Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis

Leach, N.; Dronca, Eleonora; Vesa, Ștefan Cristian; Sampelean, Dorel; Craciun, Cristina; Lupşor, M.; Crişan, Dana; Tarau, Roxana; Rusu, Razvan; Para, Ioana; Grigorescu, Mircea

doi:10.1016/j.ejim.2014.09.007

Cited by 76 publications

(58 citation statements)

References 43 publications

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“…In the study of Leach et al (16), plasma fasting glucose, serum insulin and HOMA-IR were all significantly higher in patients with NASH than in the control group. Diez-Rodriquez (17) found that HOMA-IR was statistically related to the necroinflammatory grade.…”

Section: Discussionmentioning

confidence: 99%

Role of oxidative stress and insulin resistance in disease severity of non-alcoholic fatty liver disease

Köroğlu

Canbakan²,

Atay³

et al. 2016

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

Role of oxidative stress and insulin resistance in disease severity of non-alcoholic fatty liver disease

Köroğlu

Canbakan²,

Atay³

et al. 2016

Turk J Gastroenterol

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“…Increased levels of oxidative stress play a role in the pathogenesis of liver diseases, including chronic hepatitis C virus infection (CHC) and nonalcoholic steaohepatitis (NASH) (41). However, Patients with HCV and HCV-NAFLD groups had altered blood lipid profiles, higher IR, elevated liver enzyme activities, imbalances in anti-oxidant defense (42).…”

Section: Resultsmentioning

confidence: 99%

Oxidative stress biomarkers among Saudi patients with non-alcoholic steatohepatitis versus chronic hepatitis C

Al-Jiffri

2016

Electron J Gen Med

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Objective: As oxidative status may be an influential factor for increasing the progress of the disease and decreasing the effectiveness of the treatment, the aim of this study was to measure the oxidative stress and anti-oxidative markers among Saudi patients with chronic hepatitis C (CHC) versus nonalcoholic steatohepatitis (NASH). Methods: This study was carried out on a sample of 150 consecutive patients (75 with CHC and 75 with NASH), selected from gastroenterology outpatient clinic, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Also, this study included 75 healthy volunteers, mostly, relatives of the patients who came with them to the clinic. Measurements of oxidative stress and anti-oxidative stress markers were measured for all participants. Results:The mean values of oxidative stress markers included conjugated dienes (CD), malondialdehyde (MDA), nitric oxide (NO) and myeloperoxidase (MPO) were significantly elevated in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly elevated in patients with NASH than patients with CHC. However, the mean values of anti-oxidative stress markers include glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione (GSH), arylesterase (AE) and paraoxonase (PON) were significantly reduced in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly reduced in patients with NASH than patients with CHC. Conclusion: In this study, patients with NASH have higher levels of oxidative and lower anti-oxidant markers than patients with CHCs.

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“…We read with great interest the recently published article by Leach et al [1]. In this study, it was aimed to evaluate serum homocysteine (Hcy) levels and oxidative stress status in patients with biopsy-proven non-alcoholic steatohepatitis (NASH) and to check their possible association with cardiovascular risk measured by carotid artery intima-media thickness (c-IMT).…”

Section: Dear Editormentioning

confidence: 99%

Proper cut-off points to distinguish patients with NASH from non-NASH

Sertoğlu¹,

Kayadibi

Uyanık³

2015

European Journal of Internal Medicine

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Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis

Cited by 76 publications

References 43 publications

Role of oxidative stress and insulin resistance in disease severity of non-alcoholic fatty liver disease

Role of oxidative stress and insulin resistance in disease severity of non-alcoholic fatty liver disease

Oxidative stress biomarkers among Saudi patients with non-alcoholic steatohepatitis versus chronic hepatitis C

Proper cut-off points to distinguish patients with NASH from non-NASH

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