Role of oxidative stress and insulin resistance in disease severity of non-alcoholic fatty liver disease

“…(26) The subsequent development of the process promotes fibrogenesis in liver cells. (10,11) Excessive accumulation of toxic LPO products, especially expressed in Mongoloid patients, may exacerbate the initial morphofunctional changes in cells, and, accordingly, aggravate the course of the disease.…”

Section: Resultsmentioning

confidence: 99%

“…(10) Malonic dialdehyde also activates stellate cells for collagen production, which invariably leads to cell fibrosis. (11) In this connection, it seems appropriate to study the intensity of OS, as well as to prescribe a complex of antioxidants, selected individually, taking into account the nature of the imbalance detected, for this category of patients. (12,13) To develop a personalized method of treatment, it is also important to take into account the patient`s ethnicity.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Assessment in Different Ethnic Groups of Girls with Exogenous Constitutional Obesity Complicated by Non-Alcoholic Fatty Liver Disease

Darenskaya¹,

Rychkova²,

Zhdanova³

et al. 2019

IJBM

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The purpose of this study was to assess the lipid peroxidation (LPO) and antioxidative defense (AOD) indicators in different ethnic groups of adolescent girls with exogenous constitutional obesity (ECO) and non-alcoholic fatty liver disease (NAFLD). Materials and Methods: A total of 20 Mongoloid teenage girls and 20 Caucasian teenage girls with NAFLD (Clinical group 1 and Clinical group 2, respectively) on the background of ECO of the first degree were examined. For comparison, data of 28 healthy Mongoloid teenage girls (Control group 1) and 20 Caucasian teenage girls (Control group 2) were used. The plasma level of antioxidant parameters (total antioxidant activity [TTA], SOD activity, α-tocopherol and retinol) and primary/secondary products of LPO (conjugated dienes [CD], ketodienes and conjugated trienes [KD-CT], and thiobarbituric acid reactive substances [TBARS]) were determined using spectrophotometric and fluorometric methods. Results: Evaluation of the activity of LPO reactions in Clinical group 1 indicated an increase in the content of CD, KD-CT, and TBARS relative to Control group 1. In Clinical group 2, we found an increased CD content relative to Control group 2. Interethnic differences resulted in elevated levels of KD-CT in Clinical group 1 compared to Clinical group 2.In the parameters of the AOD system, we observed reduced levels of TAA, retinol and glutathione-S-transferase (G-S-T) activity in Clinical group 2 compared to Control group 2. In Clinical group 1, we observed reduced levels of α-tocopherol, retinol and G-S-T activity compared to Control group 1. There were no differences in the parameters of the AOD system between Clinical group 1 and Clinical group 2. Conclusion: The results obtained indicate high activity of LPO processes and severe deficiency of antioxidant factors in Mongoloid girls with ECO and NAFLD in comparison with Caucasian girls with obesity and NAFLD and the control group. The obtained results allow us to recommend administration of antioxidant drugs in addition to basic therapy in comprehensive treatment of patients with NAFLD.

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“…Low-carbohydrate diets like the KD quickly diminish hepatic fat, which is known to lead to other metabolic abnormalities 23. Oxidative stress and liver inflammation, as measured by malondialdehyde, superoxide dismutase, AST, ALT and GGT increase in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) 24. Basaranoglu et al reveal that ‘hepatic de novo lipogenesis (fatty acid and triglyceride synthesis) is increased in patients with NAFLD,’ further contributing to fatty liver 25…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of obesity and insulin resistance via ketogenic diet status post Roux-en-Y

Handley¹,

Bentley

Brown

et al. 2018

BMJ Case Reports

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This is a single case of a 65-year-old American woman who presented with substantial weight gain and insulin resistance (IR) post-Roux-en-Y gastric bypass (RYGB) surgery. Before RYGB, she had reached 340 lbs (155 kg) and a body mass index (BMI) of 56.6 kg/m The surgery resulted in a 70 lbs (32 kg) weight loss, bringing her BMI, per cent total weight loss (%TWL) and per cent excess weight loss (%EWL) to 44.9 kg/m, 20.6% and 36.8%, respectively. Unfortunately, her BMI would return to 53.6 kg/m, nearly her pre-RYGB BMI. It was then she sought the guidance of a primary care physician with expertise in nutrition and medical management of obesity, who placed her on a ketogenic diet. One year later, she had lost 102 lbs (46.4 kg), resulting in a BMI, %TWL and %EWL of 36.6 kg/m, 31.7%, and 63.1%, respectively, also further resulting in significant improvements of her inflammatory biomarkers. This case presentation will explore current literature, covering the effects of obesity on IR, pre-diabetes and other disease-provoking inflammatory biomarkers.

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Role of oxidative stress and insulin resistance in disease severity of non-alcoholic fatty liver disease

Cited by 54 publications

References 25 publications

Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus

Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus

Oxidative Stress Assessment in Different Ethnic Groups of Girls with Exogenous Constitutional Obesity Complicated by Non-Alcoholic Fatty Liver Disease

Successful treatment of obesity and insulin resistance via ketogenic diet status post Roux-en-Y

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