Influence of hyperglycemia during and after pregnancy on postpartum vascular function

Davenport, Margie H.; Goswami, Ruma; Shoemaker, J. Kevin; Mottola, Michelle F.

doi:10.1152/ajpregu.00115.2011

Cited by 30 publications

(44 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 13 studies, [7][8][9][10][11][12][13][14][15]17,[19][20][21] the control groups had lower fasting blood sugar (FBS) and OGTT levels than all previous GDM groups, while Fakhrzadeh et al 16 reported no difference between groups (Table 3). Akinci et al 18 noted that the prevalence of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) was higher in the previous GDM group after adjusting for prepregnancy BMI, family history of T2DM and postpartum diabetes.…”

Section: Cardiometabolic Risk Assessmentmentioning

confidence: 98%

“…Two studies 10,17 asked subjects to refrain from smoking 'on the day of the study', while Volpe et al 13 and Gunderson et al 21 included subjects who were smokers. Hannemann et al 10,a Hu et al 11,a Volpe et al 13,b Fakhrzadeh et al 16,b Akinci et al 17,b Akinci et al 18,b Gunderson et al 21,b Age ( Brewster et al 15,b Freire et al 19,b Anastasiou et al 7,b Bo et al 9,b Pleiner et al 12,b Heitritter et al 20,b Age ( Brewster et al 15,b Freire et al 19,b Anastasiou et al 7,b Bo et al 9,b Pleiner et al 12,b Heitritter et al 20 Banerjee et al 8,a Davenport et al 14,b Age ( studies 7,10,11,14,17 reported waist-to-hip ratio, with previous GDM women having a higher ratio in three studies. 2,11,17 Of those reporting, waist circumference ranged from 71.7 ± 8.8 to 87 ± 0.6 cm in the controls and 73.6 ± 5.7 to 92 ± 13.19 cm in the previous GDM cases (Table 2).…”

Section: Subject Characteristicsmentioning

confidence: 99%

“…Volpe et al 13,a Akinci et al 17,a Bo et al 9,a Pleiner et al 12,a Heitritter et al 20,a Hannemann et al 10,b Hu et al 11,b Anastasiou et al 7,a Fasting glucose (mmol/L) Cases Davenport et al 14 Banerjee et al 8,b Davenport et al 14,a Cholesterol (mmol/L) group, age was associated with arterial stiffness in both the carotid artery and aorta; however, in the previous GDM group, this trend was not shown. Similarly, Volpe et al 13 found increased CIMT in previous GDM women compared to controls 2 years postpartum, despite no difference in BMI between groups and only one woman meeting the criteria for metabolic syndrome.…”

Section: Vascular Structure and Function Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Review of gestational diabetes mellitus effects on vascular structure and function

Jensen

Chik

Ryan

2016

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

Vascular dysfunction has been described in women with a history of gestational diabetes mellitus. Furthermore, previous gestational diabetes mellitus increases the risk of developing Type 2 diabetes mellitus, a risk factor for cardiovascular disease. Factors contributing to vascular changes remain uncertain. The aim of this review was to summarize vascular structure and function changes found to occur in women with previous gestational diabetes mellitus and to identify factors that contribute to vascular dysfunction. A systematic search of electronic databases yielded 15 publications from 1998 to March 2014 that met the inclusion criteria. Our review confirmed that previous gestational diabetes mellitus contributes to vascular dysfunction, and the most consistent risk factor associated with previous gestational diabetes mellitus and vascular dysfunction was elevated body mass index. Heterogeneity existed across studies in determining the relationship of glycaemic levels and insulin resistance to vascular dysfunction.

show abstract

Section: Cardiometabolic Risk Assessmentmentioning

confidence: 98%

Section: Subject Characteristicsmentioning

confidence: 99%

Section: Vascular Structure and Function Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Review of gestational diabetes mellitus effects on vascular structure and function

