Acute appendicitis (AA) is not uncommon during pregnancy but can be difficult to diagnose. This study evaluated the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in addition to conventional diagnostic indicators of the disease to diagnose AA during pregnancy. Age, gestational age, white blood cell (WBC) count, Alvarado scores, C-reactive protein (CRP), lymphocyte count, NLR and PLR were compared among 28 pregnant women who underwent surgery for AA, 35 pregnant women wrongly suspected as having AA, 29 healthy pregnant women, and 30 nonpregnant healthy women. Mean WBC counts and CRP levels were higher in women with proven AA than in those of control groups (all p < 0.05). Among all the groups, the median NLR and PLR were significantly different in women with proven AA (all p < 0.05). Receiver operating characteristic analysis was used to determine cut-off values for WBC count, CRP, lymphocyte count, NLR and PLR, and multiple logistic regression analysis showed that NLR and PLR used with routine methods could diagnose AA with 90.5% accuracy. Used in addition to routine diagnostic methods, NLR and PLR increased the accuracy of the diagnosis of AA in pregnant women.

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Background/Aims: Ovarian torsion is a common cause of local ischemic damage, reduced follicular activity and infertility. Platelet-rich plasma (PRP) contains growth factors with demonstrated cytoprotective properties; so we evaluated PRP efficacy in a rat ischemia/reperfusion (I/R) model. Methods: Sixty adult female Sprague-Dawley albino rats were randomly assigned to 6 groups of 8 animals each: Sham, Ischemia, I/R, Sham + PRP, I + PRP and I/R + PRP; and the remaining 12 used to prepare PRP. Ischemia groups were subjected to bilateral adnexal torsion for 3 h, while I/R and I/R + PRP groups received subsequent detorsion for 3 h. Intraperitoneal PRP was administered 30 min prior to ischemia (Ischemia + PRP) or reperfusion (I/R + PRP). Results: Total oxidant status (TOS), oxidative stress index (OSI) and total ovarian histopathological scores were higher in Ischemia and I/R groups than in the Sham group (p < 0.05). PRP decreased mean TOS, OSI and histopathological scores in I + PRP and I/R + PRP groups compared to the corresponding Ischemia and I/R groups (p < 0.001). There was a strong correlation between total histopathological score and OSI (r = 0.877, p < 0.001). Peritoneal vascular endothelial growth factor was significantly higher in PRP-treated groups than corresponding untreated groups (p < 0.05). Conclusion: PRP is effective for the prevention of ischemia and reperfusion damage in rat ovary.

No abstract

Objectives: The present study aims to investigate the role of oxidant-antioxidant status in young women with polycystic ovary syndrome (PCOS). Material and methods:Seventy-one women with PCOS and 53 healthy controls are compared in aspect of demographic characteristics, biochemical data, hormones, and oxidant-antioxidant status. Results:The PCOS group had significantly lower zinc, higher malondialdehyde and gluthathione peroxidase and lower serum catalase levels than the control group (p = 0.016, p < 0.001, p = 0.043 and p = 0.025 respectively). The PCOS patients with IR had significantly higher malondialdehyde, lower catalase and serum zinc levels than the PCOS patients without IR (p = 0.015, p = 0.010, p = 0.001 respectively). The infertile PCOS patients had significantly higher malondialdehyde, lower catalase and serum zinc levels than the fertile PCOS patients Conclusions:The patients with PCOS are under oxidative stress and this oxidative stress seems to be the highest in patients with IR and with infertility. Despite the prominent increase in the oxidative stress, there was a variation in the antioxidant response.

Low hemoglobin concentrations in the first trimester of gestation seem to be associated with low fetal birth weights. Anemia can directly cause poor in utero fetal growth due to inadequate oxygen flow to the placental tissue or it can be an indirect indicator of maternal nutrition deficiency. In both circumstances, this study reveals that treatment of anemia before and in the early stages of pregnancy is directly correlated with better fetal outcomes.

Amaç: Gebelerde, rubella ve sitomegalovirüsun (CMV) yapmış olduğu primer infeksiyon fetusta ciddi sorunlara yol açar. Çalışmamızda, Ege Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Seroloji Laboratuvarı'na Kadın Hastalıkları ve Doğum polikliniğinden gönderilen gebelerde rubella ve CMV seropozitifliğinin geriye dönük araştırılması amaçlandı. Gereç ve Yöntem: Ocak 2011 ve Aralık 2011 tarihleri arasında Ege Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Seroloji Laboratuvarına gönderilen yaşları 14-57 arasında (ortalama 29.5) 1875 gebenin serum örneklerinde rubella IgG ve IgM antikorları ve yine aynı tarihlerde gelen, yaşları 17-45 arasında (ortalama 29) olan 1847 gebenin CMV IgG ve IgM antikorları araştırıldı. Serum örnekleri ticari otomatize sistem ile test edildi. Bulgular: 1875 gebenin 1744'ünde (%93,2) rubella IgG pozitifliği, 3'ünde (%0,2) rubella IgM pozitifliği saptandı. 1847 gebenin 1339'ında (%99) CMV IgG pozitifliği, 25'inde (%1,4) CMV IgM pozitifliği saptandı. Rubella açısından bakıldığında yaş arttıkça serum IgG düzeyinde istatiksel olarak anlamlı bir azalma olduğu görüldü (p=0.006). Sonuç: Gebelikte primer infeksiyon geçirilmesi ile ortaya çıkabilecek sorunlar düşünüldüğünde rubella infeksiyonu açısından aşılamanın ve CMV açısından gebelik öncesi immünite durumunun belirlenmesi ve gebelik döneminde CMV bulaşının önlenmesi konusunda gebenin bilgilendirilmesinin önemi ortaya çıkmaktadır. Anahtar Sözcükler: Sitomegalovirüs, gebe, rubella. Summary Aim: Primary infections caused by rubella and cytomegalovirus (CMV) can lead to serious complications in pregnancy. The purpose of this study was to determine seroprevalences of the rubella virus and CMV retrospectively, from samples from pregnant women which were sent to pregnant women (age range 14-57, mean 29.5 years) were screened for rubella antibodies and 1847 pregnant women (age range 17-45, mean 29 years) were screened for CMV antibodies. Serum samples were tested by the automated commercial ELISA system. Results: Rubella IgG seropositivity was detected in 1744 (93.2%) and rubella IgM was detected in 3 (0.2%) of the 1875 pregnant women. For CMV, IgG seropositivity was found in1339 (99%) and CMV IgM in 25 (1.4%) of the 1847 pregnant women. A statistically significant reduction in rubella IgG levels with an increase in age was recorded (p=0.006). Conclusion: The problems that can be caused by primary CMV and rubella infections during pregnancy are serious. For prevention of rubella infections, vaccination programs should be carried out carefully. For CMV infection prevention in pregnancy, determination of the status of CMV immunity before pregnancy and informing pregnant women about preventive measures for transmission of CMV are extremely important.

The ACOG has recently revised the grading of hypertensive diseases of pregnancy and the criteria for severe preeclampsia. In line with these revised guidelines, serum NT-proBNP levels appear to be a useful marker to evaluate the severity of preeclampsia.