A study on the relationship between changes in serum hs-CRP levels and Chinese ischemic stroke subclassification

Abstract

Objective: To study the relationship between changes in serum high sensitivity C-reactive protein (hs-CRP) levels and Chinese ischemic stroke subclassification (CISS), and explore the action mechanism of hs-CRP in the pathogenetic process of ischemic stroke. Methods: The serum hs-CRP level was measured in all subjects (including the healthy). As to 177 ischemic stroke patients, they were subclassified based on causes and pathogenesis to explore the relationship between the serum hs-CRP level and CISS. Results: The serum hs-CRP level in the ischemic stroke group was significantly higher than that in the control group (p < .05). The difference of the serum hs-CRP levels in different Chinese ischemic stroke subtypes was of statistical significance (p < .05). Conclusions: The level of serum hs-CRP is closely associated with the incidence of the ischemic stroke, and the difference of the serum hs-CRP levels in different Chinese ischemic stroke subtypes is of statistical significance.Key Words: High sensitivity C-reactive protein, Ischemic stroke, Chinese ischemic stroke subclassification High sensitivity C-reactive protein (hs-CRP), a proinflammatory factor related to the occurrence and development of atherosclerosis, plays an important role in the pathological mechanism of cerebral stroke. Cerebral strokes resulted from different causes show different clinical manifestations with treatment methods and prognosis differed. Therefore, the study on cerebral stroke subtypes is increasingly valued. Recently, Gao S et al. [1] have proposed that, Chinese ischemic stroke subclassification (CISS) is a new stroke subclassification based on causes and pathogenesis and is widely used in clinical practice. With the application of CISS standards, this study is intended to observe and analyze the relationship between the level of hs-CRP and CISS, in order to provide an evidence for the diagnosis and treatment of ischemic strokes with different causes and pathogenesis.