Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

Zhu, Huijuan; Xu, Yuan; Gong, Fengying; Shan, Guangliang; Yang, Hongbo; Xu, Ke; Zhang, Dianxi; Cheng, Xinqi; Zhang, Zhihao; Chen, Shi; Wang, Linjie; Pan, Hui

doi:10.1371/journal.pone.0185561

Cited by 60 publications

(55 citation statements)

References 44 publications

(49 reference statements)

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“…ER was defined as a random GH<1.0 ng/ml or a GH nadir<0.4 and age-gender normalized IGF-1 (27). The IGF-1 reference range used in this study referred to our published article (28). Repeated surgery, octreotide LAR treatment and observation were recommended for recurrent patients according to the radiological findings and hormone levels.…”

Section: Study Design and Follow-upmentioning

confidence: 99%

Reversibility of Cardiac Involvement in Acromegaly Patients After Surgery: 12-Month Follow-up Using Cardiovascular Magnetic Resonance

Guo

Cao

et al. 2020

Front. Endocrinol.

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Purpose: Cardiac comorbidity is one of the leading causes of death among acromegaly patients. We aimed to investigate the reversibility of acromegalic cardiac involvement after surgical treatment using the gold standard method, cardiovascular magnetic resonance, and to explore the effects of endocrine remission and gender on reversibility. Methods: In this single-center, prospective cohort study, fifty untreated acromegaly patients were enrolled. Comprehensive cardiac assessments were performed using a 3.0 T magnetic resonance scanner before and 3 and 12 months after transsphenoidal adenomectomy. Results: Preoperatively, left ventricular (LV) enlargement (13.0%), LV systolic dysfunction (6.5%), right ventricular (RV) enlargement (4.3%), RV systolic dysfunction (2.2%) and myocardial fibrosis (12.0%) were identified. On average, the LV and RV ejection fractions of acromegaly patients were higher than the healthy reference values. Male patients had thicker LV myocardia, wider ventricular diameters and more dilated pulmonary artery roots than female patients. After surgery, LV myocardial hypertrophy was reversed, the left atrium was remodeled, and ventricular systolic dysfunction recovered to normal. Cardiac alterations were detected early in the 3 rd postoperative month and persisted until the 12 th month. The interventricular septum was initially thickened in the 3 rd postoperative month and then recovered at the 12th month. Notable postoperative cardiac reversibility was observed in male patients but did not occur in all female patients. Patients achieving endocrine remission with normalized hormone levels had thinner LV myocardia than patients without normalized hormone levels. Conclusion: Our findings demonstrated that some of the cardiac involvement in acromegaly patients is reversible after surgical treatment which lowers hormone levels. Endocrine remission and gender significantly impacted postoperative cardiac reversibility.

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Section: Study Design and Follow-upmentioning

confidence: 99%

Reversibility of Cardiac Involvement in Acromegaly Patients After Surgery: 12-Month Follow-up Using Cardiovascular Magnetic Resonance

Guo

Cao

et al. 2020

Front. Endocrinol.

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“… 9 , 19 - 21 IGF1 concentration decreased with increasing age, with no obvious additional decline after approximately 50 years of age. 22 – 24 Thus, it has been speculated that the inverse association between IGF1 and age might be the key determinant of the varied association patterns by menopausal status. 9 Age at menarche is an indicator of puberty development and has also been associated with higher concentrations of IGF1.…”

Section: Discussionmentioning

confidence: 99%

<p>Biomarkers of Insulin and the Insulin-Like Growth Factor Axis in Relation to Breast Cancer Risk in Chinese Women</p>

Zhu¹,

Wang²,

Wu³

et al. 2020

OTT

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Background: The interplay between biomarkers of insulin and the insulin-like growth factor (IGF) axis in the context of breast cancer risk is unclear. Methods: We measured the concentrations of insulin, C-peptide, IGF1, and IGF binding protein 3 (IGFBP3) and calculated the homeostasis model assessment of insulin resistance (HOMA-IR) index and the IGF1/IGFBP3 ratio among 2536 patients with breast cancer and 2528 patients with benign breast disease recruited from Ruijin Hospital, Shanghai, China, between 2012 and 2017. Results: Multivariable-adjusted odds ratios (ORs) for breast cancer associated with the highest quartiles versus the lowest quartiles of insulin and IGF factors were 1.45 (95% CI, 1.20-1.75) for insulin, 1.32 (1.08-1.60) for C-peptide, 1.53 (1.26-1.85) for HOMA-IR, and 1.27 (1.05-1.53) for IGF1; these associations did not differ substantially across stratifications of age, body mass index, age at menarche, or menopausal status (all P for interaction >0.05). In the joint analysis, the highest quartile of IGF1 was associated with the greatest risk of breast cancer in the highest quartiles of insulin (OR, 1.77; 95% CI, 1.29-2.44), C-peptide (1.60; 1.17-2.20), and HOMA-IR (1.90; 1.38-2.62), compared with the risks associated with the combination of the lowest quartiles of IGF1 and each insulin factor. In stratification analysis, the positive association between IGF1 and breast cancer was stronger in the highest quartiles of insulin (P[interaction] = 0.29), C-peptide (P[interaction] = 0.020), and HOMA-IR (P[interaction] = 0.075). Conclusion: Our findings indicate effect modifications of insulin, C-peptide, and insulin resistance on the relationship between IGF1 and breast cancer risk in Chinese women.

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“…The most likely reason for this difference is the use of different assay kits in the measurement of serum IGF-1 levels between the two studies. Previous studies have reported significant differences in serum IGF-1 levels when using different assay kits, even though the samples were from the same population [28][29][30] . Different assay kits have different age-and sex-specific reference ranges, and this might affect the upper and lower limit of each study's serum IGF-1 levels.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Relationship between Serum IGF-1 and BMI by Age in the Long Life Family Study

Sherlala

Kammerer

Kuipers

et al. 2020

Preprint

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Background: Serum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies. Methods: Using data on 4,241 participants (aged 24-110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis. Results: When stratified by age quartile, the correlation between IGF-1 and BMI varied: in the 1st quartile (Q1, 24 y-58 y) the correlation was negative (r = −0.1, P = 0.0008); in Q2 (59 y-66 y) it was negative (r = −0.035) but non-significant; in Q3 (67 y-86 y) it was positive (r = 0.045) but non-significant; and in Q4 (87 y-110 y) the correlation was positive (r = 0.14, P < 0.0001). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey. Conclusions: Our results, that the relationship between IGF-1 and BMI differs by age, may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.

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Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

Cited by 60 publications

References 44 publications

Reversibility of Cardiac Involvement in Acromegaly Patients After Surgery: 12-Month Follow-up Using Cardiovascular Magnetic Resonance

Reversibility of Cardiac Involvement in Acromegaly Patients After Surgery: 12-Month Follow-up Using Cardiovascular Magnetic Resonance

<p>Biomarkers of Insulin and the Insulin-Like Growth Factor Axis in Relation to Breast Cancer Risk in Chinese Women</p>

Assessing the Relationship between Serum IGF-1 and BMI by Age in the Long Life Family Study

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