Serum Caspase-1 levels in women with polycystic ovary syndrome

Çabuş, Ümit; Kabukçu, Cihan; Fenkci, Semin; Caner, Vildan; Öztekin, Özer; Fenkçi, Veysel; Enli, Yaşar

doi:10.1016/j.tjog.2020.01.007

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…21 According to Umit Cabus' study, serum IL-10 levels were greater in study participants than in controls, and the LH/FSH ratio was noticeably higher in PCOS-affected women. 22 When compared to controls, PCOS patients' mean plasma concentration of IL10 was significantly lower, and it had no effect on the levels of FSH, LH, or PRL. 23 Hyperinsulinemia stimulates the pituitary's reaction to gonadotropin-releasing hormone (GnRH), which increases the release of luteinizing hormone and androgen.…”

Section: Discussionmentioning

confidence: 86%

Association between hormonal Imbalance and Interleulin-10 level with Polycystic Ovarian Syndrome of Iraqi women

Al-Quraishy

Ali

Al-Tu’ma

et al. 2022

J. Contemp. Med. Sci.

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Objectives: To determine the level of interleukin-10 as inflammatory marker in PCOS patients and compared with healthy control and explore the correlation between IL-10 level and other biochemical markers in PCOS patients. Methods: Whole blood samples of 80 PCOS obese patients and 80 healthy people were collected in duration from Dec., 2021 to April, 2022, at the gynecological and obstetric teaching hospital, Kerbala health directorate, Iraq. The Rotterdam criteria-2003 was accepted to PCOS females with age range between (18-40 years), while the apparently control group with age ranged between (18-40 years). BMI and WHR and hormonal status (LH, FSH, LH/FSH ratio, Prolactin, Free Testosterone) were determined. Elabscience/USA ELISA kit uses the Sandwich-ELISA principle was used to determined IL-10 level in serum. Results: The obese PCOS women had a seriously decrease in IL-10 (pg/ml) level when compare with apparently healthy control group with mean ± SD for patients (2.192 ± 0.47) and for control group (4.532 ± 0.75) P value < 0.0001, and there are significant negative correlations between IL-10 and (BMI p<0.0001, r= -0.66), (WHR p<0.0001, r= -0.66), (LH p<0.0001, r= -0.63), (LH: FSH ratio p<0.0001, r= -0.72), (Prolactin p=0.008, r= -029). Conclusion: Our findings indicate that the IL-10 level decrease in PCOS obese patients and has significant association with pathogenesis and progression of disease.

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Section: Discussionmentioning

confidence: 86%

Association between hormonal Imbalance and Interleulin-10 level with Polycystic Ovarian Syndrome of Iraqi women

Al-Quraishy

Ali

Al-Tu’ma

et al. 2022

J. Contemp. Med. Sci.

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“…4 Among these, polycystic ovary syndrome may be one of best examples. [5][6][7] In their study, this hypothesis seems to be supported by their study, since according to the significant increase of LDL-C and decrease HDL-C in transmen treated with androgen, the authors concluded this androgen-related change of lipid profile may increase the CVD risk in transmen. 1 We do not want to argue this conclusion.…”

