Serum Cholesterol Binding Reserve and High Density Lipoprotein Cholesterol in Patients on Maintenance Hemodialysis

Abstract

Serum cholesterol binding reserve (SCBR, the capacity of the serum to solubilize additional cholesterol), high density lipoprotein cholesterol (HDL . Ch) and serum levels of cholesterol and triglycerides were measured in 53 chronically uremic patients (40 men and 13 women) undergoing maintenance hemodialysis. The values were compared with those of controls (149 men and 28 women) matched for serum lipid levels. Hypertriglyceridemia and decreased HDL . Ch were observed among the patients, confirming previous reports. SCBR values of the patients were not significantly different from those of controls except in a small subgroup of uremic diabeties, whose SCBR values were markedly decreased. There was a positive correlation between SCBR and the duration for which the patients had been maintained by hemodialysis. The results suggest that patients with higher SCBR values have a better prospect for surviving long duration of hemodialysis.

Comparison of Several Atherogenicity Indices by the Analysis of Serum Lipoprotein Composition in Patients with Chronic Renal Failure with or without Haemodialysis, and in Renal Transplant Patients

“…The present study confirms previously well-known lipid anomalies in ufaemic patients treated or untreated by intermittent haemodialysis, i. e., hypertriglyceridaemia, a decrease of serum HDL-cholesterol and an increase of the so-called cardiovascular risk factors (13,15,16,(18)(19)(20)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). In addition, we have demonstrated that lipid anomalies were more marked in uraemic patients with more advanced renal failure than in those with moderate renal insufficiency.…”

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

“…These data indicate that during statin treatment it is mainly the cholesterol-dependent lipoprotein binding capacity in the circulation that will determine the 4β-OH-cholesterol concentration in plasma, rather than a direct effect on the hepatic CYP3A4 enzyme. A disturbed cholesterol-dependent lipoprotein binding capacity in HD patients may also be operative [ 46 ]. Taken together, our results suggest that the ratio 4β-OH-cholesterol/cholesterol rather than 4β-OH-cholesterol alone, is the preferred measure of CYP3A4 activity.…”

Study of serum cholesterol binding reserve in case of coronary artery diseases with special emphasis on acute coronary syndrome

“…The lower the SCBR the higher the tendency to develop atherosclerosis and hence the higher the risk of coronary heart disease. 6 Reverse cholesterol transport prevent deposition of cholesterol in tissue and thought to be antiartherogenic and HDL cholesterol level has been shown to low risk of coronary heart disease. 3 Acute myocardial infarction (AMI) and unstable angina are now recognized as part of a spectrum of clinical disease collectively known as acute coronary syndromes (ACS).…”