Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Children With Obstructive Sleep Apnea-Hypopnea Syndrome

Zhu, Jihe; Fang, Yu; Wang, Haifei; Chen, Xin; Yu, Daojun; Shen, Yi

doi:10.4187/respcare.03516

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…Zhu et al evaluated the role of adenoidectomy and/or tonsillectomy on insulin-like growth factor 1 levels in children with OSA. 8 The authors found a significant increase in insulin-like growth factor 1 levels post-surgery in these children.…”

Section: Introductionmentioning

confidence: 84%

Effect of surgical intervention on serum insulin-like growth factor 1 in patients with obstructive sleep apnoea

Jaiswal¹,

Valappil²,

Gupta³

et al. 2023

J. Laryngol. Otol.

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Objective. To evaluate the effect of surgical intervention on serum insulin-like growth factor 1 levels in patients with obstructive sleep apnoea. Methods. A prospective study was conducted in a tertiary care hospital of adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy failed or was refused. All patients underwent polysomnography and serum insulin-like growth factor 1 evaluation pre-operatively and at three months post-operatively. The site of surgery was determined using Müller's manoeuvre and ApneaGraph AG 200. Results. Fifteen patients were included with a mean age of 38 years: 11 males and 4 females. The mean pre-operative Apnoea-Hypopnoea Index using polysomnography was 53.7 events per hour, and the mean post-operative Apnoea-Hypopnoea Index at three months was 15.3 events per hour ( p = 0.0001). The mean pre-operative serum insulin-like growth factor 1 was 160.2 μg/l, while the mean post-operative value was 236.98 μg/l ( p = 0.005). Conclusion.In adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy fails, site-specific surgical intervention to treat the obstruction leads to an increase in serum insulin-like growth factor 1 levels.

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Section: Introductionmentioning

confidence: 84%

Effect of surgical intervention on serum insulin-like growth factor 1 in patients with obstructive sleep apnoea

Jaiswal¹,

Valappil²,

Gupta³

et al. 2023

J. Laryngol. Otol.

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“…Pediatric OSA may occasionally lead to life-threatening complications, but less serious complications, such as failure to thrive, are more commonly recognized. 11 To explain this latter observation, it has recently been reported that serum levels of IGF-1 in children with OSA are increased after surgery, including tonsillectomy and adenotonsillectomy, [12][13][14] and when they are treated using continuous positive airway pressure (CPAP). 15 This finding highlights the association between OSA and reduced levels of IGF-1.…”

Section: Introductionmentioning

confidence: 99%

Serum concentrations of insulin-like growth factor-1 as a biomarker of improved circadian rhythm sleep-wake disorder in school-aged children

Kimura

Toyoura²,

Toyota³

et al. 2020

Journal of Clinical Sleep Medicine

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Study Objectives: We aimed to investigate whether improvements in the symptoms of circadian rhythm sleep-wake disorder after treatment were associated with an increase in serum insulin-like growth factor-1 (IGF-1) concentration. Methods: Eighty-seven school-aged children (32 males, 55 females), aged 14.31 ± 1.50 years (mean ± standard deviation), who were admitted to our hospital with circadian rhythm sleep-wake disorder received treatment for 6-8 weeks consisting of the following protocol: (1) lights-out for sleep occurred at 21:00, (2) phototherapy for waking started at 06:00 or 07:00, and (3) light exercise was required every day (eg, a 20-to 30-minute walk). Blood samples were collected at 08:00 AM to measure the serum concentrations of IGF-1, pre-and posttreatment. Results: The mean times of day of sleep onset and offset at the pre-and posttreatment timepoints were 23:32 ± 4.21 and 10:27 ± 2.98, and 21:26 ± 0.55 and 06:50 ± 0.70, respectively. The mean times of day of sleep onset and offset measured at the posttreatment timepoint were significantly earlier compared with the pretreatment baselines (P <.01). The mean serum levels of IGF-1 significantly increased from 315.59 ± 68.26 ng/mL at pretreatment to 335.09 ± 69.78 ng/mL at posttreatment (P < .01). Conclusions: Improvements in the symptoms of patients with circadian rhythm sleep-wake disorders were associated with increased serum concentrations of IGF-1, suggesting that serum IGF-1 may be a biomarker of improvements in school-aged children with circadian rhythm sleep-wake disorder.

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“…Inflammation, infection, and allergic stimulation of follicles of these lymphoid tissues usually result in their cellular hyperplasia and enlargement, thus causing varied degrees of pharyngeal airway obstruction [4,5]. The symptoms of obstruction caused by the enlarged lymphoid tissues result not only from their actual size, but also from their relative disproportional size to nasopharyngeal and/or oropharyngeal airway space [6,7].…”

Section: Introductionmentioning

confidence: 99%

Short-term effect of adenotonsillectomy on growth and nutritional anthropometric parameters of children with obstructive adenotonsillar enlargement

Fasunla

Totyen

Onakoya

et al. 2020

Egypt Pediatric Association Gaz

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Background: Obstructive adenotonsillar enlargement is known to cause failure to thrive in children. The effect of adenotonsillectomy is not well documented on the growth of affected children. The study was carried out to investigate the effect of adenotonsillectomy on growth of children with obstructive adenotonsillar enlargement. It was a quasi-experimental study consisting of 62 children (≤ 12 years) with obstructive adenotonsillar enlargement and 62 healthy controls. Variables measured at baseline, sixth week and 13th week post adenotonsillectomy, were weight, height, mid-upper arm circumference, and triceps skinfold thickness. The percent of weight-forage and height-forage were, respectively, calculated by dividing the child's weight and height by the median expected weight and height (i.e., the 50th percentile) based on the child's chronological age. The obtained weight-forage and height-forage values were used to determine the presence of failure to thrive and stunting, respectively. Results: Majority (70.6%) of the patients with malnutrition were from a low socioeconomic class. At baseline, failure to thrive and stunting were found among 17 (26.4%) cases and 11 (17.7%) controls, but the proportion reduced to six (9.7%) and three (4.8%), respectively, at the 13th week post adenotonsillectomy. There was a steady increase in weight-forage , height-forage , mid-upper arm circumference, and triceps skinfold thickness in both cases and controls from baseline to the 13th week. However, there was a significant difference in percentage variation of these variables between the two groups. Conclusions: Adenotonsillectomy improved the growth of children with obstructive adenotonsillar enlargement and hence recommended in cases with failure to thrive and stunting.

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Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Children With Obstructive Sleep Apnea-Hypopnea Syndrome

Cited by 8 publications

References 16 publications

Effect of surgical intervention on serum insulin-like growth factor 1 in patients with obstructive sleep apnoea

Effect of surgical intervention on serum insulin-like growth factor 1 in patients with obstructive sleep apnoea

Serum concentrations of insulin-like growth factor-1 as a biomarker of improved circadian rhythm sleep-wake disorder in school-aged children

Short-term effect of adenotonsillectomy on growth and nutritional anthropometric parameters of children with obstructive adenotonsillar enlargement

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