Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

Abstract

surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress. Peptides, 115,[8][9][10][11][12][13][14] Dette er siste tekst-versjon av artikkelen, og den kan inneholde små forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du her: http://dx. ABSTRACTIn middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95% confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were logtransformed. Among the young adults, copeptin associated with IR (B (95%CI) =0.19 (0.11 to 0.27), P<0.001). This association was not found among the adolescents (B=-0.01 (-0.12 to 0.09), P=0.78). MDI score associated with IR (B=0.010 (0.004 to 0.016), P<0.001) and copeptin (B=0.010 (0.004 to 0.015); P<0.002) in the young adults. Adjusted for copeptin, the strength of the association between MDI score and IR somewhat diminished (to B=0.008). In conclusion, adolescence and psychological stress appear to influence the association between copeptin and IR.

No association between major depression with and without childhood adversity and the stress hormone copeptin

“…Our all-female sample was different to the mixed samples investigated by Thomsen et al ( 2019 ) and Coelho et al ( 2016 ). Not only basal copeptin concentrations (Burckhardt et al, 2014 ) but also the effects of stress on copeptin levels (Spanakis et al, 2016 ) seem to be sex-specific and thus are different in males and females.…”

“…Major depressive disorder (MDD) and adverse childhood experiences (ACE) such as abuse and neglect have complex und unfavourable long-term effects on both mental and physical health (Otte et al, 2016 ), which might be partially explained by HPA axis dysfunction (De Bellis & Zisk, 2014 ). Depressive symptoms were associated with copeptin plasma concentrations in young adults (mean age: 24.3 ± 2.97 years; female: 52.4%), with no differences between men and women (Thomsen et al, 2019 ). In another study, plasma copeptin concentrations were not significantly different between depressed subjects (mean age: 41.9 ± 11.2 years; female: 68.2%) and healthy controls (mean age: 40.6 ± 13.1 years; female: 64.9%), and no association was observed between copeptin and cortisol or ACTH (Krogh et al, 2013 ).…”

“…Coelho et al, 2016 ) or young adults (e.g. Thomsen et al, 2019 ), we opted for adult women in order to extend the literature in this population, since ACE has repeatedly been associated with mental impairments and disorders in later life (Gould et al, 2012 ; Kaczmarczyk, Wingenfeld, Kuehl, Otte, & Hinkelmann, 2018 ; Majer, Nater, Lin, Capuron, & Reeves, 2010 ; Pechtel & Pizzagalli, 2011 ). We hypothesized that plasma levels of copeptin would be positively correlated with MDD and ACE.…”

Copeptin in anorexia nervosa

“…Different subtypes of ADH receptors have been detected not only in the hypothalamus, but also in the cerebral cortex and the hippocampus where it may be involved in responses to stress, depression, and anxiety (Rutigliano et al, ). Depression and anxiety have been reported to be associated with elevated levels of ADH (Csikota et al, ) and copeptin (Thomsen et al, ) in several different settings such as childhood maltreatment and suicidal behavior.…”

“…Copeptin measurement in plasma was initially thought of as a sensitive marker in the diagnosis of diabetes insipidus, where the plasma concentrations are markedly reduced. However, copeptin has also been associated with common cardiometabolic disease, namely insulin resistance, diabetes, and heart failure (Alehagen, Dahlstrom, Rehfeld, & Goetze, ; Enhorning et al, ; Thomsen et al, ). Psychological stress is associated with increased levels of cortisol and insulin resistance, and there is evidence that increased ADH secretion may be a link between stress, insulin resistance, and cardiovascular morbidity (Thomsen et al, ).…”