Serum Lactate Dehydrogenase (LDH) Level in Severe Preeclampsia

Afroz, Rukhsana; Akhter, Qazi Shamima; Sadia, Halima; Sultana, Sharmin

doi:10.3329/jbsp.v10i2.27168

Cited by 8 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,12 Also present result supported by many studies concluded that elevated high serum LDH levels significantly correlate with the severity of preeclampsia. [13][14][15] But some studies did not find significant difference of serum LDH level between preeclamptic women and healthy pregnant women. 16,17 In the present study we found that 90% of preeclamptic women had normal levels of GGT <25 IU/L.…”

Section: Discussionmentioning

confidence: 99%

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Elias

Eltom

Osman

et al. 2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks post-partum. Pre-eclampsia is a syndrome with multiple aetiologies which has made it difficult to develop adequate screening tests and treatments. Objective of this study to assess the level of gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia in Sudanese pregnant women.Methods: This is a case control hospitalize base study. The study was conducted in preeclamptic pregnant women in Omdurman maternity hospital and medical military hospital in Khartoum state. In this study glutamyl transferase and lactate de-hydrogenase was estimation in 100 Sudanese pregnant women by spectrophotometer method, 50 of them were diagnosed with preeclampsia 27 from this is severe preeclampsia and 23 is mild preeclampsia was matched in aged. Serum samples of all the cases were assayed for GGT and LDH. The data was recorded and analyzed using statistical package for social sciences (SPS –version 16) on programmed computer. The mean standard deviations of variable were calculated for both the test group and the control group and P value for comparison was obtained.Results: The mean values of plasma gamma glutamyl transferase in mild and severe preeclamptic pregnant women were insignificant difference when compared to control P value (0.346 - 0.089) respectively. The mean values of plasma lactate dehydrogenase in mild and severe preeclamptic pregnant women were significant increase when compared to control P value (0.008 - 0.001) respectively.Conclusions: The levels of LDH is raised in Sudanese pregnant women with hypertensive also can be useful biochemical marker that reflects the severity of and the occurrence of complications of pre-eclampsia. GGT levels were normal in Sudanese pregnant women with hypertensive preeclampsia.

show abstract

Section: Discussionmentioning

confidence: 99%

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Elias

Eltom

Osman

et al. 2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Catanzerite et al [10] reported a subgroup of patients who had elevated levels of LDH manifested with hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome and were at a high risk for developing maternal mortality. Afroz et al [11] concluded that there was a statistically significant relation between maternal complications and high LDH levels. It was noted that in early onset severe preeclampsia, LDH levels before delivery were significantly higher in the abruption group.…”

Section: Discussionmentioning

confidence: 98%

Comparison of serum LDH in preeclampsia versus normotensive pregnant women

Jamwal¹,

Gupta²

2020

Int. J. Clin. Obstet. Gynaecol.

View full text Add to dashboard Cite

Background: Hypertensive disorders of pregnancy, particularly pre-eclampsia, are responsible for 10% to 15% of maternal deaths. The present study was conducted to compare LDH in preeclampsia versus normotensive pregnant women. Materials & Methods:The present study was conducted on 120 pre-eclampsia pregnant women age ranged 18-36 years of third trimester. Equal number of healthy women (group I) was taken as control. Patients were divided into mild preeclampsia (60) (group II-SBP >140 to <160mm Hg, DBP >90 to < 110 mm Hg) and severe preeclampsia patients (60) (group III-SBP > 160mm Hg, DBP > 110mm Hg). In all patients LDH level, BMI and proteinuria was determined. Results: Serum LDH level was significantly higher in preeclamptics compared to those of control. LDH was significantly higher in severe preeclamptics than those of mild preeclamptics. Conclusion: Authors found that there was significantly higher level of LDH in eclampsia and preeclampsia women as compared to normotensive women.

show abstract

“…It has also been shown that LDH can be used as a biomarker for the diagnosis of PE and an effective marker for prognostication ( 40 ). Moreover, multiorgan dysfunction caused by vascular endothelial injury in PE can lead to a large leakage of LDH, and cellular dysfunction leads to increased serum LDH levels ( 41 ). Some scholars ( 42 ) found that the sensitivity of diagnosing PE was 0.838 and the specificity was 0.714, when LDH was at the critical level of 250 U/L.…”

Section: Discussionmentioning

confidence: 99%

Pre-pregnancy body mass index combined with peripheral blood PLGF, DCN, LDH, and UA in a risk prediction model for pre-eclampsia

Zhou,

Xiao,

Yang

2024

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveThis study analyzes the levels of peripheral blood placental growth factor (PLGF), body mass index (BMI), decorin (DCN), lactate dehydrogenase (LDH), uric acid (UA), and clinical indicators of patients with preeclampsia (PE), and establishes a predictive risk model of PE, which can provide a reference for early and effective prediction of PE.Methods81 cases of pregnant women with PE who had regular prenatal checkups and delivered in Jinshan Branch of Shanghai Sixth People’s Hospital from June 2020 to December 2022 were analyzed, and 92 pregnant women with normal pregnancies who had their antenatal checkups and delivered at the hospital during the same period were selected as the control group. Clinical data and peripheral blood levels of PLGF, DCN, LDH, and UA were recorded, and the two groups were subjected to univariate screening and multifactorial logistic regression analysis. Based on the screening results, the diagnostic efficacy of PE was evaluated using the receiver operating characteristic (ROC) curve. Risk prediction nomogram model was constructed using R language. The Bootstrap method (self-sampling method) was used to validate and produce calibration plots; the decision curve analysis (DCA) was used to assess the clinical benefit rate of the model.ResultsThere were statistically significant differences in age, pre-pregnancy BMI, gestational weight gain, history of PE or family history, family history of hypertension, gestational diabetes mellitus, and history of renal disease between the two groups (P < 0.05). The results of multifactorial binary logistic stepwise regression revealed that peripheral blood levels of PLGF, DCN, LDH, UA, and pre-pregnancy BMI were independent influences on the occurrence of PE (P < 0.05). The area under the curve of PLGF, DCN, LDH, UA levels and pre-pregnancy BMI in the detection of PE was 0.952, with a sensitivity of 0.901 and a specificity of 0.913, which is better than a single clinical diagnostic indicator. The results of multifactor analysis were constructed as a nomogram model, and the mean absolute error of the calibration curve of the modeling set was 0.023, suggesting that the predictive probability of the model was generally compatible with the actual value. DCA showed the predictive model had a high net benefit in the range of 5% to 85%, suggesting that the model has clinical utility value.ConclusionThe occurrence of PE is related to the peripheral blood levels of PLGF, DCN, LDH, UA and pre-pregnancy BMI, and the combination of these indexes has a better clinical diagnostic value than a single index. The nomogram model constructed by using the above indicators can be used for the prediction of PE and has high predictive efficacy.

show abstract

Serum Lactate Dehydrogenase (LDH) Level in Severe Preeclampsia

Cited by 8 publications

References 12 publications

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Comparison of serum LDH in preeclampsia versus normotensive pregnant women

Pre-pregnancy body mass index combined with peripheral blood PLGF, DCN, LDH, and UA in a risk prediction model for pre-eclampsia

Contact Info

Product

Resources

About