evidence indicates physical exercise as an effective measure against chronic non-communicable diseases. The worldwide general evidence for health benefits are both for all ages and skill levels. In a dysregulated lifestyle such as in the obesity, there is an imbalance in the production of different cytokines. In particular, we focused on Adiponectin, an adipokine producted by adipose tissue, and on Orexin-A, a neuropeptide synthesized in the lateral hypothalamus. The production of both Adiponectin and Orexin-A increases following regular and structured physical activity and both these hormones have similar actions. Indeed, they improve energy and glucose metabolism, and also modulate energy expenditure and thermogenesis. In addition, a relevant biological role of Adiponectin and Orexin A has been recently highlighted in the immune system, where they function as immune-suppressor factors. The strong connection between these two cytokines and healthy status is mediated by physical activity and candidates these hormones as potential biomarkers of the beneficial effects induced by physical activity. For these reasons, this review aims to underly the interconnections among Adiponectin, Orexin-A, physical activity and healthy status. Furthermore, it is analyzed the involvement of Adiponectin and Orexin-A in physical activity as physiological factors improving healthy status through physical exercise.

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Section: Physical Exercise and Bone Metabolismsupporting

confidence: 74%

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

et al. 2020

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“…However, its effects on bone are controversial. The in vitro data support a positive osteoblast-dependent action for leptin on osteoblast proliferation and differentiation while inhibiting osteoclastogenesis, and has been confirmed by the in vivo experiments using murine models [36,37]. However, these experiments also suggest that leptin regulates bone metabolism via the central nervous system by suppressing bone formation while increasing resorption [36].…”

Section: Factors Affecting Bone Cell Fate In Obesitymentioning

confidence: 65%

“…The role of adipokines, particularly leptin and adiponectin, on bone metabolism has been examined in human and animal studies [32–37]. Leptin, a peptide hormone secreted by white adipose tissue, acts on the brain to control food intake and energy metabolism and in the absence of obesity, there is greater sensitivity to leptin with aging.…”

Section: Factors Affecting Bone Cell Fate In Obesitymentioning

confidence: 99%

Obesity is a concern for bone health with aging

2017

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Accumulating evidence supports a complex relationship between adiposity and osteoporosis in overweight/obese individuals, with local interactions and endocrine regulation by adipose tissue on bone metabolism and fracture risk in elderly populations. This review was conducted to summarize existing evidence to test the hypothesis that obesity is a risk factor for bone health in aging individuals. Mechanisms by which obesity adversely affects bone health are believed to be multiple, such as an alteration of bone-regulating hormones, inflammation, oxidative stress, the endocannabinoid system, that affect bone cell metabolism are discussed. In addition, evidence on the effect of fat mass and distribution on bone mass and quality is reviewed together with findings relating energy and fat intake with bone health. In summary, studies indicate that the positive effects of body weight on bone mineral density cannot counteract the detrimental effects of obesity on bone quality. However, the exact mechanism underlying bone deterioration in the obese is not clear yet and further research is required to elucidate the effect of adipose depots on bone and fracture risk in the obese population.

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“…The excess of adipose tissue has been traditionally considered a protector against fractures, because obesity is associated with higher BMD and the soft tissue padding has a protective effect against fall injuries [39]. Nevertheless, obesity seems to affect bone health through different mechanisms, such as changes in bone-regulating hormones such as leptin and adiponectin [40], increased oxidative stress, and compromised bone quality, possibly leading to structural bone damage and increased risk of fracture [41, 42]. In addition, the influence of high BMI on fracture risk varies according to skeletal site and is partially independent from BMD [41, 43].…”

Section: Discussionmentioning

confidence: 99%

Bone Mass Effects of Cross-Sex Hormone Therapy in Transgender People: Updated Systematic Review and Meta-Analysis

Fighera

Ziegelmann

Silva

et al. 2019

Journal of the Endocrine Society

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Context The impact of long-term cross-sex hormone therapy (CSHT) in transgender men and women is still uncertain. Objective To perform a systematic review and meta-analysis and update the evidence regarding the effects of CSHT on bone mineral density (BMD) in transgender men and women. Data Sources Medline, Cochrane Central Register of Controlled Trials, and Embase were searched for studies published until August 2018. Study Selection Of 10,849 studies, 19 were selected for systematic review. All included patients were aged >16 years and received CSHT with BMD assessment by dual-energy X-ray absorptiometry (DXA). Data Extraction Data on BMD, CSHT, and clinical factors affecting bone mass were collected. A National Institutes of Health scale was used to assess the quality of studies. Data Synthesis Nineteen studies were meta-analyzed (487 trans men and 812 trans women). In trans men, mean BMD difference compared with natal women was not significant in any site in either cross-sectional or before-after studies. In trans women, mean BMD difference was not significant compared with natal men at the femoral neck, total femur, and lumbar spine in cross-sectional studies; before-after studies reported a slight but significant increase in lumbar spine BMD after 12 and ≥24 months of treatment. Conclusions Long-term CSHT had a neutral effect on BMD in transgender men. In transgender women, only lumbar spine BMD seemed to be affected after CSHT. This evidence is of low to moderate quality as a result of the observational design of studies, small sample sizes, and variations in hormone therapy protocols.

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Serum leptin, adiponectin and ghrelin concentrations in post-menopausal women: Is there an association with bone mineral density?

Cited by 33 publications

References 29 publications

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

Obesity is a concern for bone health with aging

Bone Mass Effects of Cross-Sex Hormone Therapy in Transgender People: Updated Systematic Review and Meta-Analysis

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