Serum ferritin level is higher in poorly controlled patients with Type 2 diabetes and people without diabetes, aged over 55 years

Abstract

Poorly controlled patients with type 2 diabetes and people without diabetes of over 55 years of age are likely to be at a higher risk of developing hyperferritinaemia. Thus, regular assessments of serum ferritin might be important for those who are at risk of hyperferritnaemia for prevention and an early intervention.

Circulating hepcidin in type 2 diabetes: A multivariate analysis and double blind evaluation of metformin effects

“…In our cross‐sectional study, 70% of individuals with type 2 diabetes had good diabetic control. Women with type 2 diabetes in our study tended to have higher iron stores, in agreement with those studies . Circulating hepcidin and sTfR seem to be more sensitive markers regarding changes in iron status even in well controlled diabetes.…”

“…Although most of the studies have reported higher serum ferritin in type 2 diabetes , Rajpathak et al. did not find this increase , and other authors found an increase in serum ferritin in women but not in men . In fact Batchuluun et al.…”

Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study

“…Serum ferritin is commonly used as a marker of iron stores, and a negative correlation between serum ferritin and insulin sensitivity has been reported [39]. Further, patients with DM are more prone to high concentrations of ferritin compared to patients without DM [39,40].…”

“…Further, patients with DM are more prone to high concentrations of ferritin compared to patients without DM [39,40]. This can be explained by the fact that iron metabolism is bidirectional, i.e., as iron affects glucose metabolism and glucose metabolism may also influence iron metabolism [41].…”

“…This can be explained by the fact that iron metabolism is bidirectional, i.e., as iron affects glucose metabolism and glucose metabolism may also influence iron metabolism [41]. In addition, iron stores may interfere with hepatic insulin extraction, leading to peripheral hyperinsulinemia [39]. Furthermore, data suggests that iron may catalyze the formation of reactive oxygen species, altering insulin sensitivity to its receptor and providing a pro-inflammatory state [42].…”