Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome

Elmas, Ahmet Taner; Tabel, Yılmaz; Elmas, Özlem

doi:10.1007/s00467-012-2331-5

Cited by 41 publications

(30 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elmas et al (24) found that serum cystatin C is an independent predictor of AKI in premature newborns with respiratory distress syndrome. Kandasamy et al (25) analyzed 10 studies that assessed the sensitivity of cystatin C as an early biomarker of AKI in neonates and found that it can be successfully used for evaluation of renal function in sick neonates (sepsis-induced AKI and congenital renal anomalies).…”

Section: Discussionmentioning

confidence: 99%

Early biomarkers of renal injury and protective effect of erythropoietin on kidneys of asphyxiated newborn rats

et al. 2014

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Early biomarkers of renal injury and protective effect of erythropoietin on kidneys of asphyxiated newborn rats

et al. 2014

View full text Add to dashboard Cite

“…In spite of recent advances in renal replacement therapies, mortality of AKI remains high (25% -78%) (2,6). It occurs in 44% -78% of patients with neonatal septicemia, and the risk is 2 -3 times higher in these patients, compared to those without AKI (3,14).…”

Section: Serum Phmentioning

confidence: 99%

“…Acute kidney injury (AKI) is a frequently encountered problem among ill neonates, admitted to neonatal intensive care units (8% -24%) (1,2). Decreased renal perfusion, low glomerular filtration rate, increased renal vascular resistance, and high plasma renin activity are major predisposing factors for acute renal impairment in the first days of life (3,4).…”

Section: Introductionmentioning

confidence: 99%

Predictive Factors for Acute Renal Failure in Neonates with Septicemia

Nickavar

Khosravi

Mazouri

2017

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Objectives: Septicemia is an important cause of acute kidney injury (AKI) in neonates admitted to neonatal intensive care units. The aim of this study was to identify the predictive factors for AKI in neonates with culture-proven septicemia.Methods: Medical records of 138 newborns with septicemia were evaluated in 2 groups with (n, 65) and without (n, 73) AKI. Results:The mean age at diagnosis of AKI was 11.31 ± 9.92 days. AKI was more common in neonates with lower gestational age, birth weight, age, blood pressure, platelet count, and serum pH at admission. Moreover, AKI was associated with an increased incidence of intubation at birth, inotrope treatment, shock, disseminated intravascular coagulation (DIC), mechanical ventilation, and morality. Gestational age, initial serum pH, and DIC were the only independent predictors of AKI in the multivariate analysis. In addition, serum pH at admission was the most accurate laboratory marker for the prediction of AKI with 83% sensitivity and 60% specificity. Conclusions:Monitoring of renal function is highly recommended in low-birth-weight infants with severe septicemia.

show abstract

“…Different studies correlated renal functional status using pRIFLE criteria with renal biomarker (uCysC and uIL-18) 19,20 . As this biomarker are not widely available and costly, this study correlated renal impairment using pRIFLE criteria with Apgar score in asphyxiated neonate , so that renal impairment can be predicted early by low Apgar score in perinatal asphyxia.…”

Section: Discussionmentioning

confidence: 99%

Renal Functional Status of Asphyxiated Babies & its Correlation with Apgar Score

Saha¹,

Mollah

Afroz

et al. 2017

J. Bangladesh Coll. Phys.

View full text Add to dashboard Cite

Introduction: Kidney is the 2nd commonest affected organ as a consequence of asphyxia1. Most attention is given to prevent CNS damage and neurological sequel but hypoxic renal insult not only influences neonatal morbidity & mortality but may give rise to CKD. to assess the renal functional status of asphyxiated babies.Material & Methods: This cross sectional study was conducted in the Department of Neonatology & Department of Gynecology and Obstetrics, Dhaka Medical College Hospital during January 2012 to January 2013. A total of 150 inborn, term asphyxiated neonates with e 2.5 kg who had history of delayed or no cry with Apgar score <7 at 5 minutes were enrolled. Then, the cases were grouped into mild (AS: 6-7), moderate (AS: 4-5) and severe asphyxia (AS: 0-3) based on Apgar score. Forty eight neonates were excluded according to exclusion criteria. Finally, the renal functions were assessed among 102 neonates by measuring urine output 8 hourly and estimated creatinine clearance (eCCL) on the 3rd day o7f life using Schwartz formula (eCCl=Height (cm) ×.37/S.creatinine). Neonates with impaired renal function were further classified as stage-I (risk), II (injury), III (failure) using pRIFLE criteria. Data were analyzed by Chi-square & Pearson correlation coefficient test to find out correlation between Apgar scores and renal functional status.Results: Of the 102 cases studied, majority 48% were in moderate, 30.4% in mild and 21.6% in severely asphyxiated group. In the mild asphyxiated group 58.06% had normal renal function. However, the remaining cases 29.03% & 12.90% had stage I, stage II renal injury respectively and had no renal failure. In Moderately asphyxiated group, 26.53% had normal renal function & the remaining 32.65%, 34.69%, 6.1% had stage I, II, III renal injury respectively. None of the severely asphyxiated babies had normal renal function. However they had impaired renal function ranging from Stage I (27.27%), stage II (27.27%) & stage III (40.90%).Variable proportion of kidney injuries were noted among the asphyxiated neonates. The lower the Apgar score, the more severe the injuries and association between stages of kidney injuries and Apgar score was observed statistically significant (p<0.001). The renal functional status (eCCL) was also found positively correlated with low Apgar score (r=0.6, p<0.002).Conclusion: Variable functional impairment of kidneys was found among the asphyxiated neonates and the severity of impairment significantly correlated with low Apgar score.J Bangladesh Coll Phys Surg 2017; 35(3): 128-132

show abstract

Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome

Abstract: sCysC is an independent predictor of AKI in preterm neonates with RDS.

Cited by 41 publications

References 38 publications

Early biomarkers of renal injury and protective effect of erythropoietin on kidneys of asphyxiated newborn rats

Early biomarkers of renal injury and protective effect of erythropoietin on kidneys of asphyxiated newborn rats

Predictive Factors for Acute Renal Failure in Neonates with Septicemia

Renal Functional Status of Asphyxiated Babies & its Correlation with Apgar Score

Contact Info

Product

Resources

About