Adult Neurogenesis under Control of the Circadian System

Ali, Amira A. H.; Gall, Charlotte von

doi:10.3390/cells11050764

Cited by 28 publications

(22 citation statements)

References 213 publications

(296 reference statements)

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“…The cellular substrate for hippocampal learning and memory is neuroplasticity. Structural hippocampal plasticity is provided by changes in spine formation and by adult neurogenesis in the subgranular zone (SGZ) of the DG [ 127 , 128 , 129 ] which is strongly influenced by the circadian system [ 130 ]. We have shown that adult neurogenesis is affected in BMAL1-deficient mice [ 59 , 131 , 132 ].…”

Section: The Role Of Light and The Circadian Clock For Rhythmic Brain...mentioning

confidence: 99%

The Effects of Light and the Circadian System on Rhythmic Brain Function

Gall

2022

IJMS

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Life on earth has evolved under the influence of regularly recurring changes in the environment, such as the 24 h light/dark cycle. Consequently, organisms have developed endogenous clocks, generating 24 h (circadian) rhythms that serve to anticipate these rhythmic changes. In addition to these circadian rhythms, which persist in constant conditions and can be entrained to environmental rhythms, light drives rhythmic behavior and brain function, especially in nocturnal laboratory rodents. In recent decades, research has made great advances in the elucidation of the molecular circadian clockwork and circadian light perception. This review summarizes the role of light and the circadian clock in rhythmic brain function, with a focus on the complex interaction between the different components of the mammalian circadian system. Furthermore, chronodisruption as a consequence of light at night, genetic manipulation, and neurodegenerative diseases is briefly discussed.

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Section: The Role Of Light and The Circadian Clock For Rhythmic Brain...mentioning

confidence: 99%

The Effects of Light and the Circadian System on Rhythmic Brain Function

Gall

2022

IJMS

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“…Активность гиппокампа опосредует связь между циркадными ритмами и состоянием памяти Ali, von Gall, 2022). Успешное разделение паттернов эмоциональных воспоминаний связано с тета-диапазоном в гиппокампе, тогда как ошибочное различение эмоциональных стимулов сопровождается усилением мощности альфа-диапазона (Zheng et al, 2019).…”

Section: гиппокамп через призму функциональной нейровизуализацииunclassified

The Role of the Hippocampus in Detecting the Novelty of Impressions: A Literature Review

Kaverina¹,

Kuleva²,

Krotkova³

2022

RJCS

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The article presents a review of modern studies of the hippocampus’s functions in the implementation of cognitive phenomena, a review which covers a wide range of experimental areas, including high-precision brain morphometry, functional neuroimaging, electroencephalography, deep navigational electrode implantation, and dosed radiation effects on the brain. Literary sources demonstrate the involvement of the hippocampus in almost all spheres and aspects of human mental activity, from memory to eye movements, from circadian rhythms to spatial navigation. The literature review allows us to generalize the results of many works and to speak about the basic characteristic of the hippocampus’s functional activity in information processing: that the hippocampus is a comparator which continuously marks impressions of the current experience according to the degree of novelty. The authors see such a functional analysis as much more productive than attempts to correspond brain structures with mental processes (perception, memory, attention) and, accordingly, than the customary discussion in the scientific literature of the hippocampus functioning mainly as a brain substrate of memory

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“…Specifically, C3H mice with functional MT1/MT2 receptors show a time-of-day-dependent fluctuation in the number of proliferation neuronal stem/progenitor cells in contrast to the MT1/MT2 double KO mice ( Fredrich et al, 2017 ). Additional promoting effects of melatonin on adult neurogenesis such as antioxidative activity and enhanced expression of neurotrophic factors are suggested (reviewed in Ali and von Gall, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of the Melatoninergic System in Circadian and Seasonal Rhythms—Insights From Different Mouse Strains

et al. 2022

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The melatoninergic system comprises the neurohormone melatonin and its molecular targets. The major source of melatonin is the pineal organ where melatonin is rhythmically produced during darkness. In mammals, melatonin biosynthesis is controlled by the central circadian rhythm generator in the suprachiasmatic nucleus (SCN) and photoreceptors in the retina. Melatonin elicits its function principally through two specific receptors called MT1 and MT2. MT1 is highly expressed in the SCN and the hypophysial pars tuberalis (PT), an important interface for control of seasonal functions. The expression of the MT2 is more widespread. The role of the melatoninergic system in the control of seasonal functions, such as reproduction, has been known for more than 4 decades, but investigations on its impact on the circadian system under normal (entrained) conditions started 2 decades later by comparing mouse strains with a fully functional melatoninergic system with mouse strains which either produce insufficient amounts of melatonin or lack the melatonin receptors MT1 and MT2. These studies revealed that an intact melatoninergic system is not required for the generation or maintenance of rhythmic behavior under physiological entrained conditions. As shown by jet lag experiments, the melatoninergic system facilitated faster re-entrainment of locomotor activity accompanied by a more rapid adaptation of the molecular clock work in the SCN. This action depended on MT2. Further studies indicated that the endogenous melatoninergic system stabilizes the locomotor activity under entrained conditions. Notably, these effects of the endogenous melatoninergic system are subtle, suggesting that other signals such as corticosterone or temperature contribute to the synchronization of locomotor activity. Outdoor experiments lasting for a whole year indicate a seasonal plasticity of the chronotype which depends on the melatoninergic system. The comparison between mice with an intact or a compromised melatoninergic system also points toward an impact of this system on sleep, memory and metabolism.

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Adult Neurogenesis under Control of the Circadian System

Cited by 28 publications

References 213 publications

The Effects of Light and the Circadian System on Rhythmic Brain Function

The Effects of Light and the Circadian System on Rhythmic Brain Function

The Role of the Hippocampus in Detecting the Novelty of Impressions: A Literature Review

The Role of the Melatoninergic System in Circadian and Seasonal Rhythms—Insights From Different Mouse Strains

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