Serum Cholesterol Reduction by Chromium in Hypercholesterolemic Rats

Staub, Herbert W.; Reussner, G; Thiessen, R.

doi:10.1126/science.166.3906.746

Cited by 41 publications

(7 citation statements)

References 8 publications

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“…6 -7 Rats fed a hypercholesterolemic diet for 35 days were protected from hypercholesterolemia when supplemented with chromium. 34 The present study documents significantly improved serum cholesterol and total lipids in both diabetic and nondiabetic E subjects receiving the chromium-rich supplement, suggesting a role for chromium in human cholesterol metabolism. It is particularly significant that all individuals who were hypercholesterolemic (>300 mg/dl) showed a fall in their cholesterol levels, and the mean fall was -61 mg/dl.…”

Section: Discussionmentioning

confidence: 81%

Beneficial Effect of Chromium-rich Yeast on Glucose Tolerance and Blood Lipids in Elderly Subjects

1980

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Twenty-four volunteers, mean age 78, including eight mildly non-insulin-dependent diabetics, were randomly allocated to one of two groups and were fed (daily for 8 wk) 9 g of either chromium-rich brewers' yeast (experimental) or chromium-poor torula yeast (control). Before and after yeast supplementation, the serum glucose and insulin response to 100 g oral glucose was measured at 30 min intervals for 2 h. Fasting serum cholesterol, total lipids, and triglycerides were also determined. In the total experimental group (normals + diabetics) and in both the diabetic and nondiabetic experimental subgroups, glucose tolerance improved significantly and insulin output decreased after supplementation. Cholesterol and total lipids fell significantly after supplementation in the total experimental group. The cholesterol decrease was particularly marked in hypercholesterolemic subjects (cholesterol > 300 mg/dl). In the control group, no significant change in glucose tolerance, insulin, triglycerides, or total lipids was found. Cholesterol was significantly lowered in the nondiabetic but not in the diabetic group. Thus, chromium-rich brewers' yeast improved glucose tolerance and total lipids in elderly subjects, while chromium-poor torula yeast did not. An improvement in insulin sensitivity also occurred with brewers' yeast supplementation. This supports the thesis that elderly people may have a low level of chromium and that an effective source for chromium repletion, such as brewers' yeast, may improve their carbohydrate tolerance and total lipids. The improvement in serum cholesterol in some control subjects, as well as in the total experimental group, also suggests the presence of a hypocholesterolemic factor other than chromium in both brewers' and torula yeast.

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Section: Discussionmentioning

confidence: 81%

Beneficial Effect of Chromium-rich Yeast on Glucose Tolerance and Blood Lipids in Elderly Subjects

1980

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“…Similarly, rats fed a hypercholesterolemic diet for 35 days had significantly lower serum cholesterol levels when chromium was added to their drinking water than those who were on the same diet but without additional chromium [14]. Con trolled studies in humans have also shown a decrease in serum cholesterol levels [ 15] and an increase in HDL levels [16].…”

Section: Discussionmentioning

confidence: 84%

Chromium and Cholesterol-Induced Atherosclerosis in Rabbits

Abraham¹,

Brooks

Eylath

1991

Ann Nutr Metab

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Thirty-three rabbits on a cholesterol-enriched diet were randomized into 6 groups and treated with daily injections of either water, 20 µg of potassium chromate or 1, 5, 10 or 20 µg of chromium chloride, respectively, for 135 days with a 2- to 10-fold increase in serum chromium. There was a marked reduction in the percentage of aortic intimal surface covered by plaque, in aortic weight and cholesterol content in the treated animals. Rabbits treated with 20 µg of chromium chloride showed a better response than those treated with either 10 or 20 µg of potassium chromate.

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“…In rats fed a hypercholesterolaemic diet, the addition of chromium has been found to reduce the level of plasma cholesterol with either starch or sucrose as the dietary carbohydrate [13]. Nevertheless, the chromium did not eliminate the difference in the levels of cholesterol produced by the two car bohydrates.…”

Section: Discussionmentioning

confidence: 95%

The Effect of Chromium on the Hyperlipaemic Action of Sucrose

Bruckdorfer

Khan

Yudkin³

1971

Ann Nutr Metab

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(1) Weanling rats of the Sprague-Dawley strain were fed diets with either starch or sucrose as the carbohydrate source, and given either ordinary tap water to drink or tap water containing 5 ppm chromium as the acetate. (2) Weight gains were somewhat less with sucrose than with starch, and not affected by the addition of chromium. (3) In the liver, sucrose compared with starch increased the weight, the total amount of lipid, and the concentration of phospholipid, total cholesterol and esterified cholesterol. In the plasma, it increased the concentration of phospholipid, free cholesterol and particularly triglyceride. These effects of sucrose confirm previous work from this department. (4) In the livers of starch-fed rats, the addition of chromium reduced the level of triglyceride and increased the level of phospholipid. In the sucrose-fed rats, it increased the level of esterified cholesterol. (5) In the plasma, the addition of chromium increased the level of phospholipid in the starch-fed rats, and increased the level of free cholesterol in the surcrose-fed rats. As a result of this last effect, there was no longer a difference in free cholesterol levels between starch-fed and sucrose-fed rats. (6) The changes described do not support the suggestion that the effects of dietary sucrose in producing changes in lipid concentration in the liver and plasma are due to a deficiency of chromium in such diets.

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Serum Cholesterol Reduction by Chromium in Hypercholesterolemic Rats

Cited by 41 publications

References 8 publications

Beneficial Effect of Chromium-rich Yeast on Glucose Tolerance and Blood Lipids in Elderly Subjects

Beneficial Effect of Chromium-rich Yeast on Glucose Tolerance and Blood Lipids in Elderly Subjects

Chromium and Cholesterol-Induced Atherosclerosis in Rabbits

The Effect of Chromium on the Hyperlipaemic Action of Sucrose

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