Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome

Adamska, Agnieszka; Łebkowska, Agnieszka; Jacewicz, Malgorzata; Krentowska, Anna; Hryniewicka, Justyna; Wołczyński, Sławomir; Górska, Maria; Kowalska, Irina

doi:10.1155/2017/2316986

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…Although circulating ANGPTL8 levels have been reported to be related to IR [26], T2DM [27–30], obesity [27, 30], PCOS [31–33], nonalcoholic fatty liver disease (NAFLD) [34], and MetS [12, 35], ANGPTL8 is mainly secreted and expressed by hepatocytes. It reduces the cleavage of triglycerides by inhibiting the activity of lipoprotein esterase and increases the level of triglycerides.…”

Section: Discussionmentioning

confidence: 99%

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Yin³

et al. 2019

Mediators of Inflammation

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Background. ANGPTL8 has been reported to be a regulator of lipid metabolism, and it is associated with insulin resistance (IR) and metabolic syndrome (MetS). We investigated whether ANGPTL8 plays a role in MetS. Methods. ANGPTL8 and adiponectin concentrations were measured in PCOS patients with or without MetS and in their corresponding healthy controls. The association of circulating ANGPTL8 with adiponectin and other parameters was also examined. Results. Circulating ANGPTL8 concentrations were higher in PCOS women with MetS than in those without MetS and in the controls (P<0.01). ANGPTL8 was positively correlated with age, BMI, FAT%, WHR, SBP, TG, FBG, HbA1c, Fins, and HOMA-IR (all P<0.01) in the study populations and negatively associated with adiponectin and M-values (P<0.001). In addition, ANGPTL8 was positively correlated with PRL, LH, TEST, and FAI and negatively correlated with SHBG (all P<0.01). ROC curve analyses showed that the AUCMetS was 0.87 (P<0.001), with a sensitivity of 92.4% and specificity of 75.4%, and the AUCIR was 0.82 (P<0.01), with a sensitivity of 76.4% and specificity of 75.6%. Conclusion. ANGPTL8 levels progressively decrease from PCOS patients with MetS to those without MetS and may be a serum marker associated with the degree of metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Yin³

et al. 2019

Mediators of Inflammation

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“…Very recently, Calan et al have reported that betatrophin levels were increased in PCOS women and were associated with HOMA-IR, high-sensitivity C-reactive protein (hs-CRP), and free-testosterone [ 19 ]. In addition, another study also found that circulating betatrophin was associated with IR in PCOS women [ 20 ]. Based upon the data from recent reports and our present study, it is reasonable to speculate that betatrophin may contribute to the development of chronic inflammation and IR.…”

Section: Discussionmentioning

confidence: 99%

Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studiesin vivoandin vitro

Wang

et al. 2017

Oncotarget

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Betatrophin has a closely relationship with metabolism. However, its effect on metabolism disorder remains unclear. This study was comprised of a series of cross-sectional and interventional studies in vivo and vitro. PCOS women with IR and healthy women were recruited from the general population and outpatients. Plasma betatrophin levels were measured with ELISA. Insulin sensitivity was assessed with EHC. Gene expressions at mRNA and protein levels were determined with RT-PCR and Western blotting. Influences of insulin, metformin, rosiglitazone and over- or knockdown-expression of betatrophin were analyzed ex vivo. Our results indicated that IR women had higher betatrophin levels compared with the controls. Circulating betatrophin was positively correlated with BMI, WHR, Fat%, triglyceride, total cholesterol, LDL-C, AUCglucose and AUCinsulin, luteinizing Hormone, FAI and HOMA-IR but negatively with M-value. Metformin treatment in PCOS women with IR led to a reduction of betatrophin levels. Insulin stimulation in hepatocytes increased betatrophin expression. Metformin or rosiglitazone led to a reduction of betatrophin expression in insulin-stimulated hepatocytes. In hepatocytes/macrophages co-culture systems, betatrophin expression was significantly increased, whereas this increase was eliminated by rosiglitazone. In hepatocytes, overexpression and knockdown of betatrophin decreased or increased insulin-stimulated insulin receptor, protein kinase B and insulin receptor substrate-1 phosphorylation respectively. Serum from metformin-treated women with IR decreased betatrophin expression and reinforced insulin signals. Thus, the present study provides the in vivo and in vitro evidence, suggesting that there is a cell cross-talking between hepatocytes with macrophages for the regulating betatrophin and it may be a useful marker for IR and metabolic disorders.

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“…A subsequent study by the same research team found that betatrophin concentrations were not associated with C-peptide levels in patients with T2DM, whereas in non-diabetic individuals a positive relationship between betatrophin and C-peptide concentrations was established [9]. An association between betatrophin, insulin resistance and beta cell function has been observed in other diseases such as polycystic ovary syndrome [10].…”

Section: Introductionmentioning

confidence: 95%

Wyższe stężenie betatrofiny u pacjentów z noworozpoznaną cukrzycą

Maciulewski

Zielinska–Maciulewska

Siewko

et al. 2019

Clinical Diabetology

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Introduction. Betatrophin is primarily produced in the liver and regulates the metabolism of triglycerides. Its elevated concentration might be associated with an increased risk of type 2 diabetes. The aim of the study was to evaluate the impact of betatrophin on beta cell function and to compare the concentration of betatrophin in patients newly diagnosed with type 1 diabetes mellitus (T1DM including LADA), type 2 diabetes mellitus (T2DM) and a control group (CG) of healthy volunteers. Patients and methods. The study included 210 patients with newly diagnosed diabetes (70 with T1DM, 140 with T2DM) and 70 CG. To evaluate the relationship between betatrophin and insulin secretion, a glucagon stimulation test was conducted. Results. Serum betatrophin concentrations were significantly elevated in T1DM and T2DM in comparison to the control group (3.47 [Q 1 = 2.28, Q 3 = 4.54] in T1DM vs. 1.81 [Q 1 = 1.04, Q 3 = 2.67] ng/ml in CG, p < 0.001; 3.12 [Q 1 = 1.89, Q 3 = 4.48] in T2DM vs. 1.81 [Q 1 = 1.04, Q 3 = 2.67] ng/ml in CG, p < 0.001). No statistically significant differences in betatrophin concentration were observed between the T1DM and T2DM groups. Significant correlations were established between betatrophin, triglyceride (TG) and high-density lipoprotein (HDL) levels in all study participants, and C-peptide in the T1DM group. Conclusions. Betatrophin concentration was significantly elevated in patients with newly diagnosed T1DM and T2DM, compared to the control group and could be a biomarker of diabetes. Our study provided evidence which supports the impact of betatrophin on lipid metabolism. The positive correlation between betatrophin and C-peptide in the T1DM group suggests that betatrophin is associated with insulin secretion in

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Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome

Cited by 9 publications

References 36 publications

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studiesin vivoandin vitro

Wyższe stężenie betatrofiny u pacjentów z noworozpoznaną cukrzycą

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