Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study

Paiva, Ana N.; Lima, Josivan Gomes de; Medeiros, Anna Cecília Queiroz de; Figueiredo, Heverton A.O.; Andrade, Raiana L. de; Ururahy, Marcela Abbott Galvão; Rezende, Adriana Augusto de; Brandão-Neto, José; Almeida, Maria das Graças

doi:10.1016/j.jtemb.2015.05.006

Cited by 57 publications

(15 citation statements)

References 31 publications

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“…Next, 172 titles and the abstracts were screened; of these, 47 publications were considered relevant and the full‐text articles were obtained. After careful assessment, a total of 28 RCTs that met our inclusion criteria were included in the present pooled analysis . Reasons for rejecting the other eight articles were listed in Supporting Information Fig.…”

Section: Resultsmentioning

confidence: 99%

Chromium supplementation for adjuvant treatment of type 2 diabetes mellitus: Results from a pooled analysis

Huang

Chen²,

Dong

et al. 2017

Molecular Nutrition Food Res

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Scope:We conducted a pooled analysis of randomized controlled trials to evaluate the effects of chromium supplementation on clinically relevant metabolic biomarkers in type 2 diabetes mellitus (T2DM) patients. Methods and results: Electronic searches were conducted and the bibliographies of located articles were searched, and 28 studies were suitable for statistical pooling. Endpoints were calculated as weighted mean differences (WMDs) with 95% confidence intervals (CIs) by using fixed-effects or random-effects models. Statistical heterogeneity, publication bias, subgroup analyses, sensitivity analysis and meta-regression assessments were also assessed. Chromium reduced levels of fasting plasma glucose (WMD, −0.99 mmol/L; 95% CI, −1.72 to −0.25; p = 0.008), hemoglobin A1c (WMD, −0.54 %; 95% CI, −0.82 to −0.25; p = 0.0002), triglycerides (WMD, −11.71 mg/dL; 95% CI, −18.38 to −5.04; p = 0.0006). Chromium also increased levels of high-density lipoprotein cholesterol (WMD, 1.73 mg/dL; 95% CI, 0.50 to 2.96; p = 0.006). These results were robust in sensitivity analysis and were not dependent on the chromium dose and duration of supplementation. Subgroup analyses indicated that these notably favorable effects were presented in T2DM subjects ingesting chromium chloride and chromium picolinate formulations. Conclusion: Our pooled analysis suggested that chromium supplementation might be a candidate as an adjunct to pharmacological management in patients with T2DM.

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Section: Resultsmentioning

confidence: 99%

Chromium supplementation for adjuvant treatment of type 2 diabetes mellitus: Results from a pooled analysis

Huang

Chen²,

Dong

et al. 2017

Molecular Nutrition Food Res

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“…The essentiality of Cr(III) and the use of it as supplement for glycemic control in type 2 diabetes is controversial [83]. Several clinical trials have evaluated the effect of chromium supplementation on glycemic control, with inconsistent findings [84–87]. Some studies have reported a potential role of Cr(III) in the maintenance of normal glucose tolerance through increasing the activity of insulin-stimulated tyrosine kinase [88].…”

Section: Current Perspectives and Resultsmentioning

confidence: 99%

Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium

Nigra

Ruiz-Hernandez

Redón

et al. 2016

Curr Envir Health Rpt

125

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Published systematic reviews concluded that there is moderate to strong evidence to infer a potential role of lead and cadmium, widespread metal exposures, as cardiovascular risk factors. For other non-essential metals, the evidence has not been appraised systematically. Our objective was to systematically review epidemiologic studies on the association between cardiovascular disease in adults and the environmental metals antimony, barium, chromium, nickel, tungsten, uranium, and vanadium. We identified a total of 4 articles on antimony, 1 on barium, 5 on chromium, 1 on nickel, 4 on tungsten, 1 on uranium and 0 on vanadium. We concluded that the current evidence is not sufficient to inform on the cardiovascular role of these metals because the small number of studies. Few experimental studies have also evaluated the role of these metals in cardiovascular outcomes. Additional epidemiologic and experimental studies, including prospective cohort studies, are needed to understand the role of metals, including exposure to metal mixtures, in cardiovascular disease development.

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“…In addition, supplement with Cr alter lipid and glucose metabolism [ 19 – 21 ], and growth performance in pigs [ 22 ]. Cr improved glucose tolerance [ 23 , 24 ], decreased total cholesterol and low-density lipoprotein levels [ 25 , 26 ]. The previous studies indicated that Cr alter lipid and glucose metabolism, but the underlying mechanism is unknown.…”

Section: Introductionmentioning

confidence: 99%

Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers

Chen

Gao

Chu

et al. 2018

Asian-Australas J Anim Sci

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ObjectiveThis experiment was conducted to investigate the effects of chromium picolinate (CrP) on fat deposition, genetic expression and enzymatic activity of lipid metabolism-related enzymes.MethodsTwo hundred forty one-day-old Ross broilers were randomly divided into 5 groups with 4 replicates per group and 12 Ross broiler chicks per replicate. The normal control group was fed a basal diet, and the other groups fed the same basal diet supplemented with 0.1, 0.2, 0.4, and 0.8 mg/kg CrP respectively. The experiment lasted for 21 days.ResultsAdded CrP in the basal diet decreased the abdominal fat, had no effects on subcutaneous fat thickness and inter-muscular fat width; 0.2 mg/kg CrP significantly decreased the fatty acid synthase (FAS) enzymatic (p<0.05); acetyl-CoA carboxylase (ACC) enzymatic activity decreased in all CrP groups (p<0.05); hormone-sensitive lipase (HSL) enzymatic activity also decreased, but the change was not significant (p>0.05); 0.4 mg/kg CrP group significantly decreased the lipoprotein lipase (LPL) enzymatic activity. FAS mRNA expression increased in all experimental groups, and the LPL mRNA expression significantly increased in all experimental groups (p<0.05), but not 0.2 mg/kg CrP group.ConclusionThe results indicated that adding CrP in basal diet decreased the abdominal fat percentage, had no effects on subcutaneous fat thickness and inter-muscular fat width, decreased the enzymatic activity of FAS, ACC, LPL and HSL and increased the genetic expression levels of FAS and LPL.

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Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study

Cited by 57 publications

References 31 publications

Chromium supplementation for adjuvant treatment of type 2 diabetes mellitus: Results from a pooled analysis

Chromium supplementation for adjuvant treatment of type 2 diabetes mellitus: Results from a pooled analysis

Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium

Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers

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