Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Abstract

Background: Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks post-partum. Pre-eclampsia is a syndrome with multiple aetiologies which has made it difficult to develop adequate screening tests and treatments. Objective of this study to assess the level of gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia in Sudanese pregnant women.Methods: This is a case control hospitalize base study. The study was conducted in preeclamptic pregnant women in Omdurman maternity hospital and medical military hospital in Khartoum state. In this study glutamyl transferase and lactate de-hydrogenase was estimation in 100 Sudanese pregnant women by spectrophotometer method, 50 of them were diagnosed with preeclampsia 27 from this is severe preeclampsia and 23 is mild preeclampsia was matched in aged. Serum samples of all the cases were assayed for GGT and LDH. The data was recorded and analyzed using statistical package for social sciences (SPS –version 16) on programmed computer. The mean standard deviations of variable were calculated for both the test group and the control group and P value for comparison was obtained.Results: The mean values of plasma gamma glutamyl transferase in mild and severe preeclamptic pregnant women were insignificant difference when compared to control P value (0.346 - 0.089) respectively. The mean values of plasma lactate dehydrogenase in mild and severe preeclamptic pregnant women were significant increase when compared to control P value (0.008 - 0.001) respectively.Conclusions: The levels of LDH is raised in Sudanese pregnant women with hypertensive also can be useful biochemical marker that reflects the severity of and the occurrence of complications of pre-eclampsia. GGT levels were normal in Sudanese pregnant women with hypertensive preeclampsia.

Diagnostic performance of lactate dehydrogenase as a potential biomarker in predicting preeclampsia and associated factors

“…Another research undertaken in India reported mean serum level of LDH to be 513.37 ± 203.44 and 261 ± 78.47 in preeclamptic and healthy controls, respectively. In addition, a study done in Ethiopia reported mean level of serum LDH in preeclamptic study groups to be 353 ± 132.8 which was slightly lower than the finding of the present study (8,24,25). This observed discrepancy might possibly be due to the lowering effects of antihypertensive drugs, which were being taken by some of our study subjects.…”

“…In our study, the AUC for serum LDH, measuring its overall performance to predict development of preeclampsia, was 0.963, and its optimal cut-off point was found to be 376.5 U/L having a sensitivity and specificity of 87.5 and 90.8%, respectively. This finding was higher than a research conducted in India on similar subjects which found AUC for serum LDH to be 0.813, with sensitivity and specificity of 83.8 and 58%, respectively, at 250 U/L as cut-off value, and a study done in Iran which reported AUC for serum LDH 0.805 at an optimal cut-off point of 336 U/L with high sensitivity and moderate specificity (89.62 and 59.3% respectively) (15,25). On the contrary, a study done by Khalil et al in Saudi Arabia reported sensitivity of LDH to identify severe preeclampsia as 100%.…”

Protective Effect of Time-Modulated Cimetidine on Methotrexate-induced Liver Toxicity

“…Also, serum activities of CT, TB, LDH, and GGT correlate with liver function and elevated activities are observed in Table 2. Effect of cimetidine on liver tissue biochemical indices of methotrexate-treated rats hepatic disorders [31]. The serum and liver activities of CT, CB, AST, GGT, ALT, LDH, and ALP were high in rats treated with MTX.…”