Elevated Serum Heart-Type Fatty Acid-Binding Protein in the Convalescent Stage Predicts Long-Term Outcome in Patients Surviving Acute Myocardial Infarction

Matsumoto, S; Nakatani, Daisaku; Sakata, Yasuhiko; Suna, Shinichiro; Shimizu, Masahiko; Usami, Masaya; Hara, Masahiko; Sumitsuji, Satoru; Nanto, Shinsuke; Sasaki, Tatsuya; Hamasaki, Toshimitsu; Sato, Hiroshi; Hori, Masatsugu; Komuro, Issei

doi:10.1253/circj.cj-12-0999

Cited by 23 publications

(13 citation statements)

References 28 publications

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“…Cardiac troponin T, which is a myofibrillar component of cardiomyocytes, is an established marker for myocardial damage [7] . Myocardial damage markers can be used to risk stratify patients with various types of heart disease [8] , [9] , [10] , [11] . However, the prognostic value of these myocardial damage markers has not yet been elucidated in patients with PAD.…”

Section: Introductionmentioning

confidence: 99%

Heart-type fatty acid binding protein and high-sensitivity troponin T are myocardial damage markers that could predict adverse clinical outcomes in patients with peripheral artery disease

et al. 2015

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BackgroundDespite many recent advances in endovascular therapy (EVT), peripheral artery disease (PAD) is an increasing health problem with high mortality. Heart-type fatty acid-binding protein (H-FABP) and high-sensitivity troponin T (hsTnT) are markers of ongoing myocardial damage and have been reported to be useful indicators of future cardiovascular events. However, it remains to be determined whether H-FABP and hsTnT can predict adverse clinical outcomes in patients with PAD.Methods and resultsWe enrolled 208 de novo PAD patients who underwent EVT. Serum H-FABP and hsTnT were measured in all patients before EVT. During the median follow-up period of 694 days, there were 40 major adverse cardiovascular and cerebrovascular events (MACCEs) including all-cause deaths, and re-hospitalizations due to cardiovascular and cerebrovascular diseases and amputations. H-FABP and hsTnT were found to be higher in patients with critical limb ischemia (CLI) compared to those without this condition. Multivariate Cox proportional hazard regression analysis revealed that both H-FABP and hsTnT were independent predictors of MACCEs after adjustment for confounding factors. Kaplan–Meier analysis demonstrated that patients in the highest tertile according to H-FABP levels, as well as those in the highest hsTnT tertile, were at greatest risk for MACCEs. The net reclassification index was significantly improved by the addition of H-FABP as well as the addition of hsTnT to traditional risk factors.ConclusionThe myocardial damage markers H-FABP and hsTnT were increased in PAD patients with CLI and could predict MACCEs in PAD patients.

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Section: Introductionmentioning

confidence: 99%

Heart-type fatty acid binding protein and high-sensitivity troponin T are myocardial damage markers that could predict adverse clinical outcomes in patients with peripheral artery disease

et al. 2015

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“…In our study, when the concentration was normalized with urine protein both marker, FABP1 and FABP3 levels correlated the need of RRT in AKI patients irrespective of AKI cause. Elevated serum FABP1-levels have already shown to be prognostic in patients with sepsis [48] as well as in patients with acute heart failure/CHD [49,50] . They correlate with the allcause mortality in both conditions, whereas in acute heart failure, it can indicate the occurrence of AKI even on admission.…”

Section: Discussionmentioning

confidence: 99%

“…Despite elevated urinary levels of FABP1 in several conditions as sepsis and CHD/acute heart failure, and a higher prevalence of CHD and acute heart failure in the non-HD group or sepsis in the HD-group, respectively, urinary FABP1-levels were able to distinguish patients who are likely to need dialysis from those who do not. Otherwise, different medical situations, like sepsis, acute heart or liver failure, lead to an increase of serum FABP1 and/or FABP3 [48][49][50] . As both are small molecules, we cannot exclude the condition whether increased urinary levels derive from a spillover of these proteins and/or reduced tubular reabsorption.…”

Section: Discussionmentioning

confidence: 99%

FABP1 and FABP3 Have High Predictive Values for Renal Replacement Therapy in Patients with Acute Kidney Injury