Jensen

Chik

Ryan

2016

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

show abstract

“…These results seem to suggest that the determinant status of the aortic stiffness was mostly related to glycemic status. Davenport et al (38) assessed postpartum arterial stiffness in a study and found that carotid artery distensibility was low in gestational DM patients with ongoing hyperglycemia during the postpartum period; it was ascribed to the relation between hyperglycemia and aortic stiffness via a similar mechanism as mentioned above.…”

Section: Discussionmentioning

confidence: 94%

Effect of Human Gestational Diabetes Mellitus on Arterial Stiffness

İnci¹

2014

Acta Endo (Buc)

View full text Add to dashboard Cite

Background. The present study aims to evaluate the parameters for aortic stiffness by comparing gestational diabetes mellitus (GDM) with a healthy control group via transthoracic echocardiography.Methods. This was a cross-sectional study involving monitoring of 62 pregnant women (33 with GDM and 29 with uncomplicated pregnancy as controls) during the third trimester. The aortic strain, aortic distensibility, and aortic stiffness values were measured via transthoracic echocardiography. Measurements of GDM group were repeated after 6 months.Results. Blood pressure levels, heart rate, and basic echocardiography were similar in both groups, but BMI was significantly higher in the GDM group (p <0.001). Whereas, aortic strain and distensibility were significantly lower in the GDM group (p <0.001). Aortic stiffness index was significantly higher in the GDM group (p <0.001). Aortic stiffness parameters did not exhibit any significant difference between the insulin-receiving GDM group and the diet-controlled GDM group. Postprandial glucose levels were correlated positively with the aortic stiffness index (p=0.04) andnegatively with the level of aortic strain (p<0.01) and distensibility (p=0.03). The aortic stiffness in normoglycemic postpartum group at 6 th month showed a significant improvement (p<0.001); but not in hyperglycemic postpartum group.Conclusion. Arterial stiffness was increased in women with GDM compared to the control group. A correlation between postprandial glucose and arterial stiffness was found. The aortic stiffness can be affected irreversibly from increased clinical and subclinical levels of glucose in postpartum period.

show abstract

“…FMD was significantly lower in the former two groups than in the latter two. Interestingly, FMD no longer differed significantly between the four groups after controlling for glucose AUC, which goes to show the importance of postpartum hyperglycemia in determining endothelial dysfunction after pregnancy [31]. After adjusting for age and blood pressure levels, Fakhrzadeh et al reported a significant reduction in FMD 4 years after delivery in women with a history of GDM [32] by comparison with control women (26 ± 0.11% versus 19.32 ± 0.05%; p = 0.003).…”

Section: Early Changes In Vascular Structure and Function In Womenmentioning

confidence: 99%

Gestational Diabetes Mellitus and Future Cardiovascular Risk: An Update

Burlina

Dalfra

Chilelli

et al. 2016

International Journal of Endocrinology

View full text Add to dashboard Cite

The prevalence of gestational diabetes mellitus is increasing in parallel with the rising prevalence of type 2 diabetes and obesity around the world. Current evidence strongly suggests that women who have had gestational diabetes mellitus are at greater risk of cardiovascular disease later in life. Given the growing prevalence of gestational diabetes mellitus, it is important to identify appropriate reliable markers of cardiovascular disease and specific treatment strategies capable of containing obesity, diabetes, and metabolic syndrome in order to reduce the burden of cardiovascular disease in the women affected.

show abstract

Influence of hyperglycemia during and after pregnancy on postpartum vascular function

Abstract: Davenport MH, Goswami R, Shoemaker JK, Mottola MF. Influence of hyperglycemia during and after pregnancy on postpartum vascular function.

Cited by 30 publications

References 45 publications

Review of gestational diabetes mellitus effects on vascular structure and function

Review of gestational diabetes mellitus effects on vascular structure and function

Effect of Human Gestational Diabetes Mellitus on Arterial Stiffness

Gestational Diabetes Mellitus and Future Cardiovascular Risk: An Update

Contact Info

Product

Resources

About