Liver fatty acid-binding protein as a diagnostic marker for non-alcoholic fatty liver disease

Akbal, Erdem; Koçak, Erdem; Akyürek, Ömer; Köklü, Seyfettin; Batgi, Hikmetullah; Şeneş, Mehmet

doi:10.1007/s00508-014-0680-8

Cited by 23 publications

(30 citation statements)

References 26 publications

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“…In turn, deficiency of carboxylesterases: CES1 and CES2, which metabolize triacylglycerols and cholesteryl esters, resulted in hepatic steatosis, obesity and hyperlipidaemia . Noteworthy, the loss of proteins participated in cholesterol transport: SCP‐2 and L‐FABP induces lipid accumulation in hepatocytes and higher levels of L‐FABP were observed in patients with NAFLD . Interestingly, proteins involved in reverse cholesterol transport from tissues to the liver, such as ApoA‐I and PON1 (components of high‐density lipoprotein [HDL]) were diminished in the liver of apoE/eNOS‐DKO mice.…”

Section: Discussionmentioning

confidence: 99%

Quantitative proteomics reveals decreased expression of major urinary proteins in the liver of apoE/eNOS‐DKO mice

Stachowicz

Olszanecki

Suski

et al. 2018

Clin Exp Pharma Physio

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Endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) plays an important role, not only in endothelium-dependent vasodilation but also in lipid and glucose homeostasis in the liver and exerts beneficial effects on mitochondrial biogenesis and respiration. Thus, the aim of our study was to use iTRAQ-based quantitative proteomics to investigate the changes in protein expression in the mitochondrial and cytosolic fractions isolated from the liver of the double (apolipoprotein E (apoE) and eNOS) knockout (apoE/eNOS-DKO) mice as compared to apoE KO mice (apoE ) - an animal model of atherosclerosis and hepatic steatosis. Collectively, the deficiency of eNOS resulted in increased expression of proteins related to gluconeogenesis, fatty acids and cholesterol biosynthesis as well as the decreased expression of proteins participated in triglyceride breakdown, cholesterol transport, protein transcription & translation and processing in endoplasmic reticulum (ER). Moreover, one of the most downregulated proteins were major urinary proteins (MUPs), which are abundantly expressed in the liver and were shown to be involved in the regulation of lipid and glucose metabolism. The exact functional consequences of the revealed alterations require further investigation.

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Section: Discussionmentioning

confidence: 99%

Quantitative proteomics reveals decreased expression of major urinary proteins in the liver of apoE/eNOS‐DKO mice

Stachowicz

Olszanecki

Suski

et al. 2018

Clin Exp Pharma Physio

View full text Add to dashboard Cite

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“…Another study suggested that elevation of serum L-FABP levels were associated with the degree of fibrosis and inflammation, indicating that serum L-FABP could be a non-invasive marker in determining the severity of fibrosis and inflammation in patients with non-alcoholic steatohepatitis [19]. One study demonstrated that elevated serum L-FABP levels were related to ongoing liver damage in patients with non-alcoholic fatty liver disease [20]. Our study provided a comparison between patients with acute hepatitis, There was statistically significant difference between acute hepatitis and hepatic encephalopathy (p<0.01) b: There was statistically significant difference between acute hepatitis and stable cirrhosis (p<0.01) c: There was statistically significant difference between hepatic encephalopathy and control subjects (p<0.05) d: There was statistically significant difference between stable cirrhosis and control subjects (p<0.001) e: There was statistically significant difference between acute hepatitis and control subjects (p<0.001) f: There was statistically significant difference between HE and SC (p<0.001).…”

Section: Discussionmentioning

confidence: 99%

The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis

Çakır

Toker

Ataseven

et al. 2017

JCDR

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“…However, increased serum concentrations of L-FABP have recently been shown with obesity, insulin resistance, and high blood pressure, all in the absence of acute tissue injury (63,64). Studies have also suggested it could be an early biomarker for lung damage in moderate acute respiratory failure and a diagnostic marker for nonalcoholic hepatic steatosis (65,66). Although the contribution of serum L-FABP to urinary L-FABP may be minimal, as suggested by Kamijo et al (67), the test needs validation across a spectrum of clinical settings to determine optimal cutoff values.…”

Section: Liver-type Fatty-acid-binding Proteinmentioning

confidence: 99%

Biomarkers for Early Detection of Acute Kidney Injury

Rizvi

Kashani

2017

The Journal of Applied Laboratory Medicine

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Background: Acute kidney injury (AKI) is common in hospitalized patients and is associated with increased morbidity, mortality, and cost. Currently, AKI is diagnosed after symptoms manifest; available diagnostic tests (e.g., serum creatinine, urine microscopy, urine output) have limited ability to identify subclinical AKI. Because of the lack of treatment strategies, AKI typically is managed with supportive measures. However, strategies exist that may prevent renal insults in critically ill patients; therefore, early recognition of AKI is crucial for minimizing damage propagation. Content: Experimental and clinical studies have identified biomarkers that may facilitate earlier recognition of AKI or even identify patients at risk of AKI. Such biomarkers might aid in earlier implementation of preventive strategies to slow disease progression and potentially improve outcomes. This review describes some of the most promising novel biomarkers of AKI, including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (KIM-1), interleukin 18 (lL-18), liver-type fatty-acid-binding protein (L-FABP), insulin-like-growth-factor-binding protein 7 (IGFBP7), and tissue inhibitor of metalloproteinase 2 (TIMP-2). Summary: We discuss biomarker test characteristics, their strengths and weaknesses, and future directions of their clinical implementation. IMPACT STATEMENT Acute kidney injury (AKI) affects millions of people in the US and increases morbidity, mortality, and healthcare expenditures. Available laboratory tests for early and accurate diagnosis of AKI have significant limitations. Novel biomarkers that predict development of AKI earlier are critically needed because they allow implementation of preventive strategies that potentially improve clinical outcomes. In this report, we review the most promising biomarkers of AKI that have been investigated during the past 2 decades and present a model for clinical implementation and areas for future investigation.

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Liver fatty acid-binding protein as a diagnostic marker for non-alcoholic fatty liver disease

Abstract: Serum L-FABP can be considered as a new diagnostic marker for detecting non-alcoholic fatty liver disease.

Cited by 23 publications

References 26 publications

Quantitative proteomics reveals decreased expression of major urinary proteins in the liver of apoE/eNOS‐DKO mice

Quantitative proteomics reveals decreased expression of major urinary proteins in the liver of apoE/eNOS‐DKO mice

The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis

Biomarkers for Early Detection of Acute Kidney Injury

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