Serum copeptin in children exposed to maltreatment

Abstract

CM is associated with copeptin serum levels independently of age, sex, and symptom severity. Copeptin is a promising new biomarker for children with a history of abuse and/or neglect.

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

“…In a further study, induction of panic symptoms in 30 healthy male human subjects by intravenous cholecystokinin-tetra peptide, a substance well known to induce panic symptoms and activate the pituitary-adrenal axis activity, resulted in substantial increases in circulating concentrations of copeptin and cortisol [37]. Further, children exposed to maltreatment, such as physical abuse, neglect, emotional maltreatment and sexual abuse, and individuals with suicidal behaviour have higher circulating copeptin concentrations [10,13]. Finally, although depressed ambulatory patients, participating in an exercise study, had similar plasma copeptin concentrations to controls [36], among individuals attempting suicide, circulating copeptin concentrations, measured within the first hour of patient admission, were strongly correlated with both depression scores (r=0.63, P<0.001) [13] and anxiety scores (r=0.76, P<0.001) [13].…”

“…The notion that mental stress leads to higher circulating copeptin concentrations is supported by the medical literature, which also suggests the AVP-stimulated increased pituitaryadrenal axis activity could be involved [8]. In one study, 25 medical students were tested immediately prior to a written examination and after its conclusion [10] Comparing before and after, the students had higher heart rate, reported a higher stress level, and had higher serum concentrations of copeptin and cortisol after the study [10]. In another study, 20 healthy adults underwent the Trier Social Stress Test [11].…”

“…Psychological stress, for example related to childhood maltreatment, written exams and social stress tests, as well as stressful mental states, such as suicidal behaviour, have been associated with higher circulating copeptin concentrations [10][11][12][13]. This suggests that an increased AVP secretion, because of stressful mental brain activity, could be involved in the development of IR and the metabolic abnormalities related to IR [14][15][16].…”

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surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress. Peptides, 115,[8][9][10][11][12][13][14] Dette er siste tekst-versjon av artikkelen, og den kan inneholde små forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du her: http://dx.

ABSTRACTIn middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR).

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Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder

“…In fact, evidence has indicated that plasma copeptin levels are associated with psychosocial stress and HPA axis activation, without the main limitation of saliva cortisol measurements, such as the estimation of HPA activation only in a short time before assessment. In fact, copeptin levels seem to be altered even several months or years after the stressor . Although peripheral copeptin has been considered a promising biomarker, it was never measured in individuals with BD.…”