Serum heart type fatty acid binding protein levels in metabolic syndrome

Abstract

Heart type fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is closely associated with acute coronary syndrome, hypertrophic and dilated cardiomyopathy, heart failure, stroke, obstructive sleep apnea syndrome, pulmonary embolism. The aim of this study was to investigate serum H-FABP value in the patients with metabolic syndrome (MetS). We measured serum H-FABP levels in 55 consecutive patients with MetS, and 73 age-matched control subjects by using a sandwich enzyme-linked immunosorbent assay. Serum H-FABP levels were significantly higher in patients with MetS than in control subjects 18.37 ± 13.0 and 7.9 ± 6.5 ng/ml, respectively, (P < 0.001). Serum H-FABP levels were significantly higher in patients with diabetic MetS than in without diabetic MetS, 24.0 ± 10.2 and 13.9 ± 12.6 ng/ml, respectively, (P: 0,003). There were statistically significant differences between patients without diabetic MetS and control subjects, 13.8 ± 12.6 and 7.9 ± 6.5 ng/ml, respectively, (P = 0.023). Patients with MetS have an increased risk of death from cardiovascular diseases. H-FABP seems to be a marker that will enable the detection of cardiac injury in the early asymptomatic period in patients with MetS.

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“…Akbal et al 36,37 . Demonstrated, and for the first time, that elevated circulating serum levels of H-FABP may provide important prognostic information in patients with MetS and reported that patients with MetS have increased serum levels of H-FABP, indicating its promise as a marker for detection of cardiac injury in patients with MetS.…”

Liver fatty acid-binding protein as a diagnostic marker for non-alcoholic fatty liver disease

“…Various FABPs have been investigated for clinical use in detecting early tissue damage. When there is ongoing damage, FABP is measurable in serum [7][8][9][10][11][12][13][14][15][16]. The designation of each of the proteins in this family has been taken from the tissue where it was originally isolated, and key members of this group of proteins include liver fatty acid-binding protein (L-FABP), intestinal FABP, heart FABP and epidermal FABP [17].…”

Elevated Serum Heart-Type Fatty Acid-Binding Protein in the Convalescent Stage Predicts Long-Term Outcome in Patients Surviving Acute Myocardial Infarction

“…24, 25 Akbal et al reported that H-FABP is significantly elevated in patients with metabolic syndrome, particularly in diabetic patients. 26 We previously reported that post-AMI diabetic patients have an increased risk of admission for HF and that high-sensitivity C-reactive protein (hs-CRP) in the convalescent stage of AMI is significantly higher in diabetic patients who were readmitted for HF than in those who were not. 17 Scirica et al also reported that hs-CRP in the convalescent stage of ACS is significantly higher in patients rehospitalized for HF.…”