mentioning

confidence: 73%

Trans sexualism

Lee

Chang

Wang

2021

Journal of the Chinese Medical Association

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“…Tshori et al [161], Cheng et al [162], Nowzari et al [163], Choi et al [164], Ji et al [165], Huang et al [166], Zhai et al [167], Schiattarella et al [168], Brodehl et al [169], Wu et al [170], Zhao et al [171], Ujihara et al [172], Tan et al [173], Gittleman et al [174], Chen et al [175], Layrisse et al [176], Nakayama et al [177], Zhang et al [178], Vadvalkar et al [179], Burdon et al [180], Steffen et al [181], Ye et al [182], Tao et al [183] and Li et al [184] reported that PLA2G5, CASP1, TNNT2, FOXP3, DRD4, NEURL1, TIMP4, SOCS1, CD74, PLK1, ATF5, GATA6, IRF7, FOXC2, IRF9, FHOD3, BGN (biglycan), CACNA1H, FBLN2, ADAMTS8, COL1A1, POSTN (periostin), VARS2, SOD3, ADAMTS13, FABP5, ADAM23, COL1A2, MST1, ENDOG (endonuclease G), NKX2-6, MYOCD (myocardin), CES1, CYP19A1, PKP2, CD36, SALL1, ARG1, MSR1, S1PR1, OXTR (oxytocin receptor), MITF (melanocyte inducing transcription factor), MSX2, LEPR (leptin receptor), CDH13, PRKCH (protein kinase C eta), AR (androgen receptor), DKK3, FOXO1, CRYAB (crystallin alpha B), B2M, WWP1, FKTN (fukutin), PIK3C2A, KLKB1, CHRNA5, HLA-C, ARRDC4, KCNE3, MPC2, EPHX2, C2, IKZF2, ZBTB20 and RCN2 expressions might be regarded as an indicator of susceptibility to cardiovascular problems. CASP1 [185], FOXP3 [186], SOCS1 [187], GATA6 [188], IRF7 [189], POSTN (periostin) [190], CYP19A1 [191], CD36 [192], LYN (LYN proto-oncogene, Src family tyrosine kinase) [193], CD4 [194], LEPR (leptin receptor) [195], AR (androgen receptor) [196], FOXO1 [197] and PON2 [198] are a potential biomarkers for the detection and prognosis of PCOS. Udjus et al [199] Benjafield et al [200], Shetty et al [58], Kassan et al [201], Wetzl et al [202], Le Hiress et al [203], Pal-Ghosh et al [204], Niu, [205], Fan et al [206], Deng et al [207], Chen et al [208], Sardo et al [209], Seidel et al [210], Zhu et al [211], Omura et al [212], Hu et al [213], Castoldi et al [214], Yoshida et al [215], Palao et al [216…”

Section: Discussionmentioning

confidence: 99%

The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics Analysis

Vastrad¹,

Vastrad²

2023

Preprint

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Polycystic ovary syndrome (PCOS) is is associated with infertility, obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, hypertension, cardiovascular problems, neurological and psychological problems and cancer. The specific mechanism of PCOS and its complications remains unclear. The aim of this study was to apply a bioinformatics approach to reveal related pathways or genes involved in the development of PCOS and its complications. The next generation squancing (NGS) datset GSE199225 was downloaded from the gene expression omnibus (GEO) database. Differentially expressed gene (DEG) analysis was performed using DESeq2. The g:Profiler was utilized to analyze the functional enrichment, gene ontology (GO) and REACTOME pathway of the differentially expressed genes. A protein-protein interaction (PPI) network was constructed and module analysis was performed using HiPPIE and cytoscape. The miRNA-hub gene regulatory network and TF-hub gene regulatory network were also constructed for research. The expression of the hub genes was validated using receiver operating characteristic (ROC) curve analysis. We have identified 957 DEGs in total, including 478 up regulated genes and 479 down regulated gene. GO and REACTOME illustrated that DEGs in PCOS were significantly enriched in regulation of molecular function, developmental process, interferon signaling and platelet activation, signaling and aggregation. Finally, through analyzing the PPI network, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network, we screened hub genes HSPA5, PLK1, RIN3, DBN1, CCDC85B, DISC1, AR, MTUS2, LYN and TCF4 by the Cytoscape software. This study uses a series of bioinformatics technologies to obtain hug genes and key pathways related to PCOS and its complications. These analysis results provide us with novel ideas for finding biomarkers and treatment methods for PCOS and its complications.

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Serum Caspase-1 levels in women with polycystic ovary syndrome

Cited by 7 publications

References 25 publications

Association between hormonal Imbalance and Interleulin-10 level with Polycystic Ovarian Syndrome of Iraqi women

Association between hormonal Imbalance and Interleulin-10 level with Polycystic Ovarian Syndrome of Iraqi women

Trans sexualism

The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics Analysis

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