Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients

Bedogni, Giorgio; Giannone, Germana; Maghnie, Mohamad; Giacomozzi, Claudia; Iorgi, Natascia Di; Pedicelli, Stefania; Peschiaroli, Emanuela; Melioli, Giovanni; Muraca, Maurizio; Cappa, Marco; Cianfarani, Stefano

doi:10.1016/j.ghir.2012.04.005

Cited by 32 publications

(26 citation statements)

References 28 publications

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“…Age is the most important factor contributing to IGF-1 variation. An Italian report [13] studied the inpatient and outpatient children aged 0 to 18 and the peak IGF-1 was 15 years old, which was in accordance with the Elmlinger's data [5]. Alice P.S.…”

Section: Statisticssupporting

confidence: 79%

Serum Insulin-like growth factor-1 levels of healthy adults in southern China

Yin

Wan

et al. 2016

Endocr J

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Section: Statisticssupporting

confidence: 79%

Serum Insulin-like growth factor-1 levels of healthy adults in southern China

Yin

Wan

et al. 2016

Endocr J

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“…In this way we may compare our results at the same GH threshold of 10 g/l before and after the introduction of the new method of analysis. IGF-1 was measured by different assays in different years (Nichols Advantage, San Juan Capistrano, Calif., USA, from 2003 to 2009 and Immulite 2000, Siemens, from 2010 to 2012) and expressed as raw value in micrograms per liter and SDS according to reference range [24]. The sensitivity limit of the assays were 6 and 20 µg/l, respectively; the intra- and interassay coefficients of variation were 4.8 and 6.7%, and 2.3-3.9 and 8.6-10.1%, respectively, for the two methods used in our laboratory in different years.…”

Section: Methodsmentioning

confidence: 99%

Growth Hormone Response to Standard Provocative Stimuli and Combined Tests in Very Young Children with Prader-Willi Syndrome

et al. 2014

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Background: In Prader-Willi syndrome (PWS) a reduced growth hormone (GH) response to several stimulators has been documented in many studies, but none have focused on very young children. We evaluated the pattern of GH secretion in very young PWS patients. Patients and Methods: Twenty-seven genetically confirmed PWS children (10 females, aged 0.4-5 years, mean: 2.2 ± 1.4 years) were included. All subjects underwent standard provocative tests (clonidine, CLO; and arginine, ARG) and one combined test [growth hormone-releasing hormone (GHRH) plus pyridostigmine (13 patients) or GHRH plus arginine (14 patients)]. Insulin-like growth factor-1 (IGF-1) levels were also measured. Results: While standard tests (CLO and ARG) showed low GH peak in 85.2 and 70.4% of the patients, respectively, the combined test was found to be normal in 85.2%. IGF-1 was low in 66.7% of patients. Out of 27 patients, 3 (11%) showed a normal GH peak with both standard tests (group A), 6 (22%) to one of the standard tests (group B) and 18 (67%) presented a low response to both standard tests (group C). Four subjects showed low response to both the combined and standard tests and reduced IGF-1. Conclusion: Our data suggest that very young PWS children seem to have impaired hypothalamic GHRH secretion with a normal GH pituitary reserve.

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“…Bedogni et al 17 found that IGF-1 concentrations rose with increasing age in their cross-sectional study of 24,403 subjects 0 -18 y old. Conversely, IGF-1 and IGFBP-3 concentrations decreased following surgery in our study as the children aged (after making adjustments for time after surgery, disease duration, AHI, time spent at S pO 2 Ͻ 90%, and BMI Z score).…”

Section: Discussionmentioning

confidence: 94%

Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Children With Obstructive Sleep Apnea-Hypopnea Syndrome

Zhu¹,

Fang²,

Wang

et al. 2014

Respir Care

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BACKGROUND: The aim of this study was to assess insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) concentrations in children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to compare the results according to disease severity and duration. METHODS: Fifty-one children with OSAHS underwent polysomnography and were classified as having mild, moderate, or severe disease. All children underwent bilateral tonsillectomy/adenoidectomy or adenoidectomy. IGF-1 and IGFBP-3 concentrations were assessed before surgery and 3 and 6 months after surgery. RESULTS: Before surgery, IGF-1 and IGFBP-3 concentrations were significantly higher (P < .

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Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients

Cited by 32 publications

References 28 publications

Serum Insulin-like growth factor-1 levels of healthy adults in southern China

Serum Insulin-like growth factor-1 levels of healthy adults in southern China

Growth Hormone Response to Standard Provocative Stimuli and Combined Tests in Very Young Children with Prader-Willi Syndrome

Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Children With Obstructive Sleep Apnea-Hypopnea Syndrome

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