Analysis of selected allergic reactions among psoriatic patients

Abstract

Introduction Psoriasis is a chronic and recurrent inflammatory skin disease. The aetiology is still unknown in spite of numerous scientific researches. There is very little evidence which does not provide enough knowledge about allergic reactions in psoriatic patients. Based on the fact that the epidermal barrier damage allows different allergen types to penetrate into deep layers of epidermis and skin, we can assume that it may lead to immunological reactions. Aim To investigate the allergic reaction indicators and hypersensitivity assessment about contact, inhalant and food allergens. The results were analysed with regard to clinical disease indicators and progression stage of dermal lesions. Material and methods Eighty patients with psoriasis were examined. The concentration of total IgE antibodies and allergen specific IgE antibodies (asIgE) were analysed. Standard epidermal tests and atopy patch tests were performed. All the patients were estimated for their dermatological condition based on the PASI scale. The control group consisted of 50 patients without psoriasis and allergic history. Results Significantly higher concentration of total E immunoglobulin has been stated in the patients with psoriasis. Higher concentrations of specific allergic IgE antibodies were more often observed in the examined group but the most frequently observed values were present in 1–3 class. The most common airborne allergens were birch, artemisia, timothy and rye pollens. There have not been any significant statistical differences in the case of positive epidermal test results. Conclusions There is slightly expressed hypersensitivity in psoriatic patients. This hypersensitivity degree correlates with the intensification of symptoms.

Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000‐2015: a retrospective multicentre study

“…2,22,25,63,74 In the latter patients, the atopy patch test may complement the routine diagnostic workup of a suspected allergy to aeroallergens by means of a skin prick test and/or IgE test. 16 Finally, positive aeroallergen patch tests are not limited to AD patients, 10,19 as the originally proposed name 'atopy patch test' suggests. 9 Based on our results, reflecting a reaction frequency > 2% in the patient subgroup without AD (Table 3), we propose a reduced aeroallergen patch test series for the clinical routine consisting of D. pteronyssinus, D. farinae, cat dander, mugwort, birch and timothy grass, all 200 IR/mL in pet.…”

“…In the latter patients, the atopy patch test may complement the routine diagnostic workup of a suspected allergy to aeroallergens by means of a skin prick test and/or IgE test . Finally, positive aeroallergen patch tests are not limited to AD patients, as the originally proposed name ‘atopy patch test’ suggests …”

“…In 1982, Mitchell et al 8 described in more detail that aeroallergen patch test preparations such as Dermatophagoides (D.) pteronyssinus antigen P 1 , which normally cause allergic reactions of the immediate type, can also lead to late eczematous skin reactions when applied to the skin of atopic patients for 48 h. They found that a prolonged epicutaneous application of aeroallergens could cause an exacerbation of the existing atopic skin disease. This finding marked the beginning of the development of the 1989 modified patch test called 'atopy patch test' by Ring et al, 9 which was further standardized and validated, and has since been used predominantly, though not exclusively, 10 for diagnosing eczema-worsening by aeroallergens or food allergens in patients with AD. [11][12][13][14][15][16][17] The diagnostic significance of aeroallergen patch testing for the evaluation of triggering factors of eczema in consecutive patients is still controversial.…”

Pediatric psoriasis: Should we be concerned with comorbidity? Cross‐sectional study

“…The most recent comorbidities reported in children were allergic reactions such as asthma, with higher concentration of specific allergic immunoglobulin E antibodies, which was explained by the epidermal barrier damage in psoriasis that allows different allergen types to penetrate into deep layers of the epidermis and skin.…”

Chronic Inflammation as the Underlying Mechanism of the Development of Lung Diseases in Psoriasis: A Systematic Review

“…Patients with psoriasis have been shown to present weakly expressed hypersensitivity to some inhalant, food, and contact allergens, such as birch, artemisia, timothy grass and rye pollens, house dust mites, and molds [69]. The intensity of hypersensitivity reactions correlated with PASI [69]. Sensitization to allergens also plays an important role in the development, severity, and treatment of asthma.…”