Dihazi

Koziolek²,

Datta³

et al. 2016

Blood Purif

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Background/Aims: Early initiation of renal replacement therapy (RRT) is recommended in order to improve the clinical outcome of patients who develop an acute kidney injury (AKI). However, markers that guide an early RRT initiation do not really exist currently. Methods: Urine and serum samples were prospectively collected from 120 AKI patients. Depending on the necessity of initiating RRT, patients were divided into 2 different groups: dialysis (n = 52) and non-dialysis (n = 68). Results: Comparative urinary proteomic analyses identified 4 different proteins (fatty acid binding proteins 1 and 3 (FABP1 and FABP3), β-2-microglobulin (B2M), cystatin-M (CST6)) that discriminate AKI patients with high risk for RRT. Western blot analysis confirmed the proteomics data for FABP1 and FABP3 but not for B2M and CST6. Validation analysis confirmed that the FABP1 and FABP3 fulfilled the requirement of functioning as markers for AKI patients with risk to dialysis (p < 0.001). Conclusion: The release of high amounts of FABP1 and FABP3 in urine of AKI patients could serve as a diagnostic/prognosis marker for RRT initiation in these patients.

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“…Beberapa jam setelah infark miokard akut, H-FABP meningkat 18 kali lipat, sedangkan cTnT menanjak dua kali lipat dan mioglobin delapan kali lipat. 4,5,8 Ciri utama petanda ideal untuk deteksi dini cedera otot jantung meliputi: ukuran kecil: yaitu ukuran kecil petanda molekul lebih cepat dilepaskan ke dalam peredaran darah memungkinkan deteksi dini kerusakan otot jantung; ketidak-beradaan petanda dalam peredaran darah di bawah kondisi fisiologis, sehingga deteksi akan normal bahkan dengan kenaikan minimal petanda dalam plasma; kekhasan mutlak untuk otot jantung. Keuntungan H-FABP adalah dominan pada tahap awal infark miokard karena: ukuran dan berat molekul yang kecil, kepekatan yang melimpah di jaringan jantung, dilepaskan dan kinetika.…”

Section: -175unclassified

Heart Fatty Acid Binding Protein Sebagai Petanda Biologis Diagnosis Sindrom Koroner Akut

Puspitawati¹,

Sudana²,

Setyawati³

et al. 2018

Indonesian J. Clin. Pathol. Med. Lab.

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Heart-Fatty Acid-Binding Protein (H-FABP) is a membrane-bound protein that facilitates transport of fatty acids from the blood intothe heart. It is a low molecular weight cytoplasmic protein. Because of its small size and location, it is released rapidly into the bloodfollowing myocardial damage. The H-FABP levels rise as early as between 1−3 hours after the onset of Acute Coronary Syndrome, thepeak situation between 6−-8 hours, and returns to normal within 24 hours. The purpose of this study was to know the cut-off value ofHeart Fatty Acid Binding Protein with a sensitivity of at least 90% in patients with acute coronary syndrome in the Dr. Sardjito HospitalYogyakarta. The researchers undertook a cross sectional evaluation of 75 consecutive patients admitted with acute chest pain suggestiveof acute coronary syndrome (ACS). The H-FABP was measured by using immunoturbidimetry assay methods. The receiver operatingcharacteristic (ROC) analysis was calculated for the cut off point, sensitivity and specificity estimation. A total of 75 patients (59 in theACS group and 16 in the control group) were included in this study, and the majority of the ACS group (64 [76.2%]) were male patientswith AMI, 20 (26.7%) had an ST-elevation myocardial infarction and the rest (21 [28%]) had a non–ST-elevation myocardial infarction.The optimized cut-off obtained for h-FABP was 15 ng/mL, showing a sensitivity and specificity of the H-FABP assay for detecting ACSas 98.31 (95% CI 90 to 100) and 93.75% (95% CI 86 to 99), respectively. The areas under the receiver operator characteristic (ROC)curves to distinguish ACS from non-ACS were 0.983 (95% CI: 0.927– 0.999) for H-FABP. The optimized cut-off obtained for H-FABPwas 15 ng/mL, showing a 98.31% sensitivity and 93.75% specificity for detecting ACS in the Dr. Sardjito Hospital Yogyakarta.

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Elevated Serum Heart-Type Fatty Acid-Binding Protein in the Convalescent Stage Predicts Long-Term Outcome in Patients Surviving Acute Myocardial Infarction

Cited by 23 publications

References 28 publications

Heart-type fatty acid binding protein and high-sensitivity troponin T are myocardial damage markers that could predict adverse clinical outcomes in patients with peripheral artery disease

Heart-type fatty acid binding protein and high-sensitivity troponin T are myocardial damage markers that could predict adverse clinical outcomes in patients with peripheral artery disease

FABP1 and FABP3 Have High Predictive Values for Renal Replacement Therapy in Patients with Acute Kidney Injury

Heart Fatty Acid Binding Protein Sebagai Petanda Biologis Diagnosis Sindrom Koroner Akut

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