Serum concentrations of insulin-like growth factor-1 as a biomarker of improved circadian rhythm sleep-wake disorder in school-aged children

Abstract

Study Objectives: We aimed to investigate whether improvements in the symptoms of circadian rhythm sleep-wake disorder after treatment were associated with an increase in serum insulin-like growth factor-1 (IGF-1) concentration. Methods: Eighty-seven school-aged children (32 males, 55 females), aged 14.31 ± 1.50 years (mean ± standard deviation), who were admitted to our hospital with circadian rhythm sleep-wake disorder received treatment for 6-8 weeks consisting of the following protocol: (1) lights-out for sleep occurred at 21:00, (2) phototherapy for waking started at 06:00 or 07:00, and (3) light exercise was required every day (eg, a 20-to 30-minute walk). Blood samples were collected at 08:00 AM to measure the serum concentrations of IGF-1, pre-and posttreatment. Results: The mean times of day of sleep onset and offset at the pre-and posttreatment timepoints were 23:32 ± 4.21 and 10:27 ± 2.98, and 21:26 ± 0.55 and 06:50 ± 0.70, respectively. The mean times of day of sleep onset and offset measured at the posttreatment timepoint were significantly earlier compared with the pretreatment baselines (P <.01). The mean serum levels of IGF-1 significantly increased from 315.59 ± 68.26 ng/mL at pretreatment to 335.09 ± 69.78 ng/mL at posttreatment (P < .01). Conclusions: Improvements in the symptoms of patients with circadian rhythm sleep-wake disorders were associated with increased serum concentrations of IGF-1, suggesting that serum IGF-1 may be a biomarker of improvements in school-aged children with circadian rhythm sleep-wake disorder.

Lower serum insulin-like growth factor 1 concentrations in patients with chronic insomnia disorder

“…Chennaoui et al also discovered that the IGF-1 system responds to sleep deprivation, with serum IGF-1 concentrations decreasing after 25 h of sleep deprivation and increasing again after a night of recovery (7). Kimura et al reported that decreases in the symptoms of patients with circadian rhythm sleep-wake disorders were associated with increased serum concentrations of IGF-1 (22). Although the results differ among those studies, they all suggest that sleep deprivation is related to IGF-1.…”

Adult Neurogenesis under Control of the Circadian System

“…Plasma IGF-1 levels reveal a pronounced 24 h rhythm in rats with a peak level at the end of the dark phase and beginning of the light phase [ 113 ]. Inflammatory conditions could impair the IGF-1 rhythms [ 113 ], while improved circadian rhythm sleep–wake disorder is associated with increase in IGF-1 level [ 114 ]. Interestingly, melatonin is implicated in IGF-1 regulation via multiple pathways involved in the energy metabolism, e.g., PI3K–Akt signaling and glycogen synthase kinase 3 β (GSK3β) [reviewed in [ 100 ]].…”

New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress

“…The IIS pathway plays a vital role in sleep regulation. In the treatment of patients with circadian rhythm sleep-wake disorders, improvements in symptoms were found to be strongly associated with increased serum concentrations of insulin-like growth factor (IGF-1) [ 190 ]. In-depth studies have found that the activity of orexin neurons is modulated by IGF-1, which controls sleep duration and architecture [ 191 ].…”