Serum Insulin-like growth factor-1 levels of healthy adults in southern China

Li, Zhihong; Yin, Qi-Qi; Wan, Jianxin; He, Wei; Ji, Wen; Zhang, Luyao; Li, Yanbing

doi:10.1507/endocrj.ej16-0144

Cited by 3 publications

(2 citation statements)

References 14 publications

(25 reference statements)

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“…In addition to age, sex and physiological condition, the serum IGF-I levels also vary with ethnicity [ 7 , 8 ]. Liao et al recently published reference IGF-I levels in a population from South China [ 9 ]. However, the number of adults between 18–20 years of age and the number of enrolled subjects were limited.…”

Section: Introductionmentioning

confidence: 99%

Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

Zhu

Gong

et al. 2017

PLoS ONE

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PurposeTo determine serum insulin-like growth factor 1 (IGF-I) levels in healthy Chinese adults, establish reference ranges for serum IGF-I levels and observe the effects of age, sex, body mass index (BMI) and geographical region on serum IGF-I levels.MethodsIn total, 2791 healthy adults (1339 males and 1452 females) from the north (Beijing) and south (Guizhou Province) of China were recruited following a questionnaire survey, physical examination and laboratory examination. Both sexes were divided into 13 groups according to age (18, 19, 20–24, 25–29, 30–34, 35–39, 40–44, 45–49, 50–54, 55–59, 60–64, 65–69 and ≥70 years). The serum IGF-I levels were measured by performing a chemiluminescent assay (Immulite 2000®), and the LMS (Lambda-Mu-Sigma) method was applied to construct smooth centile curves of age-specific IGF-I levels.ResultsSerum IGF-I levels in the adults gradually decreased with increasing age from 18 to 70 years in both the male and female participants. Although the decrease in the level of IGF-1 was more pronounced in females than in males, no significant difference was observed between the sexes, except in the 60- to 64-year-old age group (P = 0.0329). The multiple linear regression model showed that there was an inverse relationship between the serum IGF-I level and BMI (P<0.001), and the serum IGF-I level in the Guizhou population was higher than that in the Beijing population (P<0.05).ConclusionThe normal reference ranges for age- and sex-specific serum IGF-I levels were established for the first time in a large sample of Chinese adults. The serum IGF-I levels were significantly influenced by age, BMI and geographical region.

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Section: Introductionmentioning

confidence: 99%

Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

Zhu

Gong

et al. 2017

PLoS ONE

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“…However, we could not determine the correct distributions of individuals aged >80 years because of the limited number of cases. Studies have reported the progressive decrease in serum IGF-1 concentrations before reaching a plateau in older ages [1,7,[14][15][16], although the exact age for reaching a plateau is unknown. For example, Bidlingmaier et al reported the median serum IGF-1 concentrations of males and females aged 81-85 and 86-90 years, i.e., 86.1 and 85.0 ng/mL, and 89.1 and 90.3 ng/mL, respectively, presenting that their progressive decline reached a plateau at approximately the age of 80 years [1].…”

Section: Discussionmentioning

confidence: 99%

Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations

Isojima,

Shimatsu

2023

Endocr J

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Measurements of serum insulin-like growth factor 1 (IGF-1) levels are useful surrogate markers for the diagnosis and management of patients with growth hormone-related disorders. We have previously published normative data of serum IGF-1 levels for the Japanese population aged 0-77 years by combining and analyzing previously reported references, which were separately and independently constructed, to properly reflect data in the transition period. Although the reference is widely used in both clinical and research settings, the reference did not include data for those aged >77 years, raising the question of how we would evaluate patients over those ages. In this study, we extended the age-and sex-specific reference ranges of serum IGF-1 levels to the age of 80 years by reanalyzing combined data on serum IGF-1 levels from previously published references. Based on our results, we proposed that individuals aged >80 years can be evaluated using the references set at the age of 80 years. However, our proposal was based on a very limited number of participants. Therefore, physicians should exercise caution when interpreting IGF-1 standard deviation scores for those aged >80 years because they are not exactly correct but acceptable.

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The Effects of Biological Sex and Ovarian Hormones on Exercise-Induced Neuroplasticity

et al. 2019

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Serum Insulin-like growth factor-1 levels of healthy adults in southern China

Cited by 3 publications

References 14 publications

Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations

The Effects of Biological Sex and Ovarian Hormones on Exercise-Induced Neuroplasticity

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