“…An 'allergic-like dermatosis' was pre viously described during Mg2+ deficiency in mice and rats [Lowenhaupt et al, 1950;Durlach, 1975;Claverie-Benureau et al, 1980;Kruse et al, 1982], In these animals, skin inflammation was associated with numerous immunological disturbances such as eosinophilia [llungerford, 1964;Claverie-Benureau et al, 1980], increased serum IgE levels [Prouvost-Danon et al, 1975], inhibition of antibody production [Battifora, 1971;Augusti et al, 1973;Alcock and Schils, 1974;Elin, 1974: McCoy andKenney, 1974], inhi bition of lymphocyte proliferation [Battifora, 1971] and inhibition of tumor rejection [Mease. 1974], Some authors suggested that the inflam matory process was histamine-dependent [Bois and Beaunes, 1963;Geelen and Van Loghen, 1975].…”