Reduced Lectin Stimulation of Lymphocytes from Magnesium-Deficient Rats

Abstract

Spleen cells and thymocytes from Mg-deficient rats, fed a Mg-deficient diet for 10-13 weeks, incorporate [ 3 H]thymidine at half the rate of normal cells.The cells from Mg-deficient rats are less stimulated by lectins than those from normal animals.These effects correspond to the reduced content of -globulins in serum in Mg deficiency. They are caused by the altered electrolyte content of the Mg-deficient cells. Verminderte Lectin-Stimulierung der Lymphocyten von Magnesium-Mangel-RattenZusammenfassung: Lymphocyten aus Milz und Thymus von Ratten, die 10-13 Wochen Mg-arm ernährt wurden, bauen [ 3 H]Thymidin nur mit halb so hoher Geschwindigkeit ein wie die Zellen von normal ernährten Ratten.Die Lymphocyten von Mg-arm ernährten Ratten werden durch Lectine weniger stimuliert als normale Zellen.Dieses Verhalten erklärt den verminderten Gehalt des Serums an -Globulinen im Mg-Mangel. Es wird durch den veränderten Elektrolytgehalt der Lymphocyten im Mg-Mangel ausgelöst.

Magnesium-deficient hairless rat: Spleen cells mitogenic responses and variations in hormonal status

“…These results, unlike Gunther's and Averdunk's data obtained with hairy rats [5], not only show a reduced lectin stimulation of spleen cells but also an enhanced lectin response when lesions resolve. This biphasic response is similar for the four stimulants used and is accompanied in both phases by an increase in spleen cells number.…”

Antitumoral Effect of Bleomycin + Dolomite Combination Treatment, in Mice Bearing Ehrlich Ascites Carcinoma

“…Magnesium has been suggested as a one of the key elements in carcinogenesis, due to its involve ment in immunologic mechanisms related to some neoplastic diseases [1,2]. Low serum levels of mag nesium elevate the concentration of arachidonic acid, and some of its metabolites, e.g.…”