Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Pu, Danlan; Li, Ling; Yin, Jun; Li, Rui; Yang, Gangyi; Liao, Yong; Wu, Qinan

doi:10.1155/2019/6321427

Cited by 13 publications

(13 citation statements)

References 42 publications

(54 reference statements)

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“…In the correlation analysis performed betatrophin levels showed positive correlations with BMI, FPG, insulin, HOMA-IR, TC, TAG, LDL-C, LH and TT in obese and non-obese PCOS patients. This finding was consistent with the Pu et al [8], Luo et al [10], Qu et al [15], Sahin et al [1] and Duan et al [12]. A strongly positive correlation was found between circulating betatrophin levels and LH, free-testosterone, HOMA-IR, BMI, insulin, FBG, and lipid profile (triglycerides, LDL-C, and total cholesterol) in both groups Calan et al [16].…”

Section: Fig 4 Correlation Between Betatrophin and Wisp1 Non-obese supporting

confidence: 90%

“…The mechanism underlying the association between betatrophin and LH may be related to the signaling pathways between pituitary and liver, which may result in the stimulation of betatrophin by LH as a pituitary hormone. Conversely Wang et al [13] and Pu et al [8] founded that there were significant negative correlation between betatrophin level and insulin, HOMA-IR and BMI. These contradicting results may be due to differences in methodology, study design, participants, and sample sizes Varikasuvu et al [11].…”

Section: Fig 4 Correlation Between Betatrophin and Wisp1 Non-obese mentioning

confidence: 95%

“…Betatrophin identified as secretory protein secreted mainly by hepatocytes with a potential role in lipid metabolism by regulating the level of plasma triglycerides and cholesterol through inhibition of lipoprotein lipase (LPL) [7]. Betatrophin has been reported to be a regulator of lipid metabolism and overexpression of betatrophin may reduce insulin sensitivity, and enhance IR in hepatocytes [8].…”

Section: Introductionmentioning

confidence: 99%

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A Potential Pathological Role of Wingless Type1 Inducible Signaling Pathway Protein-1 and Betatrophin in Obese Women with Polyststic Ovary Syndrome

Hassan

Mohammed

Abdelatif

et al. 2020

AJBGMB

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Background: Polycystic Ovary Syndrome is a common female endocrinopathy. It is associated with adipokines dysfunctional secretion pattern and insulin resistance, which is considered as the main reason for its clinical feature. Wingless type1 inducible signaling pathway protein-1 is a novel adipokine that displays insulin resistance and adipose tissue inflammation where it strongly related to adipocyte accumulation and regeneration. Betatrophin has a potential role in pancreatic beta-cell proliferation and obesity and several studies showed inconsistent betatrophin levels in patients with diabetes and obesity but, its relation to polycystic ovary syndrome is unclear. Aim: Investigation of the role of serum wingless type1 inducible signaling pathway protein-1 and betatrophin in normal weight and obese patients with polycystic ovary syndrome. Studying their association with other markers, then determine whether obesity and insulin resistance is associated with them. Methods: Wingless type1 inducible signaling pathway protein-1 and betatrophin serum levels were measured in 44 patients with polycystic ovary syndrome (22 obese and 22 non-obese) and 44 matched control (22 obese and 22 non-obese) females using specific ELISA kits. Results: Betatrophin and wingless type1 inducible signaling pathway protein-1 levels were elevated in the polycystic ovary syndrome group (49.4 pg/ml, 187.6 pg/ml) than in the control group (32.08 pg/ml, 108.4 pg/ml) respectively. Moreover, their levels were higher in the obese subgroup than in normal weight subgroup. There were positive correlations between wingless type1 inducible signaling pathway protein-1 and betatrophin in non-obese (r=0.89, p=0.0001***) and in obese (r=0.78, p=0.0001***) polycystic ovary syndrome groups. Conclusion: Betatrophin and wingless type1 inducible signaling pathway protein-1 are associated with adiposity and insulin resistance in polycystic ovary syndrome. Hence wingless type1 inducible signaling pathway protein-1 and betatrophin may play a role in the incidence of polycystic ovary syndrome. They may be valuable in diagnosis and prediction of polycystic ovary syndrome patients.

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Section: Fig 4 Correlation Between Betatrophin and Wisp1 Non-obese supporting

confidence: 90%

Section: Fig 4 Correlation Between Betatrophin and Wisp1 Non-obese mentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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A Potential Pathological Role of Wingless Type1 Inducible Signaling Pathway Protein-1 and Betatrophin in Obese Women with Polyststic Ovary Syndrome

Hassan

Mohammed

Abdelatif

et al. 2020

AJBGMB

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“…Irisin is a myokine and expressed in muscle as the type I membrane precursor protein FNDC5, which is proteolytically cleaved, secreted into the circulatory system, and found to improve muscle IR [17]. These cytokines are also believed to be involved in metabolic diseases, such as T2DM, PCOS, and MetS [13,[18][19]. However, a single cytokine can not reflect the whole pathological process, but only one aspect of disease development.…”

Section: Introductionmentioning

confidence: 99%

Association of metabolic syndrome components with circulating levels of cytokine clusters in young women

Tan

Hu²,

Yang

et al. 2021

Endocrine Connections

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Background: The purpose of this study was to investigate the relationship between circulating zinc α 2-glycoprotein (ZAG), Irisin, betatrophin and adiponectin concentrations and metabolic syndrome (MetS) components and to analyze the effects of blood glucose and insulin on these cytokine concentrations in vivo. Methods: A total of 196 young women, including 78 healthy women and 118 women with MetS components, were recruited for this cross-sectional study. An oral glucose tolerance test and euglycemic-hyperinsulinemic clamp (EHC) were performed in healthy subjects and women with MetS components. An enzyme-linked immunosorbent assay kit was used to measure serum ZAG, irisin, betatrophin, and adiponectin levels, and their relationship with the MetS components was analyzed. Results: In women with MetS components, circulating irisin and betatrophin levels were significantly higher than those in the healthy women, but circulating ZAG and adiponectin levels were significantly lower . FBG, WC, and Triglyceride were significantly correlated with the circulating levels of these four cytokines (p < 0.001 or < 0.05). All four cytokines were associated with MetS and its components. In response to increasing insulin levels, circulating ZAG concentrations were markedly increased in both healthy subjects and women with MetS components during the EHC. However, serum irisin, betatrophin, and adiponectin levels in both healthy subjects and women with MetS components were significantly reduced compared with baseline. Conclusion: Serum ZAG, Irisin, betatrophin and adiponectin were associated with MetS and might be biomarkers for screening MetS components.

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“…ANGPTL8 levels were increased in diabetes [ 14 – 16 ], dyslipidaemia [ 17 , 18 ], CVD [ 19 ], renal function [ 20 – 22 ], obesity [ 23 ], hypertension [ 24 ], and nonalcoholic fatty liver [ 25 ]. Furthermore, studies have revealed that ANGPTL8 levels also increased with age [ 26 , 27 ], suggesting its potential association with aging and with age-related metabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: results from the REACTION Study

Zou

Chen

et al. 2020

Cardiovasc Diabetol

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Background: Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and is associated with insulin resistance. However, the role of ANGPTL8 in the outcomes of diabetic patients remains unclear. This study aimed to investigate circulating levels of ANGPTL8 in participants with and without diabetes and its potential associations with clinical outcomes in a 5 year cohort study. Methods: Propensity-matched cohorts of subjects with and without diabetes from the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A longitudinal (REACTION) study were generated on the basis of age, sex and body mass index at baseline. The primary outcome was all-cause mortality. The secondary outcomes were a composite of new-onset major adverse cardiovascular events, hospitalization for heart failure, and renal dysfunction (eGFR < 60/ min/1.73 m 2). Results: We identified 769 matched pairs of diabetic patients and control subjects. Serum ANGPTL8 levels were elevated in patients with diabetes compared to control subjects (618.82 ± 318.08 vs 581.20 ± 299.54 pg/mL, p = 0.03). Binary logistic regression analysis showed that elevated ANGPTL8 levels were associated with greater risk ratios (RRs) of death (RR in quartile 4 vs. quartile 1, 3.54; 95% CI 1.32-9.50) and renal dysfunction (RR in quartile 4 vs. quartile 1, 12.43; 95% CI 1.48-104.81) only in diabetic patients. Multivariable-adjusted restricted cubic spline analyses revealed a significant, linear relationship between ANGPTL8 and all-cause mortality in diabetic patients (p for nonlinear trend = 0.99, p for linear trend = 0.01) but not in control subjects (p for nonlinear trend = 0.26, p for linear trend = 0.80). According to ROC curve analysis, the inclusion of ANGPTL8 in QFrailty score significantly improved its predictive performance for mortality in patients with diabetes. Conclusion: Serum ANGPTL8 levels were associated with an increased risk of all-cause mortality and could be used as a potential biomarker for the prediction of death in patients with diabetes.

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Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Cited by 13 publications

References 42 publications

A Potential Pathological Role of Wingless Type1 Inducible Signaling Pathway Protein-1 and Betatrophin in Obese Women with Polyststic Ovary Syndrome

A Potential Pathological Role of Wingless Type1 Inducible Signaling Pathway Protein-1 and Betatrophin in Obese Women with Polyststic Ovary Syndrome

Association of metabolic syndrome components with circulating levels of cytokine clusters in young women

Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: results from the REACTION Study

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