Serum concentration of specific IgE antibody against Aspergillus fumigatus and identification of the fungal allergen

Dessaint, J. P.; Bout, Daniel; Fruit, J.; Càpron, André

doi:10.1016/0090-1229(76)90039-8

Cited by 25 publications

(6 citation statements)

References 10 publications

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“…Their absence may have been attributable to the circumstance that most cases would not have been diagnosed until the infection was well established and the main phase of IgM production passed. Antibodies of the IgE class have been detected in allergic bronchopulmonary aspergillosis although they are apparently less frequent in aspergilloma (9,13). Antibodies of the IgA class do not appear to be prominent in the serologicaI response to A. fumigatus either in human infections (17) or, as the present results indicated, in sheep.…”

Section: Discussioncontrasting

confidence: 50%

Examination of the immunoglobulin classes involved in the serological response of pregnant sheep toAspergillus fumigatus

Corbel

Day

1978

Med Mycol

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Pregnant sheep inoculated with Aspergillus fumigatus conidia developed agglutinating and precipitating antibodies for mycelial antigens. The agglutinins were initially exclusively of the IgM class, but were later supplemented by IgG antibodies, although IgM production was usually sustained throughout the serological response. Precipitins active in the immunodiffusion test were of the IgG class. They developed later in the immune response than agglutinins and declined more rapidly. The precipitins and IgG agglutinins were more closely associated with recent active infection than IgM agglutinins.

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Section: Discussioncontrasting

confidence: 50%

Examination of the immunoglobulin classes involved in the serological response of pregnant sheep toAspergillus fumigatus

Corbel

Day

1978

Med Mycol

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“…In contrast, no studies have been pub lished of a search for IgE antibodies, despite the well-documented formation of eryth ematous papulae 30 min after the intradermal injection of soluble P. brasiliensis anti gens [20], Considering that levels of the IgE class appear to be related to depression of CMI in other situations [24], and that a radioimmunoadsorption method has been re cently adapted to the quantitation of specific IgE antibodies against parasitic [5,6,8,10] and fungal [9] antigens, we decided to use this technique to detect specific IgE anti bodies against P. brasiliensis in sera from patients with paracoccidioidomycosis.…”

Section: Introductionmentioning

confidence: 99%

Demonstration and Quantification of IgE Antibodies Against <i>Paracoccidioides brasiliensis</i> in Paracoccidioidomycosis

Yarzábal¹,

Dessaint²,

Arango³

et al. 1980

Int Arch Allergy Immunol

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Using a radioimmunoassay technique, we have determined the total IgE concentration and specific IgE antibody level against Paracoccidioides brasiliensis in the sera of patients with mycologically confirmed active paracoccidioidomycosis. Patients with aspergilloma, or individuals with antibodies against Candida albicans, and sera of apparently healthy individuals from the endemic area were also examined. The level of total IgE was significantly elevated in 9 out of 10 cases of paracoccidioidomycosis. The mean level of specific IgE against P. brasiliensis was significantly higher in the serum of the patients in comparison with control individuals. The percentage of specific IgE relative to the total varied from 0.38 to 2.28%. The differences between IgE levels in paracoccidioidomycosis sera and in the other mycoses were statistically significant. Our results suggest a possible involvement of specific IgE antibodies against P. brasiliensis in the immune response of patients with paracoccidioidomycosis. The hyperimmunoglobulinemia E may be related to the T-cell defect that characterizes the severe forms of the disease.

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“…Some Aspergillus antigens (catalase, trypsine and chymotrypsine) are essential for these reactions. These enzyme activities can be detected after gel diffusion and, as these antigens appear to be specific to AF, may be useful for diagnosis (66). Variation of level of specific antibodies are function of treatment, age and stage of ABPA (67–69).…”

Section: Biologymentioning

confidence: 99%

Allergic bronchopulmonary aspergillosis

Tillie‐Leblond

Tonnel

2005

Allergy

170

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Allergic bronchopulmonary aspergillosis (ABPA) occurs in nonimmunocompromised patients and belongs to the hypersensitivity disorders induced by Aspergillus. Genetic factors and activation of bronchial epithelial cells in asthma or cystic fibrosis are responsible for the development of a CD4+Th2 lymphocyte activation and IgE, IgG and IgA‐AF antibodies production. The diagnosis of ABPA is based on the presence of a combination of clinical, biological and radiological criteria. The severity of the disease is related to corticosteroid‐dependant asthma or/and diffuse bronchiectasis with fibrosis. The treatment is based on oral corticosteroids for 6–8 weeks at acute phase or exacerbation and itraconazole is now recommended and validated at a dose of 200 mg/day for a duration of 16 weeks.

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Serum concentration of specific IgE antibody against Aspergillus fumigatus and identification of the fungal allergen

Cited by 25 publications

References 10 publications

Examination of the immunoglobulin classes involved in the serological response of pregnant sheep toAspergillus fumigatus

Examination of the immunoglobulin classes involved in the serological response of pregnant sheep toAspergillus fumigatus

Demonstration and Quantification of IgE Antibodies Against <i>Paracoccidioides brasiliensis</i> in Paracoccidioidomycosis

Allergic bronchopulmonary aspergillosis

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