Serum<i>n</i>-3 polyunsaturated fatty acids are inversely associated with longitudinal changes in depressive symptoms during pregnancy

Pinto, Thatiana de Jesus Pereira; Freitas-Vilela, Ana Amélia; Farias, Dayana Rodrigues; Lepsch, Jaqueline; Cunha, Geraldo Marcelo da; Vaz, Juliana dos Santos; Factor-Litvak, Pam; Kac, Gilberto

doi:10.1017/s204579601500116x

Cited by 23 publications

(22 citation statements)

References 48 publications

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“…Moreover, our study also showed pregnant women with PND tend to have higher levels of AA and n-6 PUFAs. This is further supported by other observational studies indicating that higher levels of EPA and DHA act as protective factor from MDD while a higher n-6/n-3 ratio acts as a risk factor of MDD in pregnant women (De Vriese et al, 2003;Pinto et al, 2016). Moreover, higher concentrations of DHA in breast milk and greater seafood consumption (rich in DHA) have been associated with lower prevalence rates of postpartum depression (Hibbeln, 2002).…”

Section: Pnd Group Had Lower Levels Of N-3 Pufassupporting

confidence: 75%

“…For examples, prenatal depressive symptoms are associated with lower plasma DHA in Japanese population (Shiraishi et al, 2015). Another association study further indicates that patients with higher level of EPA and DHA have lowered risks for developing depressive symptoms (De Vriese et al, 2003), while a higher omega-6 (n-6)/n-3 ratio increases the odds of having depressive symptoms (De Vriese et al, 2003;Pinto et al, 2016). In contrast to the supporting evidence of PUFAs in PND, Sallis et al (Sallis et al, 2014) only found weak associations between n-3 PUFAs and PND.…”

Section: Introductionmentioning

confidence: 99%

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Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy

Chang

Lin

et al. 2018

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Pnd Group Had Lower Levels Of N-3 Pufassupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy

Chang

Lin

et al. 2018

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…n‐3 fatty acids show an anti‐inflammatory effect, while n‐6 shows pro‐inflammatory effect. PUFA modifies important monoamine neurotransmitters, such as serotonin and dopamine, which are involved in the pathophysiology of depression and other mental disorders …”

Section: Discussionmentioning

confidence: 99%

Screening of depression in overweight and obese pregnant women and its predictors

Salehi‐Pourmehr

Dolatkhah

Gassab-Abdollahi

et al. 2019

J of Obstet and Gynaecol

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Aim: The aim of this study was to investigate the screening result of depression and its predictors in overweight and obese pregnant women in second and third trimester of pregnancy. Methods: The present cross-sectional study was carried out on 232 overweight or obese pregnant women older than 18 years in the second and third trimesters of pregnancy. Edinburgh Postnatal Depression Scale questionnaire, the International Physical Activity Questionnaire and the Food Record were used. Independent t-test, Man-Whitney U, Pearson and Spearman correlation test, independent t-test, one-way analysis of variance and, multivariate linear regression were applied for data analysis using SPSS 21.Results: The results of the study showed that the mean (standard deviation) score of depression was 10.1 (4.4), and it was similar in both overweight and obese women (P = 0.784). Median (quartile 25-75) of physical activity was 891.0 (495.0-1336.0) metabolic equivalent of task -min/week. The total physical activity in obese women was statistically higher than overweight ones (P = 0.032). In linear regression model, the variables of parity, body mass index, physical activity education, protein, fat, oleic acid, monounsaturated fatty acids, potassium, magnesium, and zinc were the strong predictors of depression, and along with the others explained the 80% of variances. Conclusion: Considering the fact that nearly one-third of overweight and obese women in the present study were positive for depression screening, it is important to pay attention to strong predictors of depression in these women.

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“…ОБЗОРЫ эффекты, связанные с приемом омега-3 ПНЖК во время беременности: увеличение объема околоплодных вод при маловодии [18]; эффективная профилактика депрессии во время беременности и после родов [19]; профилактика сниженной массы тела при рождении (в частности, крупномасштабное исследование 12 373 беременных показало, что низкие концентрации омега-3 ПНЖК в плазме крови были связаны с более низкой массой тела новорожденных (отношение шансов 1:4) [4]); снижение риска развития аллергий у детей [20] (например, пищевая аллергия на яйца встречалась только у 9% детей, рожденных от матерей, получавших 900 мг/сут омега-3 ПНЖК во время беременности, а в контроле -у 15% детей). Дети от матерей, получавших дотации омега-3 ПНЖК во время беременности, имели более высокую степень восприятия и воспроизведения речи по шкалам МакАртура и Бейли на 12, 14 и 18-й месяцы жизни [21].…”

Section: The Work Was Done Under Grant 16-07-01129 Of the Rfbrunclassified

New trends in nutritional support for pregnancy

Gromova¹,

Torshin²,

Tetruashvili³

et al. 2018

Akusherstvo i ginekologiia

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ФГБОУ ВО Ивановская государственная медицинская академия Минздрава России, г. Иваново 3 ФГБУ Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России Цель исследования. Провести анализ роли специализированных витаминно-минеральных комплексов (ВМК) в поддержке беременности на основе опубликованных мета-анализов и результатов клинических исследований. Материал и методы. Проведен отбор релевантных публикаций в научной базе цитирования PubMed и, дополнительно в Google Scholar за последние 10 лет. Результаты. Отмечается положительная тенденция отказа от менее усвояемых и, в ряде случаев, более токсических неорганических форм микронутриентов к формам с более высокой биодоступностью. Не менее важными особенностями являются использование биологически активных форм микронутриентов и все более широкое применение омега-3 полиненасыщенных жирных кислот в составе ВМК для беременных. Заключение. Применение ВМК у беременных с высокой биодоступностью позволяет осуществить первичную профилактику пороков развития плода. Наличие в составе ВМК омега-3 полиненасыщеных жирных кислот снижает риск развития нарушений функции зрения и перинатальной энцефалопати у плода. Ключевые слова: нутрициальная поддержка беременности, профилактика врожденных пороков, липофер, метилфолиевая кислота, докозагексаеновая кислота, прегнотон мама. Работа выполнена по гранту 16-07-01129 РФФИ. Авторы заявляют об отсутствии возможных конфликтов интересов.

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Serumn-3 polyunsaturated fatty acids are inversely associated with longitudinal changes in depressive symptoms during pregnancy

Cited by 23 publications

References 48 publications

Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy

Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy

Screening of depression in overweight and obese pregnant women and its predictors

New trends in nutritional support for pregnancy

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