Serum immunoglobulins in psoriatic erythroderma

Abstract

The cause of psoriatic erythroderma (PE) is still unknown. Elevation of serum IgE has been reported in erythroderma, and as serum hyper-IgE is Th2 cell dominated it is of interest to investigate the serum IgE level in PE. In this study, the level of immunoglobulins in the sera of PE patients was analysed by a retrospective case-control study using psoriasis vulgaris (PV) patients as controls. The PE and PV patients were matched in a 1:3 pattern: the first three age and sex matched PV inpatients were selected. All of the subjects were nonatopic and without allergic history. The serum IgE level was found to be elevated in 81.3% of the PE group, which is much higher than that (6.3%) of the controls (odds ratio, 65.0; 95% CI, 11.7-361.2; P < 0.001; chi2 test). The mean level of serum IgE was much higher in the PE group (272.38 +/- 207.63 IU/mL vs. 53.20 +/- 86.05 IU/mL, P < 0.001, Student's t-test). No differences were found for other immunoglobulins. These results suggest that in PE the Th1/Th2 cell imbalance may be switched from Th1 dominant to Th2 dominant. The exact role of serum IgE in PE should be investigated further.

High Serum IgE Concentration in Patients with Psoriasis

“…Moreover, we demonstrated that all types of psoriasis had significantly increased serum IgE levels compared to the controls. In agreement with our data, a case-control study showed that the mean level of serum IgE in PE patients was much higher than that in PV patients and they suggested that a shift from Th1 to Th2 occurred in PE [10]. The IgE levels were also higher in PsA patients in our study, but the difference between PsA and PV was not statistically significant.…”

“…The result is consistent with some studies [7][8][9][10][11]. Yan et al demonstrated that 39% of patients with psoriasis had elevated serum IgE concentrations and they observed that lesional skin of patients with psoriasis contains more IgE+ and FceRI+ cells [20].…”

“…There is some evidence that IgE may take a part in the pathogenesis of psoriasis. Some studies found increased levels of serum IgE in psoriasis patients while other studies showed that the serum IgE levels in patients with psoriasis are no different to that of the normal controls [7][8][9][10][11][12][13]. The purpose of our study was to measure the expression of serum IgE in patients with psoriasis and normal subjects, and to analyze its association with sex, age, duration, types of psoriasis and some circulating cytokines.…”

Analysis of selected allergic reactions among psoriatic patients

“…psoriatic erythroderma. Li's research showed the serum IgE level was found to be elevated in 81.3% of patients with psoriatic erythroderma in comparison to 6.3% of psoriasis vulgaris patients as controls [13]. Our study shows that this phenomenon may occur in patients who suffer from mild and moderate disease and the antibody titre correlates with intensity of dermal changes (PASI scale).…”

Serum Prolactin and ImmunoglobulinE Levels in Psoriasis Vulgaris before and after NB-UVB Therapy

“…Li et al [8] performed a study on serum immunoglobulins in psoriatic erythroderma. Serum IgE level was found to be elevated in psoriatic erythroderma patients than the controls.…”