Serum ischemia-modified albumin as a novel marker of ovarian torsion: An experimental study

Aran, Turhan; Güven, Süleyman; Ünsal, Mesut A.; Alver, Ahmet; Menteşe, Ahmet; Yuluğ, Esin

doi:10.1016/j.ejogrb.2010.01.006

Cited by 24 publications

(36 citation statements)

References 17 publications

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“…In our previous experimental study, we also researched the diagnostic value of IMA in an ovarian torsion model and determined that the ovarian torsion group had significantly higher serum IMA levels than the control group [4]. Here we performed the clinical study of IMA in human subjects and the results of our study suggest that serum levels of IMA are a good, valuable biomarker of ovarian torsion, with high sensitivity and specificity values.…”

Section: Discussionmentioning

confidence: 97%

“…This ischemic condition may lead to an increased secretion of oxidative stress markers into the general circulation. This knowledge of ovarian torsion suggested that we contemplate the hypothesis that ‘oxidative stress markers may be used in an early diagnosis of ovarian torsion' [4]. MDA, TAS, TOS, and IMA are all involved in the ischemic process.…”

Section: Discussionmentioning

confidence: 99%

“…This measurement has been described in detail in our previous study [4]. In our laboratory, the albumin-binding capacity assay within-run percent coefficient of variation (CV%) of patient samples averaged 2.1% [11].…”

Section: Methodsmentioning

confidence: 99%

“…The only serum marker test studied in human subjects is interleukin (IL)-6, which was found to be elevated in ovarian torsion [3]. In our previous experimental studies (in animals), we also showed that serum ischemia-modified albumin (IMA) and D -dimer may be used in the early diagnosis of ovarian torsion [4,5]. Since these studies were experimental, the role of IMA in the diagnosis of ovarian torsion in humans and the threshold value of IMA have not been known or previously reported.…”

Section: Introductionmentioning

confidence: 99%

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Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

Güven

Kart²,

Güven³

et al. 2015

Gynecol Obstet Invest

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Aim: The aim of this study is to evaluate the diagnostic value of serum oxidative stress marker levels (ischemia-modified albumin, IMA; malondialdehyde, MDA) and total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) levels that occur in ovarian torsion and to determine the threshold value of these markers in the diagnosis of ovarian torsion. Methods: In this prospective case-control study, 34 women (the study group) with acute pelvic pain (20 with and 14 without ovarian torsion) and 40 control subjects were included. The diagnosis of ovarian torsion was confirmed with laparoscopy in all cases. Preoperative serum samples were collected in the study group. Serum oxidative stress marker levels (IMA and MDA) and TOS, TAS and OSI levels were measured. Results: Serum MDA, TOS and IMA concentrations were significantly higher in women with ovarian torsion than in the healthy control group. However, serum TAS, TOS and OSI concentrations were significantly higher in women without ovarian torsion than within the healthy control group. Only IMA significantly distinguished patients with or without ovarian torsion. The best IMA value, according to the receiver operating characteristic curve, was 0.7045 absorbance units, with 90.00% sensitivity and 92.31% specificity. The patients in the ovarian torsion group had significantly lower serum TAS and OSI levels compared with patients without ovarian torsion. Conclusion: The elevated serum IMA levels with high sensitivity-specificity values observed in women with ovarian torsion seem to have a potential role as a serum marker in the preoperative diagnosis of ovarian torsion in emergency settings.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

Güven

Kart²,

Güven³

et al. 2015

Gynecol Obstet Invest

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“…IMA in rats, although suggested not to be equal to the human counterpart, has been reported to be useful in various studies (24, 25). In previous rat models, IMA was reported not to be signifi cant in acute mesentery ischemia, but it has been suggested that it could be used in ovarian torsion and renal ischemic damage as a non-selective biomarker (26)(27)(28). IMA has been demonstrated to be increased in cerebral ischemia (18).…”

Section: Discussionmentioning

confidence: 99%

Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death

Kara¹,

Pampal²,

Yıldırım³

et al. 2017

BLL

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AIM: Increased intracranial pressure following trauma and subsequent possible development of brain death are important factors for morbidity and mortality due to ischemic changes. We aimed to establish the role of ischemic modifi ed albumin (IMA) in the early diagnosis of the process, starting with increased intracranial pressure and ending with brain death. MATERIALS AND METHODS: Eighteen Wistar-Albino rats were divided into three groups; control (CG, n = 6), increased intracranial pressure (ICPG, n = 6), and brain death (BDG, n = 6). Intracranial pressure elevation and brain death were constituted with the infl ation of a balloon of a Fogarty catheter in the epidural space. In all three groups, blood samples were drawn before the procedure, and at minutes 150 and 240 for IMA and malondialdehyde (MDA) analysis. RESULTS: Serum IMA levels at 150 and 240 minutes were higher in ICPG than in CG (p < 0.05). IMA levels were similar in ICPG and BDG. Serum MDA levels at 150 and 240 minutes increased in ICPG and BDG groups compared to CG (p < 0.05). MDA levels were similar in ICP and BD groups. CONCLUSION: IMA should be considered as a biochemical parameter in the process starting from increased intracranial pressure elevation and ending at brain death (Tab. 3, Fig. 5, Ref. 31). Text in PDF www.elis.sk. KEY WORDS: ischemic modifi ed albumin, increased intracranial pressure, brain death.

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High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

Bakacak

Köstü

Ercan

et al. 2014

Arch Gynecol Obstet

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Serum ischemia-modified albumin as a novel marker of ovarian torsion: An experimental study

Cited by 24 publications

References 17 publications

Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death

High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

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