Serum CRP Concentrations and Severity of Ischemic Stroke Subtypes

Luo, Yumin; Wang, Zhongyuan; Li, Jingwei; Xu, Yun

doi:10.1017/s0317167100012713

Cited by 34 publications

(28 citation statements)

References 22 publications

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“…Furthermore, serum miR-146b was strong positive correlated with both infarct volume and NIHSS score. It has been reported that elevated plasma hs-CRP level was positively correlated with infarct volume and NIHSS score [25,26], thus, serum miR-146b correlated with plasma hs-CRP also can reflect the severity of acute ischemic stroke and might be useful as a clinical tool for predicting outcome.…”

Section: Discussionmentioning

confidence: 99%

Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke

Chen

Wang

Huang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Stroke is a major cerebrovascular disease threatening human health and life with high morbidity, disability and mortality. It is aimed to find effective biomarkers for the early diagnosis on stroke. Methods: The expressions of 17 previously reported strokeassociated miRNAs were measured using quantitative RT-PCR and the expressions of plasma high-sensitivity C reactive protein (hs-CRP) and serum interleukin 6 (IL-6), the proinflammation markers in brain injury, were examined using enzyme-linked immunosorbent assay in 128 acute ischemic stroke (AIS) patients and control group.

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Section: Discussionmentioning

confidence: 99%

Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke

Chen

Wang

Huang

et al. 2018

Cell Physiol Biochem

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“…Higher NIHSS rate will result in severer disease and higher level of hs-CRP, indicating that the increase in hs-CRP level is closely associated with the severity of disease, which is similar with the point proposed by literatures. [7,8] It is analyzed that larger volume of infarction will result in severer neurological impairment degree, symptoms and local or systemic inflammatory responses, and stimulate hepatic cells to generate more hs-CRP.…”

Section: Discussionmentioning

confidence: 99%

A study on the relationship between changes in serum hs-CRP levels and Chinese ischemic stroke subclassification

Li-h

2018

DCC

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Objective: To study the relationship between changes in serum high sensitivity C-reactive protein (hs-CRP) levels and Chinese ischemic stroke subclassification (CISS), and explore the action mechanism of hs-CRP in the pathogenetic process of ischemic stroke. Methods: The serum hs-CRP level was measured in all subjects (including the healthy). As to 177 ischemic stroke patients, they were subclassified based on causes and pathogenesis to explore the relationship between the serum hs-CRP level and CISS. Results: The serum hs-CRP level in the ischemic stroke group was significantly higher than that in the control group (p < .05). The difference of the serum hs-CRP levels in different Chinese ischemic stroke subtypes was of statistical significance (p < .05). Conclusions: The level of serum hs-CRP is closely associated with the incidence of the ischemic stroke, and the difference of the serum hs-CRP levels in different Chinese ischemic stroke subtypes is of statistical significance.Key Words: High sensitivity C-reactive protein, Ischemic stroke, Chinese ischemic stroke subclassification High sensitivity C-reactive protein (hs-CRP), a proinflammatory factor related to the occurrence and development of atherosclerosis, plays an important role in the pathological mechanism of cerebral stroke. Cerebral strokes resulted from different causes show different clinical manifestations with treatment methods and prognosis differed. Therefore, the study on cerebral stroke subtypes is increasingly valued. Recently, Gao S et al. [1] have proposed that, Chinese ischemic stroke subclassification (CISS) is a new stroke subclassification based on causes and pathogenesis and is widely used in clinical practice. With the application of CISS standards, this study is intended to observe and analyze the relationship between the level of hs-CRP and CISS, in order to provide an evidence for the diagnosis and treatment of ischemic strokes with different causes and pathogenesis.

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“…This enzyme cleaves a wide diversity of substrates, includ- Stroke is a heterogeneous phenotype, and therefore an analysis of the incidence of stroke may overlook genetic effects that are restricted to a certain stroke subtypes. OCSP is a clinical classification that provides information regarding the extent of the lesion 21) . Bamford et al reported that, in their study, the patients in the PACI group were much more likely to have episodes of early recurrent stroke than the patients in other groups 13) .…”

Section: Effects Of Adam17 Gene Polymorphisms On the Adam17 Expressionmentioning

confidence: 99%

Association between ADAM17 Promoter Polymorphisms and Ischemic Stroke in a Chinese Population

Cui

et al. 2014

JAT

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Aim: Stroke is a leading cause of death and disability worldwide. Most ischemic strokes (IS) are caused by atherosclerosis. Recently, the pivotal role of ADAM17 in atherosclerosis has been thoroughly addressed. However, the association between ADAM17 and IS has not yet been thoroughly explored. The present study therefore aimed to investigate the association between disintegrin and metalloproteinase 17 (ADAM17) gene polymorphisms and the risk of ischemic stroke (IS). Methods: The associations between five ADAM17 promoter polymorphisms and the risk of IS were assessed in 342 patients with IS and 296 age-matched healthy individuals in a case-control study. Results: The allele and genotype frequencies of the ADAM17 polymorphisms (rs11684747, rs11689958, rs12692386, rs55790676 and rs1524668) did not differ significantly between the IS patients and healthy control group subjects. In addition, no significant associations were detected between the ADAM17 haplotypes and IS. The mean intima-media thickness in the IS patients was not associated with the ADAM17 polymorphisms. When the IS patients were stratified according to their OCSP classification, the genotype frequencies of the ADAM17-rs1524668 polymorphism exhibited a significant association with the PACI subtype of IS. Moreover, the ADAM17-rs12692386 A＞G polymorphism was found to be associated with a higher ADAM17 mRNA expression. Conclusions: The SNPs in the ADAM17 promoter region do not appear to be major contributors to the pathogenesis of IS. However, the rs12692386 G ADAM17 allele is correlated with a higher expression of ADAM17 mRNA, which may play a role in increasing inflammation in IS patients. Furthermore, the ADAM17-rs1524668 polymorphism is linked to a higher risk of PACI-type stroke, confirming the role of ADAM17 in the pathophysiology of PACI, with potentially important therapeutic implications. and the third most common cause of death in many developed and developing countries. Approximately 80% of stroke cases involve ischemic stroke (IS) 1) , which is primarily caused by atherosclerosis, a chronic inflammatory disease of the vessel wall 2) . ADAM (a disintegrin and metalloproteinase) genes, which are characterized by their metalloproteinase domain and disintegrin-cysteine rich region, are essential for a number of biological processes, including inflammation, cell proliferation and migration, immunity and You Li and Li-Li Cui contributed equally to this work. 879 ADAM17 Polymorphisms and Ischemic Stroke Materials and Methods SubjectsA total of 342 ischemic stroke patients (mean age, 70.30±10.75 years) were recruited from the First Affiliated Hospital of Guangdong Medical College between 2012 and 2013. An IS diagnosis was established based on the patient's clinical signs and symptoms. All patients underwent computed tomography (CT) scans and/or magnetic resonance imaging (MRI) as well as standardized blood tests. Based on the clinical manifestations and neuroimaging data, two neurologists classified the ischemic strokes into four subtypes using eithe...

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Serum CRP Concentrations and Severity of Ischemic Stroke Subtypes

Cited by 34 publications

References 22 publications

Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke

Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke

A study on the relationship between changes in serum hs-CRP levels and Chinese ischemic stroke subclassification

Association between ADAM17 Promoter Polymorphisms and Ischemic Stroke in a Chinese Population

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