Serum copper and its relationship to clinical symptoms in rheumatoid arthritis.

Brown, D. H.; Buchanan, W. Watson; El‐Ghobarey, A. F.; Smith, W. Ewen; Teape, J.W.

doi:10.1136/ard.38.2.174

Cited by 35 publications

(10 citation statements)

References 7 publications

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“…Several authors have reported diminished levels of copper during this treatment (Scudder et al, 1978a;Brown et al, 1979). The decrease of serum copper could be due to the use of corticosteroids, explaining the similar copper levels found in patients not using corticosteroid therapy.…”

Section: Serum Coppermentioning

confidence: 59%

Copper and zinc intake and serum levels in patients with juvenile rheumatoid arthritis

et al. 2003

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Objective: To evaluate the copper and zinc intake and serum levels in patients with juvenile rheumatoid arthritis (JRA), considering the pauci and polyarticular types, the disease activity and duration, the number of inflamed joints and the use of corticosteroids therapy. Design: Cross-sectional study with control group. Setting: Outpatients of the pediatric rheumatology public health clinic, of the Universidade Federal de São Paulo=Escola Paulista de Medicina, Brazil. Subjects: Forty-one patients with JRA were evaluated and 23 patients' brothers, as a control group. Interventions: Copper and zinc intake evaluation by Food Register method. Copper and zinc serum levels by atomic absorption spectrophotometry. Results: The disease activity did not determine difference in copper (P ¼ 0.624) and zinc (P ¼ 0.705) intake, being predominantly below the Recommended Dietary Allowances. The serum copper in relation to control was statistically greater (P ¼ 0.018), showing that the number of inflamed joints is statistically significantly related with its variation (P ¼ 0.001). The serum zinc was not different either in relation to control (P ¼ 0.940) or to the disease characteristics. Conclusions: The evaluation of copper intake seems to be of fundamental importance. It may influence the efficiency of the organic serum response. More research is needed to indicate, with security, adequate zinc intake.

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Section: Serum Coppermentioning

confidence: 59%

Copper and zinc intake and serum levels in patients with juvenile rheumatoid arthritis

et al. 2003

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“…17 pmol/1) in R A patients compared with con trols. Raised serum Cu++ levels have also been reported [2,5,7,22], Aaseth et al [2] suggested that elevated Cu++ levels in RA might assist progression of the disease by causing tissue damage through reduction of membrane sta bility. On the other hand, copper complexes have been claimed to be efficacious in the treatment of arthritic conditions [23], How ever, no sufficient explanation for these bene ficial effects of copper has been proposed.…”

Section: Discussionmentioning

confidence: 92%

Influence of Zinc and Copper on Lapine Articular Chondrocytes in Monolayer Culture

Kirkpatrick

Mohr

Haferkamp³

1982

Pathobiology

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The effects of zinc and copper ions on the structure, proliferative capacity and proteoglycan metabolism of lapine articular chondrocytes were studied in a monolayer culture system. Zn⁺⁺ was cytotoxic at a concentration of 100µmol/l, whereas 50 µmol/l caused a stimulation of chondrocyte proliferation with simultaneous reduction (p& < 0.01) in macro-molecular binding of ³⁵SO₄. 10 µmol/l Zn⁺⁺ failed to evoke any alteration in these parameters. Cu⁺⁺ concentrations of 100 and 50 µmol/l significantly reduced cell proliferation (p& < 0.01) with a concomitant stimulation of ³⁵SO₄ uptake into pro teogly cans. 10 µmol/l Cu⁺⁺ did not significantly alter chondrocyte multiplication nor binding of ³⁵SO₄ It is proposed that Zn⁺⁺ may play a role in chondrocyte damage in joint disease. Furthermore, the possible therapeutic efficacy of copper in maintaining cartilage integrity is supported.

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“…Increased serum copper level has been found in rheumatoid arthritis (31) and in adjuvant arthritic rats (32), providing defini tive evidence for the involvement of endoge nous copper in inflammatory disease. In this experiment, adjuvant arthritic rats also showed a marked increase in serum copper level, while cholesterol-fed rats tended to have higher levels.…”

Section: Discussionmentioning

confidence: 99%

Suppression of Adjuvant Arthritis in Rats by Cholesterol

Kunitomo

Yamaguchi

Futagawa

et al. 1987

Japanese Journal of Pharmacology

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Abstract-Dietary cholesterol suppressed adjuvant arthritis, a chronic inflammatory disease, in rats, but did not significantly affect carrageenin edema, an acute inflammation.When rats were fed a high-cholesterol diet beginning 10 days before injection of adjuvant, the development of the adjuvant-induced arthritis was greatly suppressed.Cholesterol feeding prevented hypertrophy of the adrenal gland in arthritic rats, but had little influence on the serum corticosterone level. A sig nificant positive correlation was observed between the adrenal weight and the severity of the arthritis.These findings suggest that the effect of cholesterol feeding is not due to increased adrenal sterol synthesis.Dietary cholesterol also prevented hypertrophy of the spleen, but had no effect on atrophy of the thymus in adjuvant treated rats. Cholesterol-fed rats showed a significant decrease in the serum lipid peroxide level and a significant increase in the serum copper level. Adjuvant treatment not only enhanced hypercholesterolemia produced by cholesterol feeding, but also the level of free cholesterol in serum. These results suggest that dietary cholesterol may exert some effect on the immune response through changes in spleen and liver functions.

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Serum copper and its relationship to clinical symptoms in rheumatoid arthritis.

Cited by 35 publications

References 7 publications

Copper and zinc intake and serum levels in patients with juvenile rheumatoid arthritis

Copper and zinc intake and serum levels in patients with juvenile rheumatoid arthritis

Influence of Zinc and Copper on Lapine Articular Chondrocytes in Monolayer Culture

Suppression of Adjuvant Arthritis in Rats by Cholesterol

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