Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis?

Shargorodsky, Marina; Boaz, Mona; Pasternak, Shmuel; Hanah, R.; Matas, Zipora; Fux, Asora; Beigel, Yitzhak; Mashavi, Margarita

doi:10.1002/dmrr.902

Cited by 41 publications

(31 citation statements)

References 77 publications

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“…The generation of advanced glycation end products in response to hyperglycemia has been suggested to create cross-bridges between macromolecules in the arterial wall, which can result in arterial stiffening (3,17). In addition, homocysteine has been shown to increase smooth muscle cell proliferation (9) and is associated with the development of atherosclerosis in patients with diabetes (42). It is well known that women with GDM are at increased risk of developing hypertensive disorders (gestational hypertension and preeclampsia) during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Influence of hyperglycemia during and after pregnancy on postpartum vascular function

Davenport

Goswami

Shoemaker

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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Section: Discussionmentioning

confidence: 99%

Influence of hyperglycemia during and after pregnancy on postpartum vascular function

Davenport

Goswami

Shoemaker

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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“…These compounds have been implicated in atherogenesis through oxidation of low-density lipoprotein, suppression of nitric oxide synthesis, arterial stiffness, endothelial inflammation, and foam cell formation [19,20]. Chronic hyperhomocysteinaemia reduces the activity of superoxide dismutase, which is important in the dismutation of superoxide radicals [21].…”

Section: Resultsmentioning

confidence: 99%

The relation between vitamin B12 and SYNTAX score

et al. 2017

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A b s t r a c tBackground: Vitamin B12 is required in the metabolism of homocysteine. Vitamin B12 deficiency has been implicated in endothelial dysfunction and cardiovascular disease via hyperhomocysteinaemia. However, the association of vitamin B12 and the severity of coronary artery disease has not been studied to date. Aim:This study was conducted with the aim of evaluating the relationship between vitamin B12 and SYNTAX score.Methods: Medical records of consecutive patients who underwent coronary artery bypass grafting surgery were retrospectively reviewed. The study group consisted of 127 patients. Vitamin B12, other biochemical parameters, clinical and echocardiographic parameters, and SYNTAX score were evaluated for all patients.Results: Patients with vitamin B12 deficiency had a higher prevalence of cardiovascular risk factors such as diabetes mellitus, and history of transient ischaemic attack/stroke and heart failure. The SYNTAX score was significantly higher in patients with vitamin B12 deficiency (29.2 ± 4.9 vs. 22.5 ± 4.5, p < 0.05). Conclusions:In our study, we found a significant relationship between vitamin B12 deficiency and SYNTAX score, demonstrating the severity and complexity of coronary artery disease.

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“…It's well known that there is a strong association between vitamin B12 deficiency and increased oxidative stress [29][30][31]. And also, CorT is associated with increased oxidative stress process such as aging, HT, DM, and subclinic atherosclerosis .…”

Section: Discussionmentioning

confidence: 99%

“…These compounds have been implicated in atherogenesis through oxidation of low-density lipoprotein, supression of nitric oxide synthesis, arterial stifness, endothelial inflamation and foam cell formation [29,30]. Chronic hyperhomocysteinemia reduced activity of superoxide dismutase, which is important in the dismutation of superoxide radicals [30].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Vitamin B12 in Patients with Coronary Tortuosity

Cerit

Kemal

Günsel

et al. 2016

Preprint

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Background: Vitamin B 12 deficiency has been implicated in endothelial dysfunction and cardiovascular disease via hyperhomocysteinemia. Coronary tortuosity (CorT) is a common coronary angiography finding. The etiology, clinical implication and long term prognosis are still not well clarified. This study was conducted with the aim to evaluate the relationship between CorT and vitamin B12. Subjects and Method: The medical records of consecutive patients, who underwent coronary angiography, were retrospectively reviewed. The study group consisted of 1624 patients. Taking into consideration the inclusion criteria, 212 patients with CorT and 210 patients with normal coronary angiographies (control group) were included in the study. Vitamin B12, other biochemical parameters, clinical and echocardiographic parameters, and CorT score were evaluated in all patients. CorT is defined as fixed 3 bends during both systole and diastole, with each bend ≥45 °. Results: Patients with CorT had higher prevalence of older, female gender, hypertension, current smoking. Vitamin B12 was significantly decreased in patient with CorT (134.7±47.8 vs 239.6±53.8 p<0.001). On multivariate analysis age, female gender, hypertension, diabetes mellitus and vitamin B12 were independent predictors for CorT (OR 1.56; 95% CI: 1.247-1.962; p < 0.001, OR 1.628; 95% CI: 1.376-2.048; p<0.001, OR 1.865; 95% CI: 1.387-2.695; p<0.001, OR 1.362; 95% CI: 1.184-1.726; p<0.001, OR 1.862; 95% CI: 1.486-2.674; p<0.001, respectively). Conclusion: In our study, we have founded a significant relationship between vitamin B12 deficiency and CorT.

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Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis?

Cited by 41 publications

References 77 publications

Influence of hyperglycemia during and after pregnancy on postpartum vascular function

Influence of hyperglycemia during and after pregnancy on postpartum vascular function

The relation between vitamin B12 and SYNTAX score

Assessment of Vitamin B12 in Patients with Coronary Tortuosity

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