High Serum IgE Concentration in Patients with Psoriasis

Zheng, Yan

doi:10.15226/2378-1726/4/4/00163

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…The results of a study conducted by Chen et al (2017) in China, where from 92 psoriasis patients, there was a significant increase in serum IgE levels in 53.06% psoriasis patients. 2 In contrast to the study conducted by Abdelmoaty and Elkheshen (2014) in Cairo, out of 40 chronic plaque psoriasis patients, 16 (40%) had elevated serum IgE levels. The range of serum IgE levels is 0 -458 IU/ml and a median of 159.365 IU/ml.…”

Section: Methodsmentioning

confidence: 70%

“…In addition, it has been found that serum IgE levels are significantly elevated in patients with systemic lupus erythematosus, alopecia areata, and other autoimmune diseases. 2 Based on the PASI score, the highest proportion in the study subject group was psoriasis vulgaris subjects with moderate PASI scores, followed by subjects with mild PASI scores. The results of this study are in line with research conducted by Wardhana (2012) in Denpasar.…”

Section: Methodsmentioning

confidence: 89%

“…Although it is believed that psoriasis is a prototype of Th1-associated autoimmune disorders with overexpression of proinflammatory cytokines produced by Th1 cells, the elevation of serum IgE and prototype markers of Th2 immunity have also been reported in some cases of psoriasis. [1][2][3] Previously, IgE was recognized as a response to allergic reactions and a major defense mechanism against certain helminth parasitic infections but recently elevated serum IgE levels have also been reported in some cases of psoriasis. [4][5][6] It is supported with studies by Yan et al showing that in addition to elevated serum IgE, skin lesions of psoriasis patients contain more cells containing IgE and FceRI than skin without lesions.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between serum IgE levels and psoriasis area and severity index (PASI) score in psoriasis vulgaris

2021

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Introduction:Psoriasis is an immune system-mediated inflammatory disorder characterized by skin inflammation, epidermal hyperplasia, and other comorbidities. Based on medical data from H. Adam Malik hospital in 2011, the proportion of psoriasis vulgaris incidence was 0.81%. It is important to assess the severity of the disease. The most frequently used measuring instrument is the Psoriasis Area and Severity Index (PASI) score. Elevated serum IgE levels have been reported in some cases of psoriasis. The relationship between serum IgE levels and psoriasis severity is controversial. The study aimed to determine the relationship between serum IgE levels and PASI scores in psoriasis vulgaris. Method: An observational analytic study with a cross-sectional approach to 37 subjects of psoriasis vulgaris at Haji Adam Malik General Hospital Medan. Patients who meet the criteria are recorded with basic data in personal identity, history taking, physical examination, and dermatological examination. Furthermore, the calculation of the Psoriasis Area and Severity Index (PASI) score and serum IgE levels using ARCHITECT CI8200 with Quantia IgE reagent. The data will be analyzed using SPSS. Results: Psoriasis vulgaris mostly occurs in women (54.1%) with the most age group 31-45 years (40.5%). The median age was 35 years with a range of 21-67 years. The proportion of study subjects with high serum IgE levels (≥100) was 26 people (70.3%) with a median of 130 IU/ml and a range of 25-475.5 IU/ml. Based on the PASI score, the highest proportion were subjects with moderate and mild PASI scores as many as 21 people (56.8%) and 13 people (35.1%). The median PASI score was 6, with a range of 0.5 -10.40. The results of the Pearson correlation test (p) serum IgE levels and PASI scores obtained p-value = 0.0001, which indicated that the relationship between serum IgE levels and PASI scores was significant. The value of the correlation coefficient (r) of 0.909 indicates that the direction of the positive correlation with the strength of the correlation is very strong. Conclusion: There is a relationship between serum IgE levels and Psoriasis Area and Severity Index (PASI) scores in psoriasis vulgaris.

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Section: Methodsmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Relationship between serum IgE levels and psoriasis area and severity index (PASI) score in psoriasis vulgaris

2021

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Serum immunoglobulin E and Interleukin‐17 levels in patients with chronic plaque psoriasis: A case–control study

Nassar

Bakr

Elyousefi

et al. 2022

J of Cosmetic Dermatology

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Psoriasis is a common cutaneous disorder affecting about 0.17%-11.4% of adults. 1 Chronic plaque psoriasis (CPP) is the most common presentation of psoriasis, characterized by well-demarcated erythematous plaques with silvery scales, mostly on the knees, elbows, and scalp. 2 The pathogenesis of psoriasis is complex, possibly involving interactions between keratinocytes, T lymphocytes, other leukocytes, and vascular endothelium. T-helper (Th)-1 and Th17 cells are the main cells implicated in psoriasis pathogenesis. 2 High serum immunoglobulin-E (IgE) levels are frequently associated with Th2-mediated diseases. 3 However, several studies have reported elevated IgE concentrations in the sera of psoriasis patients, suggesting that IgE could be involved in psoriasis pathogenesis. [4][5][6][7] The exact cause of the elevation of IgE levels in psoriasis patients remains unknown. Interleukin (IL)-17A has been found to directly stimulate the differentiation of IgE-producing cells and

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Controversial Issues of Immunopathogenesis of Psoriasis and Atopic Dermatitis

Ambarchian,

Namazova-Baranova,

Kuzminova

et al. 2024

Annals RAMS

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Psoriasis (PsO) and atopic dermatitis (AD have much in common: both diseases are widespread, characterized by a chronic relapsing course, primarily affect the skin and lead to a quality reduction of life of patients, regardless of their age. The pathogenesis of these two dermatoses, which are the most common in the practice of a pediatric dermatologist, is quite different. PsO is a chronic inflammatory skin disease, the pathogenesis of which is associated with the involvement of the Th1 pathway: Th17 cells and the IL-23/IL-17 axis. AD, in turn, is usually associated with high levels of IL-4, IL-5, IL-13, IL-31 and IFN-γ produced by activated T-helper 2 (Th2) cells. The clinical symptoms and immunopathological responses of these two skin conditions tend to differ. However, patients with PsO may sometimes present with a skin rash resembling AD combined with intense itching and laboratory increase in immunoglobulin E (IgE) which may indicate the need to change the paradigm of dominance of only one type of T-inflammation in patients with these diseases.

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High Serum IgE Concentration in Patients with Psoriasis

Cited by 5 publications

References 17 publications

Relationship between serum IgE levels and psoriasis area and severity index (PASI) score in psoriasis vulgaris

Relationship between serum IgE levels and psoriasis area and severity index (PASI) score in psoriasis vulgaris

Serum immunoglobulin E and Interleukin‐17 levels in patients with chronic plaque psoriasis: A case–control study

Controversial Issues of Immunopathogenesis of Psoriasis and Atopic Dermatitis